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Douglas Kojetin

Defining Molecular Mechanisms of Drug Action

Doug Kojetin, Biochemistry

The goal of our research is to understand how activation and repression of nuclear receptor transcription is regulated on the structural and molecular level, including the influence of small molecule ligands – natural/endogenous ligands, synthetic ligands and FDA-approved drugs used clinically. We use biomolecular NMR spectroscopy as a main structural technique, but also apply a variety of structural, computational, biophysical and functional approaches including X-ray crystallography, molecular dynamics simulations, biophysical and biochemical assays and cellular assays to connect our molecular and structural findings on nuclear receptors to cellular functions.

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