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Todd D. Giorgio

Professor of Biomedical Engineering
Professor of Chemical and Biomolecular Engineering

Research:

Research in the Giorgio laboratory is motivated by the quantitative understanding of complex living systems at increasingly refined spatial and temporal scales. The primary focus of this activity has been in addressing critical problems in understanding and treating cancer. Our laboratory applies novel engineering and science approaches to the study of metastases, recurrence and immunity. We have developed a number of new nanoscale materials with biosensing surfaces, including ‘smart’ micelles that deliver functional siRNA to macrophages or use switchable surface charge for tissue localization, retention and controlled release of siRNA. The objective has been to harness the enormous power of cancer immunomodulation, avoiding the systemic responses that otherwise limit such approaches. These immunomodulatory nanomaterials have been designed for local or systemic administration and have demonstrated effectiveness in vivo. Overall, our laboratory combines cancer biology and immunology expertise with quantitative engineering approaches for the design, development and assessment of novel biomaterials for use in living systems.

Awards:

• Chair, BMES Public Relations Committee (three-year term), 2016
• Member, BMES Board of Directors (three-year term), 2015
• AIMBE Board of Directors, 2014
• Chair, AIMBE Academic Council, 2014
• Chair, Council of Biomedical Engineering Department Chairs, 2012
• Fellow, Biomedical Engineering Society, 2011
• Chair, ASGCT Chemical Gene and Cell Therapy Committee, 2009
• Fellow, American Institute for Medical and Biological Engineering (AIMBE), 2007
• Professional Engineer, registration number 021993, State of Tennessee, 1990
• Sigma Xi, 1990
• Engineer-in-Training, Commonwealth of Pennsylvania, 1982
• Tau Beta Pi, 1982

Selected Publications:

Synthesis of Iron Nanoparticles for Enhanced MRI Contrast Agents. King, JE: Hah, HY; Johnson, CE; Johnson, JA; Pawel, MD; Rondinone, AJ; Kirkbride, KC; Giorgio, TD, JOURNAL OF NANOSCIENCE WITH ADVANCED TECHNOLOGY, 2, 14-19 , (2018) View Abstract

Magnetic Extraction of Acinetobacter baumannii Using ColistinFunctionalized gamma-Fe2O3/Au Core/Shell Composite Nanoclusters. Bell, CS; Mejias, R; Miller, SE; Greer, JM; McClain, MS; Cover, TL; Giorgio, TD, ACS APPLIED MATERIALS & INTERFACES, 9, 26719-26730 , (2017) View Abstract

Optimization of Micromagnetic Separation for Bacteremia Treatment. Petty Velenzuela, SN; Miller, SE; Bell, CS; Giorgio, TD, JOURNAL OF THEORETICAL AND APPLIED NANOTECHNOLOGY, 5, 27-35 , (2017) View Abstract

Sensing trace levels of molecular species in solution via zinc oxide nanoprobe Raman spectroscopy. Cook, AL; Carson, CS; Marvinney, CE; Giorgio, TD; Mu, RR, JOURNAL OF RAMAN SPECTROSCOPY, 48, 1116-1121 , (2017) View Abstract

Manipulating the NF-kB Pathway in Macrophages Using Mannosylated, siRNA Delivering Nanoparticles Can Induce Immunostimulatory and Tumor Cytotoxic Functions. Ortega, RA; Barham, W; Sharman, K; Tikhomirov, O; Giorgio, TD; Yull FE, INTERNATIONAL JOURNAL OF NANOMEDICINE, 11, 2163-77 , (2016) View Abstract