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A widespread yet overlooked ribosomal modification in bacteria

Apr. 2, 2026—By Joshua Huang A new study from the Mitchell Lab reveals that even the ribosome, one of the most intensively studied molecular machines in biology, still holds hidden surprises. They have uncovered a previously undetected chemical modification in a key ribosomal protein, uL16, in which a single oxygen atom in the protein backbone is replaced...

Nuclear magnetic resonance‐based fragment screen yields novel E3 ligases for use in PROTAC therapy

Apr. 2, 2026—By Shelby A. Harris PROteolysis TArgeting Chimeras, known as PROTACs, are a recently developed group of therapeutics that utilize the ubiquitin-proteasome system to target and degrade disease associated proteins by recruiting E3 ligase. Of the many different E3 ligases found in human cells, over 600 are known to be expressed and only a few are...

CSB Research Spotlight: Lacy Lab—Novel vaccine protects against C. diff disease and recurrence

Feb. 20, 2026—Clostridioides difficile (C. diff) is the leading cause of health care– and antibiotic–associated infection. It causes diarrhea and colitis (inflammation of the colon) and nearly half a million C. diff infections in the U.S. each year and about 29,000 deaths, resulting in an estimated $4.8 billion in health care costs. People taking antibiotics; those who...

CSB Research Spotlight: Sanders Lab—Promising small molecule may help with sudden cardiac death

Feb. 5, 2026—Long QT syndrome (LQTS) is a hereditary or acquired cardiac disorder that affects the electrical system of the heart, which causes a delay in the heart’s repolarization or reset time. This delay means the heart takes longer to reset between beats. LQTS is a fatal disorder linked to syncope, arrhythmia, and cardiac arrest. Type 1...

Heme Biosynthesis is controlled by reversible feedback mechanism inside the mitochondrial matrix

Jan. 29, 2026—By Shelby A. Harris Heme is vital for life. It is needed for oxygen transport, drug detoxification, and many other biological functions. Regulation is key, too much or too little heme can cause a host of problems in the body. Aminolevulinic acid synthase (ALAS) is heme’s rate-limiting enzyme that functions by the condensation of glycine...

CSB Research Spotlight: Georgiev Lab—Developing antibody therapeutics against existing and emerging viral threats

Jan. 27, 2026—The Georgiev lab recently led a multi-institutional study, published in the journal Cell, that focused on the development of antibody therapeutics against existing and emerging viral threats, including RSV (respiratory syncytial virus) and avian influenza viruses. The study showed that a protein language model could design functional human antibodies that recognized the unique antigen sequencies...

Egli awarded the Richard Armstrong Professorship of Innovation in Biochemistry

Jan. 8, 2026—Martin Egli, professor of biochemistry, has been awarded the Richard Armstrong Professorship of Innovation in Biochemistry. “Martin is an internationally recognized scholar and highly deserving of this honor,” said Biochemistry Department Chair David Cortez. Dr. Egli earned his undergraduate and doctoral degrees in Chemistry from ETH Zurich and completed postdoctoral training at MIT in the...

Mechanistic insights into FX-909: a next-generation PPARγ inverse agonist

Dec. 11, 2025—By Cameron I. Cohen Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor transcription factor which regulates the expression of genes involved in differentiation, metabolism, adipogenesis, and insulin sensitization. PPARγ consists of an N-terminal disordered activation domain (NTD), a central DNA-binding domain (DBD), and a C-terminal ligand-binding domain (LBD). The activation and repression of PPARγ...

Kate Clowes Moster wins the 2026 Dr. Anne Karpay Award in Structural Biology

Nov. 13, 2025—By Karen Davis Congratulations to Kate Clowes Moster, of the Sanders lab, on being named the 2026 recipient of the Dr. Anne Karpay Award in Structural Biology. “I’m really honored to be selected for the Karpay Award,” Clowes Moster said. Kate began her scientific journey in West Virginia, where she grew up fascinated with nature...

A new spin (label) on Alphafold2: DEERfold guides Alphafold2 modeling with DEER distance distributions

Nov. 6, 2025—By Shelby A. Harris No one can argue that the development of AlphaFold2 (AF2) has been one of the greatest achievements in the realm of protein structure prediction. However, AF2 has been plagued by two major limitations: (1) The quality of the predicted models depends on the quality of the multiple sequence alignment (MSA) input...

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