Zetasizer - Malvern Panalytical Advance Series Ultra
Overview
Contact: Dmitry Koktysh
ESB 107 - Analytical
615-343-6757
Fee Structure
Get Access - Vanderbilt
Get Access - Non-Vanderbilt
Zetasizer Ultra provides the ability to measure particle and molecule size, particle charge, molecular weight and particle concentration in a liquid medium using light scattering and laser doppler electrophoresis.
Key Features
- Multi-Angle Dynamic Light Scattering (MADLS) for absolute confidence in particle and molecular size distribution analysis
- Dynamic Light Scattering (DLS) measures particle and molecule size, from 0.3 nm to 10 µm
- Electrophoretic Light Scattering (ELS) measures the zeta potential of particles and molecules, indicating sample stability and/or propensity to aggregate
- Non-Invasive Back Scatter (NIBS) optics for versatile, high sensitivity, particle and molecular size measurements
- Simple, per-peak concentration / titer measurements
- Disposable capillary sizing cell provides the ultimate in non-destructive, low volume (down to 3 µL) analysis, with an upper size range that extends to 10 ?m
- M3-PALS with Constant Current Mode for zeta potential and electrophoretic mobility measurements
- ZS Xplorer software suite for simple and flexible method set-up and data analysis
- Adaptive Correlation for faster, more reproducible sizing measurements with less sample preparation
- Deep Learning empowered data quality system for assessment of any size data quality issues, with clear advice on how to improve results
- Optical filter wheel with fluorescence filter to allow measurement of fluorescent samples without impairing overall system sensitivity. Also includes polarization filters for DDLS measurements
Capabilities
- Measurement types: particle/molecular size, absolute molecular weight, zeta potential
- Measurement types: particle/molecular size, particle concentration, absolute molecular weight, zeta potential
- Size measurement from 0.3 nm (diameter) to 10 microns using patented NIBS (Non-Invasive Back Scatter) Dynamic Light Scattering, Dynamic Light Scattering (90° and 13°), Multi-Angle Dynamic Light Scattering (MADLS)
- Zeta potential using patented M3-PALS technology and Constant Current Mode
- Molecular weight measurement using Static Light Scattering (90° and 173°)
- Protein size measurement as dilute as 0.1 mg/mL 15kDa Protein
- Sample concentrations from 0.1 ppm to 40% w/v
- Temperature range extension option to 120 °C
- Incorporates polarization, fluorescence optical filters
- He-Ne laser 633 nm, Max 10 mW
- Measurement type: Particle size and molecular size
- Measurement range 0.3nm – 10.0 microns (diameter)
- Measurement principle: Dynamic Light Scattering (NIBS and MADLS)
- Minimum sample volume: 3µL
- Measurement type: Zeta potential (and optional Protein Mobility)
- Measurement principle: Mixed-Mode Measurement phase analysis light scattering (M3-PALS)
- Measurement range: 3.8nm – 100 microns (diameter)
- Minimum sample volume: 20µL
- Concentration range: 1 mg/mL to 40% w/v
- Sensitivity: 10mg/mL (BSA)
- Measurement type: Molecular weight
- Measurement range: 980Da – 20M Da
- Measurement principle: Static Light Scattering using Debye plot
- Accuracy: +/- 10% typical
- Measurement type: Particle concentration
- Measurement principle: MADLS – Particle concentration (Mie)
- Concentration range: 1x108 to1x1012 particles/mL