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Biophotonics Seminar Series

Upcoming Seminar

Recent events concerning the novel coronavirus has led Vanderbilt to cancel all classes and university-sponsored non-Athletics events and gatherings through April 30th. As such, we are cancelling the remaining seminars scheduled as part of the Biophotonics Seminar Series for this semester. These include Dr. Brian Applegate (03/31/2020), Dr. Donna Sessions (04/21/2020), Dr. Conor Evans (04/28/2020), and Dr. Brendan Kennedy (04/30/2020). We are currently working with our speakers to reschedule their seminars for the fall and hope to see you all then.

 

 

Presenter:

Irene Georgakoudi, Ph.D.

 

Affiliation:

Professor of Biomedical Engineering, Tufts University

 

When: 

Tuesday, March 3rd, 12:30-1:40 PM

 

Where:

Stevenson Center 5326

 

Seminar Title: 

Assessing tissue metabolic and biomechanical function through label-free, high resolution imaging

Abstract:

Histopathological tissue evaluation procedures for disease diagnosis have remained essentially unchanged for the past century. Yet, they demand highly trained personnel, significant resources and infrastructure, and provide assessments of tissue that has been highly processed. Diagnostic features rely primarily on morphological characteristics and have not evolved to incorporate a wealth of functional information that we have acquired during the last decades regarding disease development. I will present an overview of studies that we have been pursuing that aim to exploit endogenous sources of optical contrast to yield quantitative metrics of not only morphological, but also functional cell and tissue properties, without the need to excise tissue. Specifically, I will discuss the use of two-photon excited fluorescence images acquired based on detection of endogenous signal from NADH and FAD to acquire detailed information regarding changes in metabolic function. Such changes are directly related to changes in the relative levels of essential metabolic pathways and are detected in three dimensional engineered tissues, freshly excised tissues, animals and human patients in vivo. Further, I will discuss the potential of the combined use of endogenous fluorescence and scattering signatures of collagen fibers to assess subtle changes in organization and crosslinking that are associated with biomechanical changes in diseased tissues. Our ultimate goal is to perform such measurements in a manner that essentially brings the microscope to the patient enabling functional imaging to improve disease diagnosis and monitoring.

 

Future Seminars (Spring 2020)

Date Time          
Location   
Name Affiliation
March 31 12:30-1:40pm Stevenson Center 5326 Brian Applegate University of Southern California
April 9 12:30-1:40pm Stevenson Center 5326 Sam Achilefu Washington University in St. Louis
April 21 12:30-1:40pm Stevenson Center 5326 Donna Session Vanderbilt University Medical Center
April 28 12:30-1:40pm Stevenson Center 5326 Conor Evans Harvard Medical School
April 30 12:30-1:40pm Stevenson Center 5326 Brendan Kennedy University of Western Australia

For up to date announcements regarding time, location, and changes to the schedule, please join the Biophotonics Seminar listserv by emailing Graham Throckmorton.

Past Seminars

2020      
Cody Siciliano, PhD  David Levitz, PhD  Yevgenia Kozorovitskiy, PhD  Curtis Marcott, PhD
Irene Georgakoudi, PhD      
2019      
Pierre Massion, MD Justus Ndukaife, PhD Ashok Choudhury, PhD Jennifer Hunter, PhD
Christopher Valdez, PhD Mala Mahendroo, PhD Hari Schroff, PhD Maryellen Giger, PhD
Bernard Choi, PhD Richard Simerly, PhD Richard Dluhy, PhD Daniel Hammer, PhD
Shy Shoham, PhD Jennifer Hunter, PhD    
2018      
Sandra J. Rosenthal, PhD  Bryan Millis, PhD Thomas Wang, PhD, MD  Robert V. Chimenti
Mingfeng Bai, PhD Andrew Berger, PhD  Arthur F. Gmitro, PhD  Martin Leahy, PhD
Brian Pogue, PhD Andries Zijlstra, PhD  Jason Valentine, PhD Ton van Leeuwen, PhD
Alex Walsh, PhD Christine Hendon, PhD  Nick Stone, PhD  Andrew Rollins, PhD
Wolfgang Drexler, PhD      
2017      
Jeffrey D. Schall, PhD William P. Roach, PhD Stephen J. Korn, PhD Doug Morgan, MD MPH
Jerry Wilmink, PhD Laura Waller, PhD Lauren Buchanan, PhD Antony Daniels, MD
Jeff Brooker Xiaoliang Sunny Xie, PhD Peter So, PhD Dr. Joseph Izatt, PhD
Dr. Cynthia Toth, MD Bruce Tromberg, PhD Justin Baba, PhD  
       
2016      
Matthew Lang, PhD Hilliel J. Chiel, PhD Eric Grogan, MD, MPH Dylan Burnette, PhD
Ji-Xin Cheng, PhD Matthew J. Baker, PhD Eric Betzig, PhD Caroline Boudoux, PhD 
Audrey Bowden, PhD Kristin Myers, PhD  Eric Skaar, PhD, MPH Brian J. Wong, MD, PhD, FACS 
Curtiss Marcott, PhD Jay Anderson, BS  Paul Stoddart, PhD  Joshua Caldwell, PhD 
Qi Zhang, PhD J. Micheal Newton, MD, PhD  Daniel Palanker, PhD   
       
2015      
Eric R. Tkacyk, MD, PhD Xingde Li, PhD Vasan Venugopalan, ScD Andrew Dunn, PhD
Madan Jagasia, MD Mark Canales, PhD Hillel J. Chiel, PhD  

  Sponsors

SPIE Princeton
   
Andor Renishaw
   
AcFee