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Karen Davis

  • Vanderbilt University

    VUStruct aims to make personalized structural biology faster with its automated pipeline for variants of unknown significance (VUS)

    The use of computational tools to provide a clinical diagnosis of genetic variants of unknown significance (VUSs) of rare diseases, in which the diagnosis is mainly informed by gene-phenotype association databases and DNA scoring methods, has been limited. Tools such as GERP, SIFT, and Polyphen have been shown to differentiate… Read More

    Jun. 25, 2026

  • Vanderbilt University

    Marked for destruction: designing new targets for protein degradation therapies

    Alex Waterson, PhD, Research Professor, Pharmacology and ChemistryFesik Lab Targeted protein degradation (TPD) represents an emerging class of therapeutics that selectively degrades disease-relevant proteins. For example, targeted degradation of oncoproteins in a tumor can inhibit tumor growth while minimizing the toxic side effects of traditional chemotherapy. The degradation relies… Read More

    Jun. 5, 2026

  • Vanderbilt University

    Egli presented recent Kairos Lecture

    Martin Egli, the Richard N. Armstrong, Ph.D. Professor of Innovation in Biochemistry and a professor of biochemistry, delivered the Kairos Lecture on May 28. His scientific accomplishments have resulted in over 300 publications and two influential nucleic acid textbooks, and he has received major honors and extensively served… Read More

    Jun. 4, 2026

  • Vanderbilt University

    Eichman awarded prestigious Royal Society Wolfson Visiting Fellowship

    Brandt Eichman, PhD Congratulations to William R. Kenan, Jr. Chair, Professor of Biological Sciences and CSB researcher Brandt Eichman on being the first Vanderbilt faculty member to be awarded the prestigious Royal Society Wolfson Visiting Fellowship. The fellowship, jointly funded by the the… Read More

    May. 22, 2026

  • Isomerization insights: a deeper understanding of Pin1-PPARγ dynamics

    Isomerization insights: a deeper understanding of Pin1-PPARγ dynamics

    Amino acid peptides can exist in cis and trans conformations, with most heavily favoring the latter. Proline, however, is unique among amino acids in that its peptide bonds can stably populate both conformations. The exchange, or isomerization, between cis and trans proline conformations is a relatively slow process which… Read More

    Jul. 11, 2025

  • CSB Spotlight: Rachana Tomar, Stone Lab

    CSB Spotlight: Rachana Tomar, Stone Lab

    Rachana Tomar, Research Assistant, Stone Lab Rachana Tomar is a research assistant in the Stone lab. She spends her days unraveling the mysteries of aflatoxin B1 (AFB1) and its knack for causing mutations that can lead to cancer. When she clocks out, Rachana trades her lab coat… Read More

    Jun. 26, 2025

  • External speakers set for CSB/CAIPD symposium

    External speakers set for CSB/CAIPD symposium

    The Vanderbilt Center for Structural Biology and the Center for Applied AI in Protein Dynamics invite you to Bridging Atoms and Algorithms: A Symposium on AI and Structural Biology. The symposium promises exciting research, collaboration and networking that navigates the intersection of AI and Structural… Read More

    Jun. 17, 2025

  • CSHL macromolecular crystallography course

    CSHL macromolecular crystallography course

    Cold Spring Harbor Laboratory (CSHL) is a leading international center for research and education. As part of its mission, each year CSHL organizes 30 advanced technical science courses, with organizers, instructors and participants from all over the world. CSHL is offering a course in macromolecular crystallography October… Read More

    Jun. 10, 2025

  • Call for Nominations: 2025 Vanderbilt Prize Student Scholar

    Call for Nominations: 2025 Vanderbilt Prize Student Scholar

    Nominations for the 2025 Vanderbilt Prize Student Scholar are invited now through June 27, 2025. Candidates for the Vanderbilt Prize Student Scholar are graduate students in biomedical sciences at Vanderbilt (Ph.D. or M.D./Ph.D. track) who have completed the qualifying exam and have at least one year… Read More

    Jun. 10, 2025

  • CSB Spotlight: Prashant Singh, Iverson Lab

    CSB Spotlight: Prashant Singh, Iverson Lab

    Prashant Singh, Senior Research Associate, Iverson Lab Prashant Singh, is a Senior Research Associate in the Iverson Lab. He’s getting used to the spotlight from his recent appearance on the YouTube channel SmarterEveryDay. However, he’s still the down-to-earth Prash, as he’s known… Read More

    May. 30, 2025