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Craig L. Duvall

Cornelius Vanderbilt Chair
Professor of Biomedical Engineering

Research:

The Duvall Advanced Therapeutics Laboratory (ATL) specializes in design and application of smart polymer-based technologies for: (1) intracellular delivery of biological drugs such as peptides and nucleic acids, (2) proximity-activated targeting of drugs to sites of inflammation and matrix remodeling, and (3) long-term, “on-demand” drug release from localized depots. These delivery systems are designed to improve the therapeutic benefit and safety of existing drugs and/or to serve as enabling technologies for manipulation of intracellular targets currently considered to be “undruggable”. To achieve optimal, finely-tuned properties for these varied biomedical applications, we develop polymers that respond to one or more environmental stimuli including pH, matrix metalloproteinases, reactive oxygen species, and temperature. The disease applications of our polymeric biomaterial and drug delivery technologies are broad, including increasing longevity and function of transplanted vascular grafts and cell-based therapies, promoting healing of chronic skin wounds, and developing improved breast cancer drugs.

Awards:

• Fellow of American Institute for Medical and Biological Engineering (AIMBE), 2018
• Vanderbilt Chancellor’s Faculty Fellow, 2018
• Presidential Early Career Award for Scientists and Engineers (PECASE), 2017
• China-America Frontiers of Engineering NAE Symposium Participant, 2017
• Biomedical Engineering Society (BMES) CMBE Young Innovator Award, 2016
• Society for Biomaterials Young Investigator Award, 2015
• NSF CAREER Award, 2014

Selected Publications:

Lipophilic siRNA targets albumin in situ and promotes bioavailability, tumor penetration, and carrier-free gene silencing. Sarett, SM; Werfel, TA; Lee, L; Jackson, MA; Kilchrist, KV; Brantley-Sieders, D; Duvall, CL, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 114, E6490-E6497 , (2017) View Abstract

Porous Silicon and Polymer Nanocomposites for Delivery of Peptide Nucleic Acids as Anti-MicroRNA Therapies. Beavers, Kelsey R.; Werfel, Thomas A.; Shen, Tianwei; Kavanaugh, Taylor E.; Kilchrist, Kameron V.; Mares, Jeremy, W.; Fain, Joshua S.; Wiese, Carrie B.; Vickers, Kasey C.; Weiss, Sharon M.; Duvall, Craig L., Advanced Materials, , , (2016) View Abstract

MK2 inhibitory peptide delivered in nanopolyplexes prevents vascular graft intimal hyperplasia. Evans, BC; Hocking, KM; Osgood, MJ; Voskresensky, I; Dmowska, J; Kilchrist, KV; Brophy, CM; Duvall, CL, SCIENCE TRANSLATIONAL MEDICINE, 7, 291ra95 , (2015) View Abstract

Cell Protective, ABC Triblock Polymer-Based Thermoresponsive Hydrogels with ROS-Triggered Degradation and Drug Release. Gupta, MK; Martin, JR; Werfel, TA; Shen, TW; Page, JM; Duvall, CL, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 136, 14896-14902 , (2014) View Abstract

Tunable Delivery of siRNA from a Biodegradable Scaffold to Promote Angiogenesis In Vivo. Nelson, CE; Kim, AJ; Adolph, EJ; Gupta, MK; Yu, F; Hocking, KM; Davidson, JM; Guelcher, SA; Duvall, CL, ADVANCED MATERIALS, 26, 607-614 , (2014)