Karen Joos

Research Focus

Applications of optical techniques for sensing and performing ophthalmic surgery. A particular emphasis is the use of miniature optical coherence tomography probes for surgical image guidance.

Lab Aims

The primary aim is to develop and deploy translatable biophotonics technologies for ophthalmology. A current emphasis is the development and integration of an intraocular OCT probe to improve visualization of structures during vitreoretinal and other ophthalmic surgery, as well as the integration of these imaging probes with surgical tools and robotic-assisted control for precise tissue manipulation. Past approaches included; 1) the investigation of an OCT imaging modality in eyes with elevated IOP and 2) integration of intraocular endoscopy to improve visualization and facilitate intraocular surgery in eyes with cloudy corneas. Approaches include: histology, morphometry, immunohistochemistry, intraocular pressure response, and biomaterial delivery.

Other bench and clinical projects are glaucoma-centered research topics. Research collaborations are ongoing with multidisciplinary investigators in ophthalmology, engineering, and genetics.

Lab Members

Name	Email	Role
Jin Hui Shen	jin-hui.shen	Research Assistant Professor
Ratna Prasad	-	Research Assistant, III

Publications

Tarantola RM, Agarwal A, Lu P, Joos KM. Long-term results of combined endoscope-assisted pars plana vitrectomy and glaucoma tube shunt surgery. Retina, 31(2):275-283, 2011. PMCID: PMC3058695.

Kozub J, Ivanov B, Jayasinghe A, Prasad R, Shen J, Klosner M, Heller D, Mendenhall M, Piston D, Joos K, Hutson MS. Raman-shifted alexandrite laser for soft tissue ablation in the 6- to 7-m wavelength range. Biomedical Optic Express, 2(5):1275-1281, 2011. PMCID: PMC3087584.

Yu H, Shen JH, Joos K, and Simaan N. Design, calibration and preliminary testing of a robotic telemanipulator for OCT-guided retinal surgery. IEEE International Conference Proceedings on Robotics and Automation (ICRA'2013), peer-reviewed paper, 2013: 225–231.

Joos KM, Shen JH. Miniature real-time intraoperative forward-imaging optical coherence tomography probe. Biomedical Optics Express, 4(8):1342-1350, 2013. PMCID: PMC3756577.

Li Z, Shen J, Kozub J, Prasad R, Lu P, Joos K, A miniature forward-imaging B-scan optical coherence tomography probe to guide real-time laser ablation. Lasers in Surgery and Medicine, 46(3):193-202, 2014. PMCID: PMC3962956.

Joos KM, Shen J. Preliminary design and evaluation of a B-scan OCT-guided 36-gauge needle tip. Photonics, 1: 260-266; doi:10.3390/photonics1030260, 2014.

Yu H, Shen J, Shah R, Simaan N, Joos KM. Evaluation of microsurgical tasks with OCT-guided and/or robot-assisted ophthalmic forceps. Biomedical Optics Express, 6(2): 457–472, 2015. PMID: 25780736.

Kozub JA, Shen JH, Joos KM, Prasad R, Hutson S. Efficacy and predictability of soft tissue ablation using a prototype Raman-shifted alexandrite laser. J Biomedical Optics, 20(10):105004. doi: 10.1117/1.JBO.20.10.105004. PMID: 26456553.

Kozub J, Shen J, Joos KM, Prasad R, Hutson MS, Optic nerve sheath fenestration using a Raman-shifted alexandrite laser. Lasers in Surgery and Medicine, 48(3):270-280, 2016, doi: 10.1002/lsm.22456. PMID: 27020001, PMC: 820007. --- Journal Cover Photo

Choh V, Gurdita A, Tan B, Prasad RC, Bizheva K, Joos KM. Short-term moderately elevated intraocular pressure is associated with elevated scotopic electroretinogram responses. Investigative Ophthalmology and Visual Science, 2016; 57(4): 2140-2151. doi: 10.1167/iovs.15-18770. PMID: 27100161.

Yu H, Shen JH, Joos KM, Simaan N. Calibration and integration of B-mode optical coherence tomography for assistive control in robotic micro-surgery. Transactions in Mechatronics. 2016 June 22. [Epub ahead of print], 2016; 21(6):2613-2623. doi: 10.1109/TMECH.2016.2583259.
http://ieeexplore.ieee.org/document/7496970/.

Malone JD, El-Haddad MT, Bozic I, Tye LA, Majeau L, Godbout N, Rollins AM, Boudoux C, Joos KM, Patel SN, Tao YK. Simultaneous multimodal ophthalmic imaging using swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography. Biomed Opt Express. 2017;8(1):193-206. doi: 10.1364/BOE.8.000193. PMID: 28101411.

Del Giudice G, Wang L, Shen JH, Joos K, Simaan N. Continuum Robots for Multi-Scale Motion: Micro-Scale Motion through Equilibrium Modulation. Proceedings of the 2017 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS 2017). Sept 2017, doi: 10.1109/IROS.2017.8206074.

Tan B, Gurdita A, Choh V, Joos K, Prasad R, Bizheva K. Morphological and functional changes in the rat retina associated with 2 months of intermittent moderate intraocular pressure elevation. Scientific Reports. 2018; 8:7727 (1-11) . doi:10.1038/s41598-018-25938-zwww.nature.com/articles/s41598-018-25938-z, PMID: 29769654.