Karen Davis
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Isomerization insights: a deeper understanding of Pin1-PPARγ dynamics
Amino acid peptides can exist in cis and trans conformations, with most heavily favoring the latter. Proline, however, is unique among amino acids in that its peptide bonds can stably populate both conformations. The exchange, or isomerization, between cis and trans proline conformations is a relatively slow process which… Read MoreJuly 11, 2025
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CSB Spotlight: Rachana Tomar, Stone Lab
Rachana Tomar, Research Assistant, Stone Lab Rachana Tomar is a research assistant in the Stone lab. She spends her days unraveling the mysteries of aflatoxin B1 (AFB1) and its knack for causing mutations that can lead to cancer. When she clocks out, Rachana trades her lab coat… Read MoreJune 26, 2025
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External speakers set for CSB/CAIPD symposium
The Vanderbilt Center for Structural Biology and the Center for Applied AI in Protein Dynamics invite you to Bridging Atoms and Algorithms: A Symposium on AI and Structural Biology. The symposium promises exciting research, collaboration and networking that navigates the intersection of AI and Structural… Read MoreJune 17, 2025
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CSHL macromolecular crystallography course
Cold Spring Harbor Laboratory (CSHL) is a leading international center for research and education. As part of its mission, each year CSHL organizes 30 advanced technical science courses, with organizers, instructors and participants from all over the world. CSHL is offering a course in macromolecular crystallography October… Read MoreJune 10, 2025
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Call for Nominations: 2025 Vanderbilt Prize Student Scholar
Nominations for the 2025 Vanderbilt Prize Student Scholar are invited now through June 27, 2025. Candidates for the Vanderbilt Prize Student Scholar are graduate students in biomedical sciences at Vanderbilt (Ph.D. or M.D./Ph.D. track) who have completed the qualifying exam and have at least one year… Read MoreJune 10, 2025
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CSB Spotlight: Prashant Singh, Iverson Lab
Prashant Singh, Senior Research Associate, Iverson Lab Prashant Singh, is a Senior Research Associate in the Iverson Lab. He’s getting used to the spotlight from his recent appearance on the YouTube channel SmarterEveryDay. However, he’s still the down-to-earth Prash, as he’s known… Read MoreMay 30, 2025
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Redefining synaptic architecture: nanoblocks as key organizing units in the postsynaptic density
Cellular function relies on the nanoscale organization of molecular components. Pre-synaptic, post-synaptic and cell adhesion proteins within the synapse are carefully organized in nanostructures to facilitate the transmission of information between neurons, a process which is essential for synaptic plasticity, learning and memory formation. However, the precise structural arrangement of… Read MoreMay 9, 2025
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CSB Research Spotlight: Wankowicz Lab – How protein movement influences function
Understanding how proteins get from point A to point B is top of mind for Stephanie Wankowicz, assistant professor of molecular physiology and biophysics. The Wankowicz lab conducts research on how entropy, a measure of the tendency toward disorder or randomness within a system, shifts when a protein… Read MoreApril 28, 2025
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CSB Spotlight: Katherine Stefanski, Sanders Lab
Katherine Stefanski, PhD, Sanders Lab Sanders Lab Postdoc Katherine Stefanski’s lab motto might be “a place for everything and everything in its place.” Outside the lab she likes to wreak a bit of havoc in Smashville! That is, when it doesn’t get in the way of a… Read MoreApril 25, 2025
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From activation to repression: decoding the impact of PPARγ ligands on ligand-binding domain conformation
Nuclear receptors (NRs) are a group of transcription factors that control gene expression in response to endogenous metabolites and synthetic ligands. Ligands bind the C-terminal ligand-binding domain (LBD) of NRs which is widely believed to alternate between transcriptionally active and repressive states and be stabilized upon ligand binding. Various X-ray… Read MoreApril 11, 2025