High Confidence Lipidomics via a Lipid Structure Atlas Enables the CIT to Predict Dysregulation

Lipids play an important role in health and disease, such as de novo lipid synthesis in cancer cell growth and survival or dysregulation of lipid metabolism in neurodegenerative diseases. Yet lipidomics research, the study of lipid species, pathways and their interactions with other metabolites inside an organism, is considered an emerging discipline. To advance the field, high-precision ion mobility-mass spectrometry resources in the CIT were utilized to develop a conformational database for lipids.

The atlas includes collision cross section information for numerous lipid classes, including: sphingomyelin, cerebroside, ceramide, phosphatidylethanolamine, phosphatidylcholine, phosphatidylserine, and phosphatidic acid. The figure below outlines the important correlations that were discovered for glycerophospholipids (PS) and sphingolipids (GlcCer). This lipid atlas is available in the CIT to help collaborators better understand the role of lipids in their specific disease.

Katrina Leaptrot, Post Doc in the McLean Lab
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Collision Cross Section Data
Metabolite Annotations
Katrina Leaptrot, Post Doc in the McLean Lab
Large Metabolomics Studies
High-Throughput Multi-Omic Analyses
qualitative amino acid panel