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Zetasizer - Malvern Panalytical Advance Series Ultra


Contact: Dmitry Koktysh
ESB 107 - Analytical

Fee Structure

Get Access - Vanderbilt
Get Access - Non-Vanderbilt

Zetasizer Ultra provides the ability to measure particle and molecule size, particle charge, molecular weight and particle concentration in a liquid medium using light scattering and laser doppler electrophoresis.

Key Features

  • Multi-Angle Dynamic Light Scattering (MADLS) for absolute confidence in particle and molecular size distribution analysis
  • Dynamic Light Scattering (DLS) measures particle and molecule size, from 0.3 nm to 10 µm
  • Electrophoretic Light Scattering (ELS) measures the zeta potential of particles and molecules, indicating sample stability and/or propensity to aggregate
  • Non-Invasive Back Scatter (NIBS) optics for versatile, high sensitivity, particle and molecular size measurements
  • Simple, per-peak concentration / titer measurements
  • Disposable capillary sizing cell provides the ultimate in non-destructive, low volume (down to 3 µL) analysis, with an upper size range that extends to 10 ?m
  • M3-PALS with Constant Current Mode for zeta potential and electrophoretic mobility measurements
  • ZS Xplorer software suite for simple and flexible method set-up and data analysis
  • Adaptive Correlation for faster, more reproducible sizing measurements with less sample preparation
  • Deep Learning empowered data quality system for assessment of any size data quality issues, with clear advice on how to improve results
  • Optical filter wheel with fluorescence filter to allow measurement of fluorescent samples without impairing overall system sensitivity. Also includes polarization filters for DDLS measurements


  • Measurement types: particle/molecular size, absolute molecular weight, zeta potential
  • Measurement types: particle/molecular size, particle concentration, absolute molecular weight, zeta potential
  • Size measurement from 0.3 nm (diameter) to 10 microns using patented NIBS (Non-Invasive Back Scatter) Dynamic Light Scattering, Dynamic Light Scattering (90° and 13°), Multi-Angle Dynamic Light Scattering (MADLS)
  • Zeta potential using patented M3-PALS technology and Constant Current Mode
  • Molecular weight measurement using Static Light Scattering (90° and 173°)
  • Protein size measurement as dilute as 0.1 mg/mL 15kDa Protein
  • Sample concentrations from 0.1 ppm to 40% w/v
  • Temperature range extension option to 120 °C 
  • Incorporates polarization, fluorescence optical filters
  • He-Ne laser 633 nm, Max 10 mW
  • Measurement type: Particle size and molecular size
  • Measurement range 0.3nm – 10.0 microns (diameter)
  • Measurement principle: Dynamic Light Scattering (NIBS and MADLS)
  • Minimum sample volume: 3µL
  • Measurement type: Zeta potential (and optional Protein Mobility)
  • Measurement principle: Mixed-Mode Measurement phase analysis light scattering (M3-PALS)
  • Measurement range: 3.8nm – 100 microns (diameter)
  • Minimum sample volume: 20µL
  • Concentration range: 1 mg/mL to 40% w/v
  • Sensitivity: 10mg/mL (BSA)
  • Measurement type: Molecular weight
  • Measurement range: 980Da – 20M Da
  • Measurement principle: Static Light Scattering using Debye plot
  • Accuracy: +/- 10% typical
  • Measurement type: Particle concentration
  • Measurement principle: MADLS – Particle concentration (Mie)
  • Concentration range: 1x108 to1x1012 particles/mL

Zetasizer Ultra Resources

Malvern Panalytical Zetasizer Ultra