VISE Summer Seminar: Hernan Gonzalez and Jon Heisleman
VISE Research in Progress (RiP)
Summer Instructional Seminar Series
Date: Thursday, August 10, 2017
Location: Stevenson Center 5326
Time: 12:10 p.m. start, Noon lunch
to be delivered by
Hernan Gonzalez, doctoral candidate, department of biomedical engineering
RiP #1: Title: Multimodal Analysis of Interictal and Ictal Brain Connectivity in Temporal Lobe Epilepsy
Rip#1 (Gonzalez) Abstract: Epilepsy is a common and debilitating neurological disorder that affects nearly 1% of the global population. In temporal lobe epilepsy (TLE), the most common form of epilepsy, seizure onset is typically localized to an epileptogenic zone (EZ) in the mesial temporal lobe, and surgical resection of the EZ results in seizure freedom for many patients. Unfortunately, the negative effects of TLE are not limited to the EZ. Previous studies have shown widespread neocortical decreases in resting state functional connectivity (RSFC) in patients with TLE versus controls. Furthermore, some studies have related these RSFC decreases to neurocognitive impairments. The central hypothesis of this work is that recurrent seizures in patients with TLE result in altered connectivity between subcortical activating structures and the neocortex, leading to decreased neocortical connectivity and impaired neurocognitive function. Here I present multimodal connectivity measures in pre-operative and post-operative TLE patients, and how these relate to measures of disease severity and response to treatment.
Rip#1 (Gonzalez) Short Bio: Hernan Gonzalez graduated from the University of Miami with a BS/MS and is currently a VISE NIH T32 Fellowship Trainee and student in the Vanderbilt MSTP MD/PhD program and the Department of Biomedical Engineering. He is a member of the Vanderbilt University Institute of Imaging Science and is in the lab of Dr. Dario Englot studying connectivity in patients with epilepsy.
Jon Heiselman, PhD candidate, department of biomedical engineering
RiP #2: Title: Assessing and Compensating for Soft Tissue Deformation During Laparoscopic Liver Surgery
Rip#2 (Heiselman) Abstract: Organ deformation is an important consideration for image-guided laparoscopic liver surgery due to intraoperative practices such as abdominal insufflation and partial mobilization from supporting ligaments. Uncorrected deformation harms the ability to intraoperatively localize subsurface structures such as lesions and vessels, which cannot be identified during laparoscopy using traditional techniques such as palpation. Additionally, the nature of laparoscopic deformation is poorly characterized in humans. This talk will focus on two areas: the assessment of intraoperative deformation using a sparse surface reconstruction technique and the compensation of this deformation through a novel correction method that leverages anatomical constraints imparted by the laparoscopic surgical approach.
Rip#2 (Heiselman) Short Bio: Jon Heiselman is a current Ph.D. student and VISE trainee in the NIH T32 Training Program for Innovative Engineering Research in Surgery and Intervention. He received his B.S.E. in Biomedical Engineering from the University of Michigan in 2015 and now works with Dr. Michael Miga towards enhancing laparoscopic image guidance through computational modeling.