Karen Davis
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CSB Cryo-EM Directors receive Research Excellence Award
Left to right: Daniel Diermeier, Melissa Chambers, Scott Collier and Candice Storey Lee (Harrison McClary/Vanderbilt) Melissa Chambers and Scott Collier were recently recognized with the Research Excellence Award at the 2023 Fall Staff Assembly. The Cryo-EM co-directors were honored for their research support, which has made a significant impact… Read MoreSeptember 29, 2023
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A glimpse into higher-order mRNP assemblies
In eukaryotic cells, mRNA is transcribed in the nucleus. Protein factors rapidly bind to newly transcribed mRNA to form a messenger ribonucleoprotein (mRNP), which is exported to the cytoplasm for translation. One complex in humans vital for the formation and export of mRNPs is the transcription-export complex (TREX). TREX… Read MoreSeptember 29, 2023
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2024 Karpay Award: Call for applications
The Karpay Award Committee is now soliciting applications for the 2024 Karpay Award in Structural Biology. This award was established in 2010 to commemorate Dr. Anne Karpay, whose studies were focused on membrane protein structural biology under the guidance of Professors Chuck Sanders and Tina Iverson. Dr. Karpay’s… Read MoreSeptember 20, 2023
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On the origins of pentose sugars in everninomicin D biosynthesis
Everninomicins are a family of naturally produced oligosaccharides, some of which exhibit ribosome-targeting antibiotic activity. Everninomicin A (EVA) was developed into late-phase clinical trials as an antibiotic but eventually pulled due to toxicity concerns. Toxicity was attributed to aggregates in the formulations, likely caused by π-stacking interactions from flanking aromatic… Read MoreSeptember 20, 2023
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CSB researchers receive funding for novel research
The American Society for Cell Biology (ASCB) recently announced the formation of Peer Imaging Clusters (PIC) to receive collaborative research grants to pursue novel research projects as part of the PAIR-UP Imaging Science program for Black imaging scientists. Jamaine Davis, PhD Meharry Medical College… Read MoreSeptember 20, 2023
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MOE training sessions set for August, September & October
Molecular Operating Environment (MOE) software users can participate in training sessions for small molecule virtual screening, fragment-based drug design and peptide modeling, conformational searching and docking over the next three months. Mauricio Rodriguez, of Chemical Computing Group, will lead the training sessions via Zoom. MOE enables… Read MoreAugust 11, 2023
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Clicking into place with paramagnetic NMR restraints
Kaitlyn Ledwitch, Assistant Research ProfessorJens Meiler, Distinguished Research Professor Nuclear magnetic resonance (NMR) is an incredibly powerful technique for determining protein structure. A complete dataset of chemical shifts (CS) and nuclear Overhauser effects (NOEs) obtained from NMR can be used to determine structural models of a protein of interest. Read MoreJuly 14, 2023
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CSB Spotlight: Yang Lab
John Yang, assistant professor of chemistry, joined the Vanderbilt University in the fall of 2020. He forged his path to Vanderbilt via Nankai University in China, UCLA and MIT with research focusing on theoretical and computational chemistry, chemical biology, physical organic chemistry and enzyme catalysis. John… Read MoreJuly 6, 2023
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Jackson named 2023 Chancellor Faculty Fellow
Lauren Jackson, PhDBiological Sciences Congratulations to Lauren Jackson, associate professor of biological sciences, on being selected to the 2023 cohort of Chancellor Faculty Fellows along with twelve other recently tenured faculty. The fellows are composed of highly accomplished teachers and researchers from a wide variety of disciplines and… Read MoreJune 12, 2023
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Structural plasticity in bacterial flagellar motors
Chemotaxis is the process of moving in response to one’s environment, and in bacteria, this process is supported largely by flagella. The flagellum is a motility organelle comprised of an elongated filament and various rings, consistent with its role as a rotary motor. One component, the MS-ring, is vital, both… Read MoreJune 12, 2023