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VIIBRE - Publications 

Inv. Rev./Comment. | Book Chapters | Conference Proceedings Patents | Method Papers & Appl.Notes

Research Articles and Invited Reviews

May JC, Goodwin CR, McLean JA, Ion Mobility-Mass Spectrometry Strategies for Untargeted Systems, Synthetic, and Chemical Biology, Curr. Opin. Biotechnol., 31:117-121, 2015, PMCID: PMC4297680

Wilkerson I et al., Retinal Pericytes and Cytomegalovirus Infectivity: Implications for HCMV-Induced Retinopathy and Congenital Ocular Disease, J. Neuroinflammation, 12:2, 2015, PMCID: PMC4314746


Boussadia B et al., Effect of Status epilepticus and Antiepileptic Drugs on CYP2E1 Brain Expression, Neuroscience, 281C:124-134, 2014

Brown JA et al., Metabolic Consequences of Interleukin-6 Challenge in Developing Neurons and Astroglia, J. Neuroinflammation, 11:183, 2014, PMCID: PMC4233071

Byrd TF et al., The Microfluidic Multitrap Nanophysiometer for Hematologic Cancer Cell Characterization Reveals Temporal Sensitivity of the Calcein-AM Efflux Assay, Sci. Rep., 4:Article 5117, 2014, PMCID: PMC4038811

Crowder SW, Balikov DA, Hwang Y, Sung HJ, Cancer Stem Cells Under Hypoxia as a Chemoresistant Factor in Breast and Brain, Curr. Pathobiol. Rep., 2:33-40, 2014, PMCID: PMC3935368

Evans C et al., Phosphorylation of Serine 106 in Asef2 Regulates Cell Migration and Adhesion Turnover, J. Proteome Res., 13:3303-3313, 2014, PMCID: PMC4084842

Forsythe JG et al., Structural Characterization of Methylenedianiline Regioisomers by Ion Mobility-Mass Spectrometry, Tandem Mass Spectrometry, and Computational Strategies: I. Electrospray Spectra of 2-Ring Isomers, Anal. Chem., 86:4362-4370, 2014, PMCID: PMC4014176

Goodwin CR et al., Phenotypic Mapping of Metabolic Profiles Using Self-Organizing Maps of High-Dimensional Mass Spectrometry Data, Anal. Chem., 86:6561-6571, 2014, PMCID: PMC4082383

Hines KM, Ballard BR, Marshall DR, McLean JA, Structural Mass Spectrometry of Tissue Extracts to Distinguish Cancerous and Non-Cancerous Breast Diseases, Mol. BioSyst., 10:2827-2837, 2014, PMCID: PMC3267852

Hockemeyer K et al., Engineered Three-Dimensional Microfluidic Device for Interrogating Cell-Cell Interactions in the Tumor Microenvironment, Biomicrofluidics, 8:044105-1, 2014, PMCID: PMC4189212

Irvin MW, Zijlstra A, Wikswo JP, Pozzi A, Techniques and Assays for the Study of Angiogenesis, Exp. Biol. Med., 239:1476-1499, 2014 (Invited Review), PMCID: PMC4216737

Lima EA et al., Multichamber Multipotentiostat System for Cellular Microphysiometry, Sensor. Actuat. B-Chem., 204:536-543, 2014, PMCID: PMC4167374

Ly DL, Lipson H, Optimal Experiment Design for Coevolutionary Active Learning, IEEE Trans. Evol. Comput., 18:394- 404, 2014

Marasco CC et al., Systems-Level View of Cocaine Addiction: The Interconnection of the Immune and Nervous Systems, Exp. Biol. Med., 239:1433-1442, 2014 (Invited Review), PMCID: PMC4216763

Markov DA, Lillie EM, Garbett SP, McCawley LJ, Variation in Diffusion of Gases Through PDMS Due to Plasma Surface Treatment and Storage Conditions, Biomed. Microdevices, 16:91-96, 2014, PMCID: PMC3945670

May JC et al., Conformational Ordering of Biomolecules in the Gas-Phase: Nitrogen Collision Cross-Sections Measured on a Prototype High Resolution Drift Tube Ion Mobility-Mass Spectrometer, Anal. Chem., 86:2107-2116, 2014, PMCID: PMC3931330

Puvenna V et al., Significance of Ubiquitin Carboxy-Terminal Hydrolase L1 Elevations in Athletes after Sub-Concussive Head Hits, PLoS ONE, 9e96296, 2014, PMCID: PMC4012998

Wang X et al., Polymeric Stent Materials Dysregulate Macrophage and Endothelial Cell Functions: Implications for Coronary Artery Stent, Int. J. Cardiol., 4:688-695, 2014, PMCID: PMC4070878

Yan Y et al., A Microfluidic-Enabled Mechanical Microcompressor for the Immobilization of Live Single- and Multi-Cellular Specimens, Microsc. Microanal., 20:141-151, 2014, PMCID: PMC4026272

Zachman AL et al., Femtosecond Laser-Patterned Nanopore Arrays for Surface-Mediated Peptide Treatment, Nanomedicine: NBM, 10:11-14, 2014, PMCID: PMC3877160

Zachman AL et al., Uncoupling Angiogenesis and Inflammation in Peripheral Artery Disease with Therapeutic Peptide-Loaded Microgels, Biomaterials, 35:9635-9648, 2014, PMCID: PMC4164579


Alcendor et al., Neurovascular Unit on a Chip: Implications for Translational Applications, Stem Cell Res. & Ther., 4(Suppl 1):S18, 2013, PMCID: PMC4029462 

Chattopadhyay I and Lipson H, Abductive Learning of Quantized Stochastic Processes With Probabilistic Finite Automata, Phil. Trans. R. Soc. A, 371: 20110543, 2013   DOI Link

Chattopadhyay I, Kuchina A, Suel G, Lipson H, Inverse Gillespie for Inferring Stochastic Reaction Mechanisms from Intermittent Samples, PNAS 110:12990-12995, 2013, PMCID: PMC3740874 

Chowdhury S, Svec P, Wang C, Seale KT, Wikswo JP, Losert W, Gupta SK, Automated Cell Transport in Optical Tweezers-Assisted Microfluidic Chambers, IEEE T-ASE, 10:980-989, 2013 

Cornforth TW, Lipson H, Inference of Hidden Variables in Systems of Differential Equations with Genetic Programming, Genet. Program. Evolvable Mach., 14:155-190, 2013  

Crowder SW et  al., Three-Dimensional Graphene Foams Promote Osteogenic Differentiation of Human Mesenchymal Stem Cells, Nanoscale, 5:4171-4176, 2013, PMCID: PMC3672224 

Crowder SW et  al., Poly(ϵ-caprolactone)-Carbon Nanotube Composite Scaffolds for Enhanced Cardiac Differentiation of Human Mesenchymal Stem Cells, Nanomed., 8:1763-1776, 2013, PMCID: PMC3809159 

Cucullo L, Hossain M, Tierney W, Janigro D, A New Dynamic In Vitro Modular Capillaries-Venules Modular System: Cerebrovascular Physiology in a Box, BMC Neurosci., 14:18, 2013, PMCID: PMC3598202 

Deng J, Dhummakupt A, Samson P, Wikswo JP, Shor LM, Dynamic Dosing Assay Relating Real-Time Respiration Responses of Staphylococcus aureus Biofilms to Changing Microbial Conditions, Anal. Chem., 85:5411-5419, 2013

Derewacz DK et al., Antimicrobial Drug Resistance Affects Broad Changes in Metabolomic Phenotype in Addition to Secondary Metabolism, PNAS, 110, 2336-2341, 2013, PMCID: PMC3568320   DOI Link

Ghosh C et al., Expression and Functional Relevance of UGT1A4 in a Cohort of Human Drug Resistant Epileptic Brains, Epilepsia, 54:1562-1570, 2013, PMCID: PMC3805835  

Gray RA et al. Quantification of Transmembrane Currents During Action Potential Propagation in the Heart, Biophys. J., 140, 268-278, 2013, PMCID: PMC3540262   DOI Link

Gray RA et al., Transmembrane Current Imaging in the Heart During Pacing and Fibrillation, Biophys. J., 105:1710-1719, 2013, PMCID: PMC3791310  DOI Link

Guo K, Janigro D, New Immunological Approaches in Treating and Diagnosing CNS Diseases, Pharm. Pat. Anal., 2:361-371, 2013, PMCID: PMC3900298  

He B et al. Grand Challenges in Interfacing Engineering With Life Sciences and Medicine, IEEE Trans. Biomed. Eng., 60, 589-598, 2013  DOI Link

Hines KM  et al., Biomolecular Signatures of Diabetic Wound Healing by Structural Mass Spectrometry, Anal. Chem., 85:3651-3659, 2013, PMCID: PMC3622049   DOI Link

Janigro D, Iffland P, Marchi N, Granata T, A Role for Inflammation in Status epilepticus is Revealed by a Review of Current Therapeutic Approaches, Epilepsia, 54:30-32, 2013, PMCID: PMC4061983 

Jayasinghe AK, Crews SM, Mashburn DN, Hutson MS, Apical Oscillations in Amnioserosa Cells: Basolateral Coupling and Mechanical Autonomy, Biophys. J., 105:255-265, 2013, PMCID: PMC3699749

Kimmel DW, Dole WG, Cliffel DE,  Application of Multianalyte Microphysiometry to Characterize Macrophage Metabolic Responses to Oxidized LDL and the Effects of an apo-A1 Mimetic, Biochem. Biophys. Res. Commun., 431:181-185, 2013, PMCID: PMC3576722 

Kimmel DW, Meschievitz ME, Hiatt LA, Cliffel DE, Multianalyte Microphysiometry of Macrophage Responses to Phorbol Myristate Acetate, Lipopolysaccharide, and Lipoarabinomannan, Electroanalysis, 25:1706-1712, 2013  

Lee SH, Gupta MK, Bang JB,  Bae H, Sung HJ, Current Progress in Reactive Oxygen Species (ROS)-Responsive Materials for Biomedical Applications, Adv. Healthcare Mater., 2:908-915, 2013, PMCID: PMC4146500  

Marchi N, Granata T,  Janigro D, Inflammatory Pathways of Seizure Disorders, Trends Neurosci., 37:55-65, 2013, PMCID: PMC3977596

May JC, McLean JA, The Influence of Drift Gas Composition on the Separation Mechanism in Traveling Wave Ion Mobility Spectrometry from Electrodynamic Simulations, Int. J. Ion Mobil. Spec., 16:85-94, 2013, PMCID: PMC3719421   DOI Link

McLaughlin BA, Gidday JM, Poised for Success: Implementation of Sound Conditioning Strategies to Promote Endogenous Protective Responses to Stroke in Patients, Transl. Stroke Res., 4:104-113, 2013, PMCID: PMC4227500  

Shi M et al., Glia Co-Culture with Neurons in Microfluidic Platforms Promotes the Formation and Stabilization of Synaptic Contacts, Lab Chip, 13:3008-3021, 2013, PMCID: PMC3712871    

Shotwell MS, Drake KJ, Sidorov VY, Wikswo JP, Mechanistic Analysis of Challenge-Response Experiments, Biometrics, 69:741-747, 2013, PMCID: PMC4156014  

Srinivasan K et al., Delineating the Core Regulatory Elements Critical for Directed Cell Migration by Examining Folic Acid-Mediated Responses, J. Cell Sci., 126(Pt.1):221-233, 2013, PMCID: PMC3603517 

Wikswo JP et al., Scaling and Systems Biology for Integrating Multiple Organs-on-a-Chip, Lab Chip,13:3496-3511, 2013, PMCID: PMC3818688   DOI Link    PDF

Wikswo JP et al. Engineering Challenges for Instrumenting and Controlling Integrated Organ-on-a-Chip Systems, IEEE Trans. Biomed. Eng., 60, 682-690, 2013, PMCID: PMC3696887  DOI Link             Full Text

Woods MC, Uzelac I, Holcomb MR, Wikswo JP, Sidorov VY, Diastolic Field Stimulation: The Role of Shock Duration in Epicardial Activation and Propagation, Biophys. J., 105:523-532, 2013, PMCID: PMC3714876

Zachman AL, Page JM, Prabhakar G, Guelcher SA, Sung HJ, Elucidation of Adhesion-Dependent Spontaneous Apoptosis in Macrophages Using Phase Separated PEG/Polyurethane Films, Acta Biomater., 9:4964-4975, 2013, PMCID: PMC3606556

2012 :

Ashby WJ, Zijlstra A, Established and Novel Methods of Interrogating Two-Dimensional Cell Migration, Integr. Biol., 4:1338-1350, 2012, PMCID: PMC3444626  DOI Link

Ashby W, Wikswo JP, Zijlstra A, Magnetically Attachable Stencils and the Non-Destructive Analytis of the Contribution Made by the Underlying Matrix to Cell Migration, Biomaterials, 33:8189-8203, 2012  DOI Link

Chumbler NM et al., Clostridium Difficile Toxin B Causes Epithelial Cell Necrosis Through an Autoprocessing-Independent Mechanism, PLoS Pathog., 8:Article e1003072, 2012, PMCID: PMC3516567   DOI Link

Drake KJ et al., Amino Acids As Metabolic Substrates During Cardiac Ischemia, Exp. Biol. Med., 237:1369-1378, 2012, PMCID: PMC3816490   DOI Link

Enders JR et al., A Dual-Column Solid Phase Extraction Strategy for Online Collection and Preparation of Continuously Flowing Effluent Streams for Mass Spectrometry, Anal. Chem., 84:8467-8474, 2012, PMCID: PMC3518407   DOI Link

Forsythe JG et al., Semitransparent Nanostructured Films for Imaging Mass Spectrometry and Optical Microscopy, Anal. Chem., 84:10665-10670, 2012, PMCID: PMC3544556   DOI Link

Ges IA, Currie KP, Baudenbacher F, Electrochemical Detection of Catecholamine Release Using Planar Iridium Oxide Electrodes in Nanoliter Microfluidic Cell Culture Volumes, Biosens. Bioelectron., 34:30-36, 2012, PMCID: PMC3793634    DOI Link

Goodwin CR et al., Structural Mass Spectrometry: Rapid Methods for Separation and Analysis of Peptide Natural Products, J. Nat. Prod., 75:48-53, 2012, PMCID: PMC3267852   DOI Link

Harkness KM et al., Biomimetic Monolayer-Protected Gold Nanoparticles for Immunorecognition, Nanoscale, 4:3843-3851, 2012, PMCID: PMC3376232  DOI Link

Harkness KM et al., Ag-44(SR)304-: A Silver-Thiolate Superatom Complex, Nanoscale, 4:4269-4274, 2012, PMCID: PMC3518420  DOI Link

Harry RS et al., Metabolic Impact of 4-Hydroxynonenal on Macrophage-Like RAW 264.7 Function and Activation, Chem. Res. Toxicol., 25:1643-1651, 2012, PMCID: PMC3444243  DOI Link

Hiatt LA et al., A Printed Superoxide Dismutase Coated Electrode for the Study of Macrophage Oxidative Burst, Biosens. Bioelectron., 33:128-133, 2012, PMCID: PMC3291099  DOI Link

Holcomb MR et al., Continuous-Waveform Constant-Current Isolated Physiological Stimulator, Rev. Sci. Instrum., 83:044303, 2012, PMCID: PMC3331867  DOI Link

Janigro D, Are You In or Out? Leukocyte, Ion, and Neurotransmitter Permeability Across the Epileptic Blood-Brain Barrier, Epilepsia, 53 Suppl 1:26-34, 2012, PMCID: PMC4093790  DOI Link

Kimmel DW, LeBlanc G, Meschievitz ME, Cliffel DE, Electrochemical Sensors and Biosensors, Anal. Chem., 84:685-707, 2012 (Invited Review)   DOI Link

Ly DL, Lipson H, Learning Symbolic Representations of Hybrid Dynamical Systems, J. Mach. Learn. Res., 13, 3585-3618, 2012   PDF

Markov DA, Lu JP, Samson PC, Wikswo JP, McCawley LJ, Thick-Tissue Bioreactor As a Platform for Long-Term Organotypic Culture and Drug Delivery, Lab Chip, 12:4560-4568, 2012, PMCID: PMC3826880  DOI Link

Mashburn DN, Lynch HE, Ma X, Hutson MS, Enabling User-Guided Segmentation and Tracking of Surface-Labeled Cells in Time-Lapse Image Sets of Living Tissues, Cytometry A, 81A:409-418, 2012, PMCID: PMC3331924   DOI Link

Matusch A et al., Combined Elemental and Biomolecular Mass Spectrometry Imaging (MSI)  for Probing the Inventory of Tissue at the Micrometer Scale, Anal. Chem., 84:3170-3177, 2012  DOI Link

McKenzie JR, Palubinsky AM, Brown JE, McLaughlin BM, Cliffel DE, Metabolic Multianalyte Microphysiometry Reveals Extracellular Acidosis Is an Essential Mediator of Neuronal Preconditioning, ACS Chem. Neurosci., 3:510-518, 2012, PMCID: PMC3399578  DOI Link

Venkataraman R, Holcomb MR, Harder R, Knollmann BC, Baudenbacher F, Ratiometric Imaging of Calcium During Ischemia-Reperfusion Injury in Isolated Mouse Hearts Using Fura-2, Biomed. Eng. Online, 11:Article 39, 2012, PMCID: PMC3466138   


Fenn,LS and McLean,JA. Structural Resolution of Carbohydrate Positional and Structural Isomers Based on Gas-Phase Ion Mobility-Mass Spectrometry, Phys. Chem. Chem. Phys., 13, 2196-2205, 2011   DOI Link

Velkovsky,M, Snider,R, Cliffel,DE, Wikswo,JP. Modeling the Measurements of Cellular Fluxes in Microbioreactor Devices Using Thin Enzyme Electrodes, Journal of Mathematical Chemistry, 49, 251-275, 2011, PMCID: PMC3768171   DOI Link

Gupta, MK et al., Combinatorial Polymer Electrospun Matrices Promote Physiologically-Relevant Cardiomyogenic Stem Cell Differentiation, PLoS ONE, 6(12): e28935, 2011 

LeDuc,PR, Messner,WC, Wikswo,JP. How Do Control-Based Approaches Enter into Biology?, Annu. Rev. Biomed. Engr., 13, 369-396, 2011  DOI Link

Yang,R, Lenaghan,SC, Wikswo,JP, Zhang,M. External Control of the GAL Network in S. Cerevisiae:  A View From Control Theory, PloS. One., 6, e19353, 2011, PMCID: PMC3084829  DOI Link

Dukes III,AD, Samson,PC, Keene,JD, Davis,LM, Wikswo,JP, Rosenthal,SJ. Single-Nanocrystal Spectroscopy of White-Light-Emitting CdSe Nanocrystals, The Journal of Physical Chemistry A, 115, 4076-4081, 2011  DOI Link

Gao,Y, Majumdar,D, Jovanovic,B, Shaifer,C, Lin,P, Zijlstra,A, Webb,D, Li,D. A Versatile Valve-Enabled Microfluidic Cell Co-Culture Platform and Demonstration of Its Applications to Neurobiology and Cancer Biology, Biomed. Microdevices, 13, 539-548, 2011  DOI Link

Sidorov,VY, Uzelac,I, Wikswo,JP. Regional Increase of Extracellular Potassium Leads to Electrical Instability and Reentry Occurrence Through the Spatial Heterogeneity of APD Restitution, Am. J. Physiol. Heart, 301, H209-H220, 2011, PMCID: PMC3129923  DOI Link

Liu,Y, Markov,D, Wikswo,J, McCawley,L. Microfabricated Scaffold-Guided Endothelial Morphogenesis in Three-Dimensional Culture, Biomed. Microdevices, 13, 837-846, 2011  DOI Link

Schmidt,MD, Vallabhajosyula,RR, Jenkins,JW, Hood,JE, Soni,AS, Wikswo,JP, Lipson,H. Auotmated Refinement and Inference of Analytical Models for Metabolic Networks, Phys. Biol., 8, 055011 2011, PMCID: PMC4109817  DOI Link

Kerr,TJ, Gant-Branum,RL, McLean,JA. Multiplexed Analysis of Peptide Functionality Using Lanthanide-Based Structural Shift Reagents, Int. J. Mass Spectrom., 307, 28-32, 2011, PMCID: PMC3182153  DOI Link

Lubbers,B and Baudenbacher,F. Isothermal Titration Calorimetry in Nanoliter Droplets With Subsecond Time Constants, Anal. Chem., 80, 7955-7961, 2011, PMCID: PMC3737424  DOI Link

Harkness,KM et al. Nanoscale Phase Segregation of Mixed Thiolates on Gold Nanoparticles, Angew. Chem. -Int. Ed., 50, 10554-10559, 2011, PMCID: PMC3518417  DOI Link

Azevedo,D et al. DRhoGEF2 Regulates Cellular Tension and Cell Pulsations in the Amnioserosa During Drosophila Dorsal Closure, PloS. One., 6, Article e23964, 2011  DOI Link

Jayasinghe,AK, Rohner,J, Hutson,MS. Holographic UV Laser Microsurgery, Biomed. Opt. Express, 2, 2590-2599, 2011  DOI Link  


Addae-Mensah,KA, Retterer,S, Opalenik,S, Thomas,D, Lavrik,NV, Wikswo,JP. Cryogenic Etching of Silicon:  an Alternative Method for Fabrication of Vertical Microcantilever Master Molds, J. Microelectromech. S., 19, 64-74, 2010, PMCID: PMC3818692   DOI Link

Ayati,BP, Edwards,CM, Webb,GF, Wikswo,JP. A Mathematical Model of Bone Remodeling Dynamics for Normal Bone Cell Populations and Myeloma Bone Disease, Biology Direct, 5, 28 2010, PMCID: PMC2867965   DOI Link

Darby,S, Moore,M, Wikswo,JP, Reiserer,R, Friedlander,T, Schaffer,DK, Seale,KT. A Metering Rotary Nanopump for Microfluidic Systems, Lab Chip, 10, 3218-3226, 2010, PMCID: PMC4156019  DOI Link

Enders,JR, Marasco,CC, Kole,A, Nguyen,B, Sundarapandian,S, Seale,KT, Wikswo,JP, McLean,JA. Towards Monitoring Real-Time Cellular Response Using an Integrated Microfluidics-MALDI/NESI-Ion Mobility-Mass Spectrometry Platform, IET Syst. Biol., 4, 416-427, 2010, PMCID: PMC4254925   DOI Link

Gant-Branum,RL, Broussard,JA, Mahsut,A, Webb,DJ, McLean,JA. Identification of Phosphorylation Sites Within the Signaling Adaptor APPL1 by Mass Spectrometry, J. Proteome. Res., 9, 1541-1548, 2010, PMCID: PMC2845304   DOI Link

Ges,IA and Baudenbacher,F. Enzyme Electrodes to Monitor Glucose Consumption of Single Cardiac Myocytes in Sub-Nanoliter Volumes, Biosens. Bioelectron., 25, 1019-1024, 2010, PMCID: PMC4119477   DOI Link

Ges,IA and Baudenbacher,F. Enzyme-Coated Microelectrodes to Monitor Lactate Production in a Nanoliter Microfluidic Cell Culture Device, Biosens. Bioelectron., 26, 828-833, 2010  DOI Link  

Harkness,KM, Fenn,LS, Cliffel,DE, McLean,JA. Surface Fragmentation of Complexes From Thiolate Protected Gold Nanoparticles by Ion Mobility-Mass Spectrometry, Anal. Chem., 82, 3061-3066, 2010, PMCID: PMC2848286   DOI Link

Harkness,KM, Hixson,BC, Fenn,LS, Turner,BN, Rape,AC, Simpson,CA, Huffman,BJ, Okoli,TC, McLean,JA, Cliffel,DE. A Structural Mass Spectrometry Strategy for the Relative Quantitation of Ligands on Mixed Monolayer-Protected Gold Nanoparticles, Anal. Chem., 82, 9268-9274, 2010, PMCID: PMC2980554   DOI Link

Harkness,KM, Cliffel,DE, McLean,JA. Characterization of Thiolate-Protected Gold Nanoparticles by Mass Spectrometry, The Analyst, 135, 868-874, 2010, PMCID: PMC4041160   DOI Link

Jowhar,D, Wright,G, Samson,PC, Wikswo,JP, Janetopoulos,C. Open Access Microfluidic Device for the Study of Cell Migration During Chemotaxis, Integrative Biology, 2, 648-658, 2010, PMCID: PMC3806978   DOI Link

Kerr,TJ and McLean,JA. Peptide Quantitation Using Primary Amine Selective Metal Chelation Labels for Mass Spectrometry, Chem. Commun., 46, 5479-5481, 2010   DOI Link

Kliman,M, Vijayakrishnan,N, Wang,L, Tapp,JT, Broadie,K, McLean,JA. Structural Mass Spectrometry Analysis of Lipid Changes in a Drosophila Epilepsy Model Brain, Mol. Biosyst., 6, 958-966, 2010, PMCID: PMC3848785   DOI Link

Markov,DA, Samson,PC, Schaffer,DK, Dhummakup,A, Wikswo,JP, Shor,LM. Window on a Microworld: Simple Microfluidic Systems for Studying Microbial Transport in Porous Media, JoVE, 39, 2010  DOI Link

Markov,DA, Manuel,S, Shor,L, Opalenik,SR, Wikswo,JP, Samson,PC. Tape Underlayment Rotary-Node (TURN) Valves for Simple on-Chip Microfluidic Flow Control, Biomed. Microdevices, 12, 135-144, 2010, PMCID: PMC3742084   DOI Link

McBride,KK, Roth,BJ, Sidorov,VY, Wikswo,JP, Baudenbacher,FJ. Measurements of Transmembrane Potential and Magnetic Field at the Apex of the Heart, Biophys. J., 99, 3113-3118, 2010, PMCID: PMC2980705   DOI Link

McLean,JR, Mclean,JA, Wu,ZX, Becker,C, Perez,LM, Pace,CN, Scholtz,JM, Russell,DH. Factors That Influence Helical Preferences for Singly Charged Gas-Phase Peptide Ions: The Effects of Multiple Potential Charge-Carrying Sites, J. Phys. Chem. B, 114, 809-816, 2010, PMCID: PMC2818683   DOI Link

Rachakonda,G, Sekhar,K, Jowhar,D, Samson,PC, Wikswo,JP, Beauchamp,RD, Sasi,S, Datta,PK, Freeman,ML. Increased Cell Migration and Plasticity in Nrf2 Deficient Cancer Cell Lines, Oncogene, 29, 3703-3714, 2010, PMCID: PMC2892014  DOI Link

Ridenour,WB, Kliman,M, McLean,JA, Caprioli,RM. Structural Characterization of Phospholipids and Peptides Directly From Tissue Sections by MALDI Traveling-Wave Ion Mobility-Mass Spectrometry, Anal. Chem., 82, 1881-1889, 2010, PMCID: PMC2830338   DOI Link 

Seale,KT, Faley,SL, Chamberlain,J, Wikswo,JP, Jr. Macro to Nano:  A Simple Method for Transporting Cultured Cells From Milliliter Scale to Nanoliter Scale, Exp. Biol. Med., 235, 777-783, 2010, PMCID: PMC4109816  DOI Link 

Snider,RM, McKenzie,JR, Kraft,L, Kozlov,E, Wikswo,JP, Cliffel,DE. The Effects of Cholera Toxin on Cellular Energy Metabolism, Toxins, 2, 632-648, 2010, PMCID: PMC3153216   DOI Link

Sundarapandian,S, May,JC, McLean,JA. Dual Source Ion Mobility-Mass Spectrometer for Direct Comparison of Electrospray Ionization and MALDI Collision Cross Section Measurements, Anal. Chem., 82, 3247-3254, 2010, PMCID: PMC2855557   DOI Link

Brodland,GW et al. Video Force Microscopy Reveals the Mechanics of Ventral Furrow Invagination in Drosophila, PNAS (US), 107, 22111-22116, 2010  DOI Link  


Fenn,LS, Kliman,M, Mahsut,A, Zhao,SR, McLean,JA. Characterizing Ion Mobility-Mass Spectrometry Conformation Space for the Analysis of Complex Biological Samples, Analytical and Bioanalytical Chemistry, 394, 235-244, 2009, PMCID: PMC2762638   DOI Link

Irimia,A, Swinney,KR, Wikswo,JP. Partial Independence of Bioelectric and Biomagnetic Fields and Its Implications for Encephalography and Cardiography, Phys. Rev. E, 79, 051908, 2009, PMCID: PMC3818693  DOI Link

Eklund,SE, Thompson,RG, Snider,RM, Carney,CK, Wright,DW, Wikswo,J, Cliffel,DE. Metabolic Discrimination of Select List Agents by Monitoring Cellular Responses in a Multianalyte Microphysiometer, Sensors, 9, 2117-2133, 2009, PMCID: PMC3345856   DOI Link

Ma,X, Lynch,H, Scully,PC, Hutson,MS. Probing Embryonic Tissue Mechanics With Laser Hole Drilling. Physical Biology, 6, 036004, 2009  DOI Link

An,SS, Kim,J, Ahn,K, Trepat,X, Drake,KJ, Kumar,S, Ling,G, Purington,C, Rangasamy,T, Kensler,TW et al. Cell Stiffness, Contractile Stress and the Role of the Extracellular Matrix, Biochem. Biophys. Res. Commun., 382, 697-703, 2009, PMCID: PMC2956180  DOI Link

Botzolakis,EJ, Maheshwari,A, Feng,HJ, Lagrange,AH, Shaver,JH, Kassebaum,NJ, Venkataraman,R, Baudenbacher,F, MacDonald,RL. Achieving Synaptically Relevant Pulses of Neurotransmitter Using PDMS Microfluidics, J. Neurosci. Methods, 177, 294-302, 2009   DOI Link

Elzie,CA, Colby,J, Sammons,MA, Janetopoulos,C. Dynamic Localization of G Proteins in Dictyostelium Discoideum, J. Cell Sci., 122, 2597-2603, 2009  DOI Link

Faley,SL, Copland,M, Wlodkowic,D, Kolch,W, Seale,KT, Wikswo,JP, Cooper,JM. Microfluidic Single Cell Arrays to Interrogate Signalling Dynamics of Individual, Patient-Derived Hematopoietic Stem Cells, Lab Chip, 9, 2659-2664, 2009  DOI Link

Gray,RA, Wikswo,JP, Otani,NF. Origin Choice and Petal Loss in the Flower Garden of Spiral Wave Tip Trajectories, Chaos, 19, 033118 2009, PMCID: PMC2748696   DOI Link

McLean,JA. The Mass-Mobility Correlation Redux:  the Conformational Landscape of Anhydrous Biomolecules, J. Am. Soc. Mass. Spect., 20, 1775-1781, 2009  DOI Link

Gant-Branum,RL, Kerr,TJ, McLean,JA. Labeling Strategies in Mass Spectrometry-Based Protein Quantitation, Analyst, 134, 1525-1530 (2009) 10.1039/B904643G   DOI Link

Easley,CJ, Benninger,RKP, Shaver,JH, Steven Head,W, Piston,DW. Rapid and Inexpensive Fabrication of Polymeric Microfluidic Devices Via Toner Transfer Masking, Lab Chip, 9, 1119-1127, 2009   DOI Link

Enders,JR and McLean,JA. Chiral and Structural Analysis of Biomolecules Using Mass Spectrometry and Ion Mobility-Mass Spectrometry, Chirality, 21, E253-E264, 2009   DOI Link

Fenn,LS and McLean,JA. Simultaneous Glycoproteomics on the Basis of Structure Using Ion Mobility-Mass Spectrometry, Mol. Biosyst., I5, 1298-1302, 2009   DOI Link

Holcomb,MR, Woods,MC, Uzelac,I, Wikswo,JP, Gilligan,JM, Sidorov,VY. The Potential of  Dual Camera System for Multimodal Imaging of Cardiac Electrophysiology and Metabolism, Exp. Biol. Med., 234, 1355-1373, 2009, PMCID: PMC3816393   DOI Link

Wlodkowic,D, Faley,S, Zagnoni,M, Wikswo,JP, Cooper,JM. Microfluidic Single-Cell Array Cytometry for the Analysis of Tumour Apoptosis, Anal. Chem., 81, 5517-5523, 2009, PMCID: PMC3816605   DOI Link

Hutson,MS, Veldhuis,J, Ma,X, Lynch,HE, Cranston,PG, Brodland,GW. Combining Laser Microsurgery and Finite Element Modeling to Assess Cell-Level Epithelial Mechanics, Biophys. J., 97, 3075-3085, 2009  DOI Link

Phelan,VV et al. Adenylation Enzyme Characterization Using G-18O4-ATP Pyrophosphate Exchange, Chemistry & Biology, 16, 473-478, 2009  DOI Link  


Wang,W, Shor,LM, LeBoeuf,EJ, Wikswo,JP, Taghon,GL, Kosson,DS. Protozoan Migration in Bent Microfluidic Channels, Appl. Environ. Microbiol., 74, 1945-1949, 2008, PMCID: PMC2268297   DOI Link

Gorman,BR and Wikswo,JP, Characterization of Transport in Microfluidic Gradient Generator, Microfluidics and Nanofluidics,  4, 273-285, 2008   DOI Link

Abbas,RA, Lin,S-F, Mashburn,D, Xu,J, Wikswo,JP, A Phased-Array Stimulator System for Studying Planar and Curved Cardiac Activation Wave Fronts, IEEE Trans. Biomed. Eng., 55: 222-229, 2008, PMCID: PMC2742885  DOI Link

Georgescu W, Jourquin J, Estrada L, Anderson ARA, Quaranta V, Wikswo JP, Model-Controlled Hydrodynamic Focusing to Generate Multiple Overlapping Gradients of Surface-Immobilized Proteins in Microfluidic Devices, Lab on a Chip, 8: 238-244,  2008  DOI Link

Evertson,DW, Holcomb,MR, Eames,M, Bray,M, Sidorov,VY, Xu,J, Wingard,H, Dobrovolny,HM, Woods,MC, Gauthier,DJ et al. High-Resolution High-Speed Panoramic Cardiac Imaging System, IEEE Trans. Biomed. Eng., 55, 1241-1243, 2008, PMCID: PMC2561274   DOI Link

Snider,RM, Ciobanu,M, Rue,AE, Cliffel,DE, A Multiwalled Carbon Nanotube/Dihydropyran Composite Film Electrode for Insulin Detection in a Microphysiometer Chamber, Anal.Chim.Acta, 609: 44-52, 2008, PMCID: PMC2358927  DOI Link

Ges,IA, Dzhura,IA, Baudenbacher,FJ. On-Chip Acidification Rate Measurements From Single Cardiac Cells Confined in Sub-Nanoliter Volumes, Biomed. Microdevices, 10, 347-354, 2008, PMCID: PMC4243529  DOI Link

Xu,J, Reiserer,R, Tellinghuisen,J, Wikswo,JP, Baudenbacher,FJ. A Microfabricated Nanocalorimeter:  Design, Characterization, and Chemical Calibration, Anal. Chem., 80, 2728-2733, 2008, PMCID: PMC4155943   DOI Link

Jayagopal,A, Sussman,EM, Shastri,VP. Functionalized Solid Lipid Nanoparticles for Trans-Endothelial Delivery, IEEE Trans. NanoBiosci., 7, 28-34, 2008   DOI Link

Diniz Oliveira,HF, Weiner,AA, Majumdar,A, Shastri,VP. Non-Covalent Surface Engineering of an Alloplastic Polymeric Bone Graft Material for Controlled Protein Release, Journal of Controlled Release, 126, 237-245, 2008   DOI Link

Gruver,JS, Wikswo,JP, Chung,CY. 3'-Phosphoinositides Regulate the Coordination of Speed and Accuracy During Chemotaxis, Biophys. J., 95, 4057-4067, 2008, PMCID: PMC2553113   DOI Link

Liu,Y, Sai,JG, Richmond,A, Wikswo,JP. Microfluidic Switching System for Analyzing Chemotaxis Responses of Wortmannin-Inhibited HL-60 Cells, Biomed. Microdevices, 10, 499-507, 2008, PMCID: PMC2668251  DOI Link

Harris,MP, Kim,E, Weidow,B, Wikswo,JP, Quaranta,V. Migration of Isogenic Cell Lines Quantified by Dynamic Multivariate Analysis of Single-Cell Motility, Cell Adhesion & Migration, 2, 127-136, 2008, PMCID: PMC2634586   DOI Link

Fenn,LS and McLean,JA. Biomolecular Structural Separations by Ion Mobility-Mass Spectrometry, Anal. Bioanal. Chem., 391, 905-909 (2008)   DOI Link

Fenn,LS and McLean,JA. Enhanced Carbohydrate Structural Selectivity in Ion Mobility-Mass Spectrometry Analyses by Boronic Acid Derivatization, Chem. Commun., Issue 43, 5505-5507 (2008)  DOI Link

Gies,AP, Kliman,M, McLean,JA, Hercules,DM. Characterization of Branching in Aramid Polymers Studied by MALDI-Ion Mobility/Mass Spectrometry, Macromolecules, 41, 8299-8301 (2008)  DOI Link

Sai,J, Raman,D, Liu,Y, Wikswo,J, Richmond,A. Parallel Phosphatidylinositol 3-Kinase (PI3K)-Dependent and Src-Dependent Pathways Lead to CXCL8-Mediated Rac2 Activation and Chemotaxis, J. Biol. Chem., 283, 26538-26547, 2008, PMCID: PMC2546539  DOI Link

Ges,IA and Baudenbacher,F. Microfluidic Device to Confine Single Cardiac Myocytes in Sub-Nanoliter Volumes for Extracellular PH Measurements, J. Exp. Nanosci., 3, 63-75, 2008 DOI Link

Ciobanu,M, Taylor,DE, Wilburn,JP, Cliffel,DE. Glucose and Lactate Biosensors for Scanning Electrochemical Microscopy Imaging of Single Live Cells, Anal. Chem., 80, 2717-2727, 2008, PMCID: PMC2836715   DOI Link

Irimia,A and Wikswo,JP, Jr. Gastrointestinal Arrhythmias Are Associated With Statistically Significant Fluctuations in Systemic Information Dimension, Physiol. Meas., 29, N33-N40, 2008   DOI Link

Faley,S, Seale,K, Hughey,J, Schaffer,DK, VanCompernolle,S, McKinney,B, Baudenbacher,F, Unutmaz,D, Wikswo,JP. Microfluidic Platform for Real-Time Signaling Analysis of Multiple Single T Cells in Parallel, Lab Chip, 8, 1700-1712, 2008, PMCID: PMC4160168   DOI Link

Sidorov,VY, Holcomb,MR, Woods,MC, Gray,RA, Wikswo,JP. Effects of Unipolar Stimulation on Voltage and Calcium Distributions in the Isolated Rabbit Heart, Basic Research in Cardiology, 103, 537-551, 2008, PMCID: PMC2742888  DOI Link

Seale,KT, Reiserer,RS, Markov,DA, Ges,IA, Wright,C, Janetopoulos,C, Wikswo,JP. Mirrored Pyramidal Wells for Simultaneous Mutiple Vantage Point Microscopy, J. Microsc., 232, Pt.1, 1-6, 2008   DOI Link

Holcomb,MR, Bekele,RY, Lima,EA, Wikswo,JP. USB-Powered and -Controlled Isolated Constant-Current Physiological Stimulator, Rev. Sci. Instrum., 79, 126103 2008, PMCID: PMC2736648  DOI Link

Maleckar,MM, Woods,MC, Sidorov,VY, Holcomb,MR, Mashburn,DN, Wikswo,JP, Trayanova,NA. Polarity Reversal Lowers Activation Time During Diastolic Field Stimulation of the Rabbit Ventricles: Insights into Mechanisms, Am. J. Physiol. Heart, 295, H1626-H1633, 2008, PMCID: PMC2593523  DOI Link

Benninger,RKP, Zhang,M, Head,WS, Satin,LS, Piston,DW. Gap Junction Coupling and Calcium Waves in the Pancreatic Islet, Biophys. J., 95, 5048-5061, 2008   DOI Link

Hutson,MS, Brodland,GW, Yang,J, Viens,D. Cell Sorting in Three Dimensions: Topology, Fluctuations, and Fluidlike Instabilities, Phys. Rev. Lett., 101, 148105 2008   DOI Link

Hutson,MS. Physical Aspects of Developmental Biology: 21st Century Perspectives 'On Growth and Form' - Preface, Physical Biology, 5, E01 2008   DOI Link

Hutson,MS and Ma,XY. Mechanical Aspects of Developmental Biology: Perspectives On Growth and Form in the (Post)-Genomic Age, Physical Biology, 5, 015001 2008   DOI Link

Xiao,Y, Guo,M, Zhang,P, Shanmugam,G, Polavarapu,PL, Hutson,MS. Wavelength-Dependent Conformational Changes in Collagen After Mid-Infrared Laser Ablation of Cornea, Biophys. J., 94, 1359-1366, 2008   DOI Link

Werdich,AA, Lima,EA, Dzhura,I, Singh,MV, Li,J, Anderson,ME, Baudenbacher,FJ. Differential Effects of Phospholamban and Ca2+/Calmodulin-Dependent Kinase II on [Ca2+]i Transients in Cardiac Myocytes at Physiological Stimulation Frequencies, Am. J. Physiol. Heart, 294, 2352-2362, 2008   DOI Link

Baudenbacher,F, Schober,T, Pinto,JR, Sidorov,VY, Hilliard,F, Solaro,RJ, Potter,JD, Knollmann,BC. Myofilament Ca2+ Sensitization Causes Susceptibility to Cardiac Arrhythmia in Mice, J. Clin. Invest., 118, 3893-3903, 2008  DOI Link

Weiss,BP, Fong,LE, Vali,H, Lima,EA, Baudenbacher,FJ. Paleointensity of the Ancient Martian Magnetic Field, Geophys. Res. Lett., 35, L23207 2008  DOI Link  


Addae-Mensah,KA, Kassebaum,NJ, Bowers,MJ, II, Reiserer,RS, Rosenthal,SJ, Moore,PE, Wikswo,JP, A Flexible, Quantum Dot-Labeled Cantilever Post Array for Studying Cellular Microforces, Sensors and Actuators A-Physical, 136: 385-397, 2007  DOI Link

Addae-Mensah,KA, Reiserer,RS, Wikswo,JP, Poly(Vinyl Alcohol) As a Structure Release Layer for Microfabrication of Polymer Composite Structures, J Micromech Microeng, 17: N41-N46, 2007  DOI Link

Bornhop,DJ, Latham,JC, Kussrow,A, Markov,DA, Jones,RD, Sorensen,HS , Free-Solution, Label-Free Molecular Interactions Studied by Back-Scattering Interferometry, Science, 317: 1732-1736, 2007  DOI Link

Ges,IA, Ivanov,BL, Werdich,AA, Baudenbacher,FJ, Differential pH Measurements of Metabolic Cellular Activity in Nl Culture Volumes Using Microfabricated Iridium Oxide Electrodes, Biosens Bioelectronics, 22: 1303-1310, 2007  DOI Link

Lipski,AM, Jacquiery,C, Choi,H, Eberli,D, Stevens,MM, Martin,I, Chen,I-W,  Shastri,VP, Nanoscale engineering of biomaterial surfaces, Advanced Materials, 19(4): 553-557, 2007  DOI Link

Hutson, MS and Ma, X , Plasma and Cavitation Dynamics during Pulsed Laser Microsurgery In Vivo, Phys Rev Lett, 99, 158104, 2007  DOI Link

Mishra,A, Lu,Y, Choe,AS, Aldroubi,A, Gore,JC, Anderson,AW, Ding,Z, An Image-Processing Toolset for Diffusion Tensor Tractography, Magn Reson Imaging, 25: 365-376, 2007  DOI Link

Sussman,E, Clarke,MB, Shastri,VP, A Single Step Process to Produce Surface-Functionalized Nanoparticles from Non-Functionalized Degradable Polymers, Langmuir, 23(24): 12275-12279, 2007  DOI Link

Vajandar,SK, Xu,D, Markov,D, Wikswo,JP, Hofmeister,W, Li,D, SiO2-Coated Porous Anodic Alumina Membrane for Electroosmotic Pumping, Nanotechnology, 18,  275705, 2007  DOI Link

McLean,JA, Ridenour,WB, Caprioli,RM. Profiling and Imaging of Tissues by Imaging Ion Mobility-Mass Spectrometry, J. Mass Spectrom., 42, 1099-1105 (2007) 10.1002/jms.1254  DOI Link

Weiner,AA, Shuck,D, Bush,J, Shastri,VP, Optimization of photocrosslinked anhydride systems for bone augmentation applications: characterization of in vitro degradation, Biomaterials, 28: 5259-5270, 2007  DOI Link

Xu,X, Shastri,VP, A Modular Approach to the Synthesis of Property-Tunable Biodegradable Polyesters Derived from Poly(e-Caprolactone), Corrosion Engineering Science and Technology, 42(4): 293-299 (Invited Paper), 2007  DOI Link

Mashburn DN, Hinkson SJ, Woods MC, Gilligan JM, Holcomb MR, Wikswo JP, A High-Voltage Cardiac Stimulator for Field Shocks of a Whole Heart in a Bath, Review of Scientific Instruments, 78, 104302, 2007  DOI Link

Sidorov VY, Woods MC, Baudenbacher F., Cathodal Stimulation in the Recovery Phase of a Propagating Planar Wave in the Rabbit Heart Reveals Four Stimulation Mechanisms., J Physiol, 583(Pt 1):237-250, 2007, PMCID: PMC2277246  DOI Link

Werdich AA, Baudenbacher F, Dzhura I, Jeyakumar LH, Kannankeril PJ, Fleischer S, LeGrone A, Milatovic D, Aschner M, Strauss AW, Anderson ME, Exil VJ., Polymorphic ventricular tachycardia and abnormal Ca2+ handling in very-long-chain acyl-CoA dehydrogenase null mice, Am J Physiol Heart Circ Physiol, 292(5):H2202-H2211, 2007  DOI Link

Edwards,GS, Pearlstein,RD, Copeland,ML, Hutson,MS, Latone,K, Spiro,A, Pasmanik,G. 6450 Nm Wavelength Tissue Ablation Using a Nanosecond Laser Based on Difference Frequency Mixing and Stimulated Raman Scattering, Opt. Lett., 32, 1426-1428, 2007   DOI Link

Peralta,XG, Toyama,Y, Hutson,MS, Montague,R, Venakides,S, Kiehart,DP, Edwards,GS. Upregulation of Forces and Morphogenic Asymmetries in Dorsal Closure During Drosophila Development, Biophys. J., 92, 2583-2596, 2007  DOI Link

Weiss,BP, Lima,EA, Fong,LE, Baudenbacher,FJ. Paleointensity of the Earth's Magnetic Field Using SQUID Microscopy, Earth and Planetary Science Letters, 264, 61-71, 2007  DOI Link  


Eklund,SE, Snider,RM, Wikswo,J, Baudenbacher,F, Prokop,A, Cliffel,DE, Multianalyte Microphysiometry as a Tool in Metabolomics and Systems Biology, J Electroanal Chem, 587: 333-339, 2006  DOI Link

Sai,JG, Walker,G, Wikswo,J, Richmond,A, The IL Sequence in the LLKIL Motif in CXCR2 is Required for Full Ligand Induced Activation of ERK, AKT and Chemotaxis in HL60 Cells, J Biol Chem, 281: 35931-35941, 2006  DOI Link

Shastri,VP, Future of regenerative medicine: Challenges and hurdles, Artificial Organs, 30(10):  828-834 (Invited Paper), 2006  DOI Link

Warnement,MR, Faley,SL, Wikswo,JP, Rosenthal,SJ, Quantum Dot Probes for Monitoring Dynamic Cellular Response:  Reporters of T Cell Activation, IEEE Trans Nanobiosci, 5: 268-272, 2006  DOI Link

Xu,XJ, Sy,JC, Shastri,VP , Towards developing surface eroding poly(alpha-hydroxy acids, Biomaterials, 27: 3021-3030, 2006  DOI Link

Gattacceca,J, Boustie,M, Weiss,BP, Rochette,P, Lima,EA, Fong,LE, Baudenbacher,FJ. Investigating Impact Demagnetization Through Laser Impacts and SQUID Microscopy, Geology, 34, 333-336, 2006  DOI Link

Xiao,Y, Guo,M, Parker,K, Hutson,MS. Wavelength-Dependent Collagen Fragmentation During Mid-IR Laser Ablation, Biophys. J., 91, 1424-1432, 2006   DOI Link  


Ges,IA, Ivanov,BL, Schaffer,DK, Lima,EA, Werdich,AA, Baudenbacher,FJ, Thin-Film IrOx pH Microelectrode for Microfluidic-Based Microsystems, Biosensors & Bioelectronics, 21: 248-256, 2005  DOI Link

Fong,LE, Holzer,JR, McBride,KK, Lima,EA, Baudenbacher,F, Radparvar,M, High-Resolution Room-Temperature Sample Scanning Superconducting Quantum Interference Device Microscope Configurable for Geological and Biomagnetic Applications, Rev Sci Instrum , 76, 053703, 2005  DOI Link

Walker,GM, Sai,JG, Richmond,A, Stremler,MA, Chung,CY, Wikswo,JP, Effects of Flow and Diffusion on Chemotaxis Studies in a Microfabricated Gradient Generator, Lab on a Chip, 5: 611-618, 2005, PMCID: PMC2665275  DOI Link

Wang,W, Shor,LM, LeBoeuf,EJ, Wikswo,JP, Kosson,DS, Mobility of Protozoa Through Narrow Channels, Appl Environ Microbiol, 71: 4268-4637, 2005  DOI Link

Yang,Z, Shen,W, Rottman,JN, Wikswo,JP, Murray,KT, Rapid Stimulation Causes Electrical Remodeling in Cultured Atrial Myocytes, J Mol Cell Cardiol, 38: 299-308, 2005  DOI Link

Baudenbacher F, Fong LE, Thiel G, Wacke M, Jazbinsek V, Holzer JR, Stampfl A, Trontelj Z., Intracellular axial current in Chara corallina reflects the altered kinetics of ions in cytoplasm under the influence of light, Biophysical J, 88(1):690-697, 2005  DOI Link

Sidorov VY, Woods MC, Baudenbacher P, Baudenbacher F., Examination of Stimulation Mechanism and Strength-Interval Curve in Cardiac Tissue, Am J Physiol Heart Circ Physiol, 289(6):H2602-H615, 2005  DOI Link  


Werdich,A, Lima,EA, Ivanov,B, Ges,I, Wikswo,JP, Baudenbacher,FJ, A Microfluidic Device to Confine a Single Cardiac Myocyte in a Sub-Nanoliter Volume on Planar Microelectrodes for Extracellular Potential Recordings, Lab on a Chip, 4: 357-362, 2004  DOI Link

Chancellor,EB, Wikswo,JP, Baudenbacher,F, Radparvar,M, Osterman,D, Heat Conduction Calorimeter for Massively Parallel High Throughput Measurements with Picoliter Sample Volumes, Appl Phys Lett, 85: 2408-2410, 2004  DOI Link

Eklund,SE, Taylor,D, Kozlov,E, Prokop,A, Cliffel,DE, A Microphysiometer for Simultaneous Measurement of Changes in Extracellular Glucose, Lactate, Oxygen, and Acidification Rate, Anal Chem, 76: 519-527, 2004  DOI Link

Prokop,A, Prokop,Z, Schaffer,D, Kozlov,E, Wikswo,JP, Cliffel,D, Baudenbacher,F, NanoLiterBioReactor:  Long-Term Mammalian Cell Culture at Nanofabricated Scale, Biomed Microdevices, 6: 325-339, 2004  DOI Link

Rocheleau,JV, Walker,GM, Head,WS, McGuinness,OP, Piston,DW, Microfluidic Glucose Stimulation Reveals Limited Coordination of Intracellular Ca2+ Activity Oscillations in Pancreatic Islets, PNAS, 101:12899-12903, 2004  DOI Link

Holzer JR, Fong LE, Sidorov VY, Wikswo JP Jr, Baudenbacher F., High Resolution Magnetic Images of Planar Wave Fronts Reveal Bidomain Properties of Cardiac Tissue, Biophysical J, 87(6):4326-32, 2004, PMCID: PMC1304939  DOI Link

Eklund,S and Cliffel,DE. Synthesis and Catalytic Properties of Soluble Platinum Nanoparticles Protected by a Thiol Monolayer, Langmuir, 20, 6012-6018, 2004  DOI Link


Baudenbacher,F, Fong,LE, Holzer,JR, Radparvar,M, Monolithic Low-Transition-Temperature Superconducting Magnetometers for High Resolution Imaging Magnetic Fields of Room Temperature Samples, Appl Phys Lett, 82: 3487-3489, 2003   DOI Link

Eklund,SE, Cliffel,DE, Kozlov,E, Prokop,A, Wikswo,JP, Jr., Baudenbacher,FJ, Modification of the Cytosensor TM Microphysiometer to Simultaneously Measure Extracellular Acidification and Oxygen Consumption Rates, Anal Chim Acta, 496:93-101, 2003  93-101, 2003  DOI Link  

Invited Reviews and Commentaries 

Wikswo JP, Porter AP, Biology Coming Full Circle: Joining the Whole and the Parts, Exp. Biol. Med, 240:3-7, 2015  Full Text

Hummel S, Quaranta V, Wikswo JP, The Biohacker: A Threat to National Security, CTC Sentinel, 7:8-11, 2014

Lee SH et al., ROS-Cleavable Proline Oligomer Crosslinking of Polycaprolactone for Pro-Angiogenic Host Response, J. Mater. Chem. B, 2:7109-7113, 2014 doi: 10.1039/C4TB01094A

Wikswo JP, The Relevance and Potential Roles of Microphysiological Systems in Biology and Medicine, Exp. Biol. Med., Annual Thematic Issue: The Biology and Medicine of Microphysiological Systems, 239:1061-1072, 2014   Full Text Link

Gray,RA and Wikswo,JP. Cardiovascular Disease: Several Small Shocks Beat One Big One, Nature, 475, 181-182, 2011  DOI Link

Enders,JR, Goodwin,CR, Marasco,CC, Seale,KT, Wikswo,JP, McLean,JA. Advanced Structural Mass Spectrometry for Systems Biology:  Pulling the Needles From Haystacks, Spectroscopy Supp. Curr. Trends Mass Spectrometry, July, 18-23, 2011  Full Text Link

Kliman,M, May,JC, McLean,JA. Lipid Analysis and Lipidomics by Structurally Selective Ion Mobility-Mass Spectrometry, Biochimica Et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1811, 935-945, 2011, PMCID: PMC3326421  DOI Link

Seale,K, Janetopoulos,C, Wikswo,J. Micro-Mirrors for Nanoscale Three-Dimensional Microscopy, Acs Nano, 3, 493-497, 2009   DOI Link

Addae-Mensah,KA and Wikswo,JP. Measurement Techniques for Cellular Biomechanics In Vitro, Experimental Biology and Medicine, 233, 792-809, 2008  DOI Link

Huang,S and Wikswo,J, Dimensions of Systems Biology, Reviews of Physiology, Biochemistry and Pharmacology, Amara,SG, Bamberg,E, Gudermann,T, Hebert,SC, Jahn,R, Lederer,WJ, Lill,R, Miyajima,A, Offermanns,S, Eds, 81-104, 2006  DOI Link

Wikswo,JP, Prokop,A, Baudenbacher,F, Cliffel,D, Csukas,B, Velkovsky,M, The Engineering Challenges of BioNEMS: The Integration of Microfluidics, and Micro- and Nanodevices, Models, and External Control for Systems Biology, IEE Proceedings Nanobiotechnology, 153: 81-101, 2006  DOI Link  

Methods Papers and Application Notes

Georgescu,W, Wikswo,JP, Quaranta,V. Cell Animation:  An Open Source MATLAB Framework for Microscopy Assays, Bioinformatics, 28, 138-139, 2012  DOI Link

Newaz,AKM et al. Graphene Transistor As a Probe for Streaming Potential, Nano Let., 12, 2931-2935, 2012  DOI Link

Markov,DA, Lillie,EM, Samson,PC, Wikswo,JP, McCawley,LJ. A Method for Periodic Sterile Sample Collection During Continuous Cell Culture in Microfluidic Devices, Lab Chip,, 2010

Greene,J, Henderson,JW, Jr., Wikswo,JP. Rapid and Precise Determination of Cellular Amino Acid Flux Rates Using HPLC With Automated Derivatization With Absorbance Detection. Application Note, 5990-3283EN, Agilent Technologies , 2009   Full Text Link  

Book Chapters

Iffland PH, Grant GA, Janigro D, Mechanisms of Cerebral Edema Leading to Early Seizures after Traumatic Brain Injury, in Vascular Mechanisms in CNS Trauma, Eng H. Lo, Josephine Lok, MingMing Ning, Michael J. Whalen, Eds., Springer Series in Translational Stroke Research, Vol. 5, pp. 29-45, 2014   doi: 10.1007/978-1-4614-8690-9_2

McKenzie JR, Cliffel DE, Wikswo JP, Electrochemical Monitoring of Cellular Metabolism, in Encyclopedia of Applied Electrochemistry, Savinell,R Ota,K, and Kreysa,G, Eds., Springer-Verlag Heidelberg, 2013

Fenn,LS and McLean,JA. Structural separations by Ion Mobility-MS for Glycomics and Glycoproteomics. In: Mass spectrometry of glycoproteins: methods and protocols, Methods in molecular biology, Kohler,J and Patrie,SM, eds. Humana Press, New York, 171-193, 2013   DOI Link

May,JC, Goodwin,CR, McLean,JA. Gas-Phase Ion Mobility-Mass Spectrometry (IM-MS) and Tandem IM-MS/MS Strategies for Metabolism Studies and Metabolomics. In: Encyclopedia of drug metabolism and interactions, Lyubimov,AV, ed. Wiley, Hoboken, N.J., 1-29, 2012   DOI Link

Hines,KM, Enders,JR, McLean,JA. Multidimensional Separations by Ion Mobility-Mass Spectrometry. In: Encyclopedia of Analytical Chemistry (on-line), Myers,RA and Muddiman,D, eds. John Wiley & Sons, Ltd, doi: 10.1002/9780470027318.a9313, 2012   DOI Link

Schmidt,M and  Lipson,H. Age-Fitness Pareto Optimization. In: Genetic programming theory and practice VIII, Riolo,R, McCongahy,T, Vladislavleva,E, eds. Springer, New York, 129-146, 2011   DOI Link

Enders,JR, Kliman,M, Sundarapandian,S, McLean,JA. Peptide and Protein Analysis Using Ion Mobility-Mass Spectrometry. In: Peptide and Protein Mass Spectrometry in Drug Discovery, Gross,ML, Chen,G, Pramanik,B, eds. J. Wiley & Sons, 139-174, 2011  DOI Link

McLean,JA, Schultz,JA, Woods,AS. Ion Mobility-Mass Spectrometry for Biological and Structural Mass Spectrometry. In: Electrospray and MALDI mass spectrometry: fundamentals, instrumentation, practicalities, and biological applications, Cole,RB, ed. Wiley, Hoboken, N.J., 411-439, 2010

May,JC and McLean,JA. The Conformational Landscape of Biomolecules in Ion Mobility-Mass Spectrometry. In: Ion Mobility Spectrometry-mass Spectrometry: Theory and applications, Wilkins,CL and Trimpin,S, eds. CRC Press, Boca Raton, FL, 327-343, 2010

McLean,JA, Fenn,LS, Enders,JR. Structurally Selective Imaging Mass Spectrometry by Imaging Ion Mobility-Mass Spectrometry. In: Mass Spectrometric Imaging:  History, Fundamentals and Protocols, Sweedler,JV and Rubakhin,SS, eds. Humana Press, New York, 363-383, 2010  DOI Link

Wikswo,JP and Roth,BJ. Virtual Electrode Theory of Pacing. In: Cardiac bioelectric therapy:  Mechanisms and practical implications, Efimov,I, Kroll,M, Tchou,P, eds. Springer,  283-330, 2009   DOI Link

Rocheleau,JV and Piston,DW. Combining Microfluidics and Quantitative Fluorescence Microscopy to Examine Pancreatic Islet Molecular Physiology. In: Methods in Cell Biology, Correia,JJ and Detrich,HW, eds. Elsevier,  71-92, 2008   DOI Link

Jayagopal,A,  Shastri,VP, Nanoengineering of Drug Delivery Systems, in Nanoparticulate Drug Delivery Systems, Thassu,D, Deleers,M, Pathak,Y, Eds., Informa Heathcare, NY,  Chp. 7, 99-110, 2007

Jayagopal,A,  Shastri,VP, Nanoscale Engineering of Biomaterial Surfaces, in Nanotechnologies for the Life Sciences, Volume 8: Nanotechnologies for Tissue, Cell and Organ Engineering, Kumar,C, Ed., Wiley-VCH , Chapter 12, 461-505, 2006  DOI Link

Eklund,SE, Kozlov,E, Taylor,DE, Baudenbacher,F, Cliffel,DE, Real-Time Cell Dynamics With a Multianalyte Physiometer, in NanoBiotechnology Protocols, Rosenthal,S and Wright,D, eds. Humana Press, Totawa, NJ, 209-223, 2005  DOI Link  


Wikswo,JP, Baudenbacher,FJ, Cliffel,DE, Haselton,FR, LeBoeuf,EJ, Prokop,A, Reiserer,RS, Stremler,MA, Bioreactors With Multiple Chambers, Pat.No. 7,977,089 B2, July 12, 2011   Full Text Link

Seale,KT, Reiserer,RS, Wikswo,JP, Photolithographed Micro-Mirror Well for 3D Tomogram Imaging of Individual Cells, US Pat.No. 7,974,003 B2, July 5, 2011   Full Text Link

Wikswo,JP, Baudenbacher,FJ, McGuinness,O, Device and Methods for Monitoring the Status of at Least One Cell, US Pat.No. 7,981,649 B2, July 19, 2011   Full Text Link

Wikswo,JP, Baudenbacher,FJ, Prokop,A, LeBoeuf,EJ, Chung,CY, Cliffel,DE, Haselton,FR, Hofmeister,WH, Lin,CP, McCawley,LJ, Reiserer,RS, Stremler,MA, Capillary Perfused Bioreactors With Multiple Chambers, US Pat.No. 8,003,378 B2, Aug. 23, 2011   Full Text Link

Cliffel,D, Baudenbacher,FJ, Wikswo,JP, Eklund,S, Balcarcel,RR, Gilligan,JM, Device and Methods for Detecting the Response of a Plurality of Cells to at Least One Analyte of Interest, US Pat.No. 7,713,733 B2, May 11, 2010   Full Text Link

Baudenbacher,FJ, Wikswo,JP, Balcarcel,RR, Cliffel,D, Eklund,S, Gilligan,JM, McGuinness,O, Monroe,T, Prokop,A, Stremler,MA, Werdich,AA, Apparatus and Methods for Monitoring the Status of a Metabolically Active Cell, US Pat.No. 7,704,745 B2, Apr. 27, 2010   Full Text Link

Wikswo,JP, Baudenbacher,FJ, Haselton,FR, Hofmeister,WH, Lin,CP, McCawley,LJ, Stremler,MA, Weaver,A, Bioreactors With Substance Injection Capacity, US Pat.No. 7,790,443 B2,  Sept. 7, 2010   Full Text Link

Wikswo,JP, Baudenbacher,FJ, Prokop,A, LeBoeuf,EJ, Chung,CY, Cliffel,DE, Haselton,FR, Hofmeister,WH, Lin,CP, McCawley,LJ, Reiserer,RS, Stremler,MA, Capillary Perfused Bioreactors With Multiple Chambers, US, Patent Number - 7,534,601 B2, 2009  Full Text Link

Wikswo,JP, Baudenbacher,FJ, McGuinness,O, Device and Methods for Monitoring the Status of at Least One Cell, US Patent Number - 7,435,578 B2, 2008   Full Text Link  

Conference Proceedings

Uzelac I, Holcomb M, Reiserer RS, Fenton FH, Wikswo JP, High-Power Current Source with Real-Time Arbitrary Waveform for In Vivo and In Vitro Studies of Defibrillation, Computing in Cardiology, 40:667-670, 2013

Chowdhury,S et al. Investigation of Automated Cell Manipulation in Optical Tweezers Assisted Microfluidic Chamber Using Simulation. ASME 5th International Conference on Micro- and Nanosystems, Washington, DC, 2012

Cornforth,TW and Lipson,H. Symbolic Regression of Multiple-Tim-Scale Dynamical Systems. 14th International Conference on Genetic and Evolutionary Computation, Philadelphia, PA, GECCO 12 Proceedings, 735-742, 2012   DOI Link

Ly,DL, Saxena,A, Lipson,H. Co-Evolutionary Predictors for Kinematic Pose Inference Form RGBD Images. 14th International Conference on Genetic and Evolutionary Computation, Philadelphia, PA, GECCO 12 Proceedings, 967-974, 2012   DOI Link

Cornforth,TW, Torresen,J, Lipson,H. Ion Channel Modeling With Analog Circuit Evolution. 13th annual conference companion on Genetic and evolutionary computation, Dublin, Ireland, GECCO 11 Proceedings, 33-34, 2011   DOI Link

Moriguchi H, Lipson H, Learning Symbolic Forward Models for Robotic Motion Planning and Control, European Conference on Artificial Life (ECAL'11), 2011

Ly,DL and Lipson,H. Trainer Selection Strategies for Coevolving Rank Predictors. IEEE Congress on Evolutionary Computation (CEC), Ithaca, NY, 2399-2406, 2011   DOI Link

Ly,DL, Saxena,A, Lipson,H. Pose Estimation From a Single Depth Image for Arbitrary Kinematic Skeletons. RGB-D workshop in robotics:  Science and Systems, USC, 37-38, 2011   Full Text Link

Schmidt,M and Lipson,H. Automated Modeling of Stochastic Reactions With Large Measurement Time-Gaps. 13th annual conference companion on Genetic and evolutionary computation, Dublin, Ireland, GECCO 11 Proceedings, 307-314, 2011   DOI Link

Davis,LM, Canfield,BK, Germann,JA, King,JK, Robinson,WN, Dukes III,AD, Rosenthal,SJ, Samson,PC, Wikswo,JP. Four-Focus Single-Particle Position Determination in a Confocal Microscope. In: Single molecule spectroscopy and imaging III, Proceedings SPIE, Vol. 7571, Enderlein,J and Gryczynski,Z, eds. SPIE, Bellingham,  WA, 757112 2010

Seale,K, Armstrong,P, Wikswo,J. The Systems Biology and Bioengineering Undergraduate Research Experience at Vanderbilt University. Preparing the Engineers and Technologists of Tomorrow, ASEE Southeastern Section Annual Conference, Marietta, GA,, 2009

Faley SL, Copland M, Wlodkowic D, Kolch W, Seale KT, Wikswo JP, Cooper JM, Pachinko Biology: Gambling on Single Cells, 2009 IEEE 39th Annual Northeast Bioengineering Conference, 3-5 April 2009, Boston, MA, pp. 1-3, 2009   doi: 10.1109/NEBC.2009.4967791

Ges,IA and Baudenbacher,FJ. Amperometric Glucose Sensor for Real Time Extracellular Glucose Monitoring in Microfluidic Device. In: Nanotechnology 2008: Technical proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show: Boston, June 1-5, Romanowicz,BF and Laudon,M, eds. Nano Science and Technology Institute; CRC Press, Boston, MA; Boca Raton, FL, USA, 253-256, 2008

Kim,EGR, Sivasubramaniam,P, Wikswo,JP, Seale,KT. Differential Optical Flow for Automated Cell Motility. In: Micro total analysis systems 2008: proceedings of the ?TAS 2008: Twelfth International Conference on Miniaturized Systems for Chemistry and Life Sciences, Locascio,LE, ed. Chemical and Biological Microsystems Society, San Diego, CA, 1831-1833, 2008

Hughey J, Wikswo JP, Seale KT, Intra-Microfluidic Pinocytic Loading of Human T Cells, IEEE/NIH Life Science Systems and Applications Workshop (LISSA), pp. 132-135, 2007

Prokop,A, Prokop,Z, Schaffer,D, Kozlov,E, Wikswo,JP, Cliffel,D, Baudenbacher,F. NanoLiterBioReactor:  Monitoring of Long-Term Mammalian Cell Physiology at Nanofabricated Scale. In: Biological and Bioinspired Materials and Devices, Aizenberg,J, Orme,C, Landis,WJ, Wang,R, eds. MRS,  W9.5/O5.5 2004