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Todd D. Giorgio

Professor of Biomedical Engineering
Professor of Chemical and Biomolecular Engineering
Professor of Cancer Biology

Research:

Research in the Giorgio laboratory is motivated by the quantitative understanding of complex living systems at increasingly refined spatial and temporal scales. The primary focus of this activity has been in addressing critical problems in understanding and treating cancer. Our laboratory applies novel engineering and science approaches to the study of metastases, recurrence and immunity. We have developed a number of new nanoscale materials with biosensing surfaces, including ‘smart’ micelles that deliver functional siRNA to macrophages or use switchable surface charge for tissue localization, retention and controlled release of siRNA. The objective has been to harness the enormous power of cancer immunomodulation, avoiding the systemic responses that otherwise limit such approaches. These immunomodulatory nanomaterials have been designed for local or systemic administration and have demonstrated effectiveness in vivo. Overall, our laboratory combines cancer biology and immunology expertise with quantitative engineering approaches for the design, development and assessment of novel biomaterials for use in living systems.

Awards:

AIMBE Board of Directors, 2014
Chair, AIMBE Academic Council, 2014
Chair, Council of Biomedical Engineering Department Chairs, 2012
Fellow, Biomedical Engineering Society, 2011
Chair, ASGCT Chemical Gene and Cell Therapy Committee, 2009
Fellow, American Institute for Medical and Biological Engineering (AIMBE), 2007
Professional Engineer, registration number 021993, State of Tennessee, 1990
Sigma Xi, 1990
Engineer-in-Training, Commonwealth of Pennsylvania, 1982
Tau Beta Pi, 1982

Selected Publications:

Macrophage-Specific RNA Interference Targeting via "Click", Mannosylated Polymeric Micelles. Yu, SS; Lau, CM; Barham, WJ; Onishko, HM; Nelson, CE; Li, HM; Smith, CA; Yull, FE; Duvall, CL; Giorgio, TD, MOLECULAR PHARMACEUTICS, 10, 975-987 , (2013) View Abstract

Size- and charge-dependent non-specific uptake of PEGylated nanoparticles by macrophages. Yu, SS; Lau, CM; Thomas, SN; Jerome, WG; Maron, DJ; Dickerson, JH; Hubbell, JA; Giorgio, TD, INTERNATIONAL JOURNAL OF NANOMEDICINE, 7, 799-813 , (2012) View Abstract

The Multistrata Nanoparticle: an FeOx/Au Core/Shell Enveloped in a Silica–Au Shell . Bell, CS, Yu, SS, Giorgio, TD, SMALL, 7, 1158-1162 , (2011)