Antonia Kaczkurkin
Assistant Professor of Psychology
Antonia Kaczkurkin is an Assistant Professor in Psychology at Vanderbilt University. She received her Master of Arts and Ph.D. degrees in clinical psychology from the University of Minnesota. She completed her APA-accredited clinical internship at Hennepin County Medical Center in Minneapolis, Minnesota. As a postdoctoral fellow at the University of Pennsylvania, Dr. Kaczkurkin was funded by a National Institute of Mental Health (NIMH) Research Supplement to Promote Diversity in Health-Related Research. Dr. Kaczkurkin is currently funded by a K99/R00 Pathway to Independence Award from the NIMH.
Dr. Kaczkurkin’s research focuses on understanding the neurobiological mechanisms that contribute to the etiology of internalizing disorders. She integrates multimodal measures such as functional magnetic resonance imaging (fMRI), cerebral blood flow, brain anatomy, psychophysiology (e.g., electroencephalography (EEG), startle blink, skin conductance), and behavior to develop a comprehensive understanding of the basic mechanisms underlying anxiety and depressive disorders. Her research aims to:
1) Investigate abnormal brain anatomy and functioning in anxiety and depressive disorders.
2) Understand the neurobiological heterogeneity that exists within internalizing symptoms.
3) Apply our knowledge about these neurobiological differences to improve treatment outcomes.
Representative Publications
50) Kaczkurkin, A. N., Simon, S., Brown, L., & Asnaani, A. (in press). The relationship between cultural self-construal and social anxiety symptom severity in a clinical sample of treatment-seeking patients. Transcultural Psychiatry.
49) Chand, G. B., Singhal, P., Dwyer, D. B., Wen, J., Erus, G., Doshi, J., Srinivasan, D., Mamourian, E., Varol, E., Sotiras, A., Hwang, G., Dazzan, P., Kahn, R. S., Schnack, H. G., Zanetti, M. V., Meisenzahl, E., Busatto, G. F., Crespo-Facorro, B., Pantelis, C., Wood, S. J., Zhuo, C., Shinohara, R. T., Shou, H., Fan, Y., Koutsouleris, N., Kaczkurkin, A. N., Moore, T. M., Verma, A., Calkins, M. E., Gur, R. E., Gur, R. C., Ritchie, M. D., Satterthwaite, T. D., Wolf, D. H., & Davatzikos, C. (in press). Schizophrenia imaging signatures and their associations with cognition, psychopathology, and genetics in the general population. American Journal of Psychiatry.
48) Kaczkurkin, A. N. (2022). Uncovering potential mechanisms of the relationship between structural deficits and general psychopathology. Biological Psychiatry Global Open Science, 2, 2-4. https://doi.org/10.1016/j.bpsgos.2021.11.011
47) Bas-Hoogendam, J. M., Groenewold, N. A., Aghajani, M., Freitag, G. F., Harrewijn, A., Hilbert, K., …Kaczkurkin, A. N., et al. (2022). ENIGMA-anxiety working group: Rationale for and organization of large-scale neuroimaging studies of anxiety disorders. Human Brain Mapping, 43, 83-112. https://doi.org/10.1002/hbm.25100
46) Harrewijn, A., Cardinale, E. M., Groenewold, N. A., Bas-Hoogendam, J. M., Aghajani, M., Hilbert, K., …Kaczkurkin, A. N.… et al. (2021) Cortical and subcortical brain structure in generalized anxiety disorder – findings from 28 research sites in the ENIGMA-Anxiety Working Group. Translational Psychiatry, 11, 1-15. https://doi.org/10.1038/s41398-021-01622-1
45) Kaczkurkin, A. N., Mu, W., Gallagher, T., Lieblich, S., Tyler, J., & Foa, E. B. (2021). The association of obsessive-compulsive disorder, anxiety disorders, and posttraumatic stress disorder with impairment related to eating pathology. Journal of Obsessive-Compulsive and Related Disorders, 31, 1-8. https://doi.org/10.1016/j.jocrd.2021.100685
44) Jeong, H. J., Durham, E. L., Moore, T. M., Dupont, R. M., McDowell, M., Cardenas-Iniguez, C., Micciche, E. T., Berman, M. G., Lahey, B. B., & Kaczkurkin, A. N. (2021). Association between latent trauma and brain structure in children. Translational Psychiatry, 11, 1-9. https://doi.org/10.1038/s41398-021-01357-z
43) Cardenas-Iniguez, C., Moore, T. M., Kaczkurkin, A. N., Meyer, F. A. C., Satterthwaite, T. D., Fair, D. A., White, T., Blok, E., Applegate, B., Thompson, L. M., Rosenberg, M. D., Hedeker, D., Berman, M. G., & Lahey, B. B. (2021). Direct and indirect associations of widespread individual differences in brain white matter microstructure with executive functioning and general and specific dimensions of psychopathology in children. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 1-14. https://doi.org/10.1016/j.bpsc.2020.11.007
42) Zugman, A., Harrewijn, A., Cardinale, E. M., Zwiebel, H., Freitag, G. F… Kaczkurkin, A. N., et al. (2021). Mega-analysis methods in ENIGMA: The experience of the generalized anxiety disorder working group. Human Brain Mapping, 43, 255-277. https://doi.org/10.1002/hbm.25096
41) Berg, H., Ma., Y., Rueter, A., Kaczkurkin, A. N., Burton, P. C., DeYoung, C. G., MacDonald, A. W., Sponheim, S. R., & Lissek, S. M. (2021). Salience and central executive networks track overgeneralization of conditioned fear in post-traumatic stress disorder. Psychological Medicine, 1-10. https://doi.org/10.1017/S0033291720001166
40) Garrett-Ruffin, S., Cowden Hindash, A., Kaczkurkin, A. N., Mears, R. P., Morales, S., Paul, K., Pavlov, Y. G., & Keil, A. (2021). Open science in psychophysiology: An overview of challenges and emerging solutions. Psychophysiology, 162, 69-78. https://doi.org/10.1016/j.ijpsycho.2021.02.005
39) Durham, E. L., Jeong, H. J., Moore, T. M., Dupont, R. M., Cardenas-Iniguez, C., Cui, Z., Stone, F., Berman, M. G., Lahey, B. B., & Kaczkurkin, A. N. (2021). Association of gray matter volumes with general and specific dimensions of psychopathology in children. Neuropsychopharmacology, 46, 1333–1339. https://doi.org/10.1038/s41386-020-00952-w
38) Lahey, B. B., Moore, T. M., Kaczkurkin, A. N., & Zald, D. H. (2021). Hierarchical models of psychopathology: Empirical support, implications, and remaining issues. World Psychiatry, 20, 57-63. https://doi.org/10.1002/wps.20824
37) Baller, E. B., Kaczkurkin, A. N., Sotiras, A., Adebimpe, A., Bassett, D. S., Calkins, M. E., Cui, Z., Gur, R. E., Gur, R. C., Linn, K. A., Moore, T. M., Roalf, D. R., Varol, E., Wolf, D. H., Xia, C. H., Davatzikos, C., & Satterthwaite, T. D. (2021). Neurocognitive and functional heterogeneity in depressed youth. Neuropsychopharmacology, 46, 783-790. https://doi.org/10.1038/s41386-020-00871-w
36) Kaczkurkin, A. N., Tyler, J., Turk-Karan, E., Belli, G., & Asnaani, A. (2021). The association between insomnia and anxiety symptoms in a naturalistic treatment setting. Behavioral Sleep Medicine, 19(1), 110-125. https://doi.org/10.1080/15402002.2020.1714624
35) Moore, T. M., Kaczkurkin, A. N., Durham, E. L., Jeong, H. J., McDowell, M. G., Dupont, R. M., Applegate, B., Tackett, J. L., Cardenas-Iniguez, C., Kardan, O., Akcelik, G. N., Stier, A. J., Rosenberg, M. D., Hedeker, D., Berman, M. G., & Lahey. B. B. (2020). Criterion validity and relationships between alternative hierarchical dimensional models of general and specific psychopathology. Journal of Abnormal Psychology, 129(7), 677-688. https://doi.org/10.1037/abn0000601
34) Kaczkurkin, A. N., Moore, T. M., Sotiras, A., Xia, C. H., Shinohara, R. T., & Satterthwaite, T. D. (2020). Approaches to defining common and dissociable neurobiological deficits associated with psychopathology in youth. Biological Psychiatry, 88, 51-62. https://doi.org/10.1016/j.biopsych.2019.12.015
33) Satterthwaite, T. D., Feczko, E., Kaczkurkin, A. N., & Fair, D. A. (2020). Parsing psychiatric heterogeneity through common and unique circuit-level deficits. Biological Psychiatry, 88, 4-5. https://doi.org/10.1016/j.biopsych.2020.04.012
32) Neufeld, N. H., Kaczkurkin, A. N., Sotiras, A., Mulsant, B. H., Dickie, E. W., Flint, A. J., Meyers, B. S., Alexopoulos, G. S., Rothschild, A. J., Whyte, E. M., Mah, L., Nierenberg, J., Hoptman, M. J., Davatzikos, C., Satterthwaite, T. D., Voineskos, A. N. (2020). Structural brain networks in remitted psychotic depression. Neuropsychopharmacology, 45, 1223-1231. https://doi.org/10.1038/s41386-020-0646-7
31) Asnaani, A., Benhamou, K., Kaczkurkin, A. N., Turk-Karan, E., & Foa., E. B. (2020). Beyond the constraints of an RCT: Naturalistic treatment outcomes for anxiety-related disorders. Behavior Therapy, 51, 434-446. https://doi.org/10.1016/j.beth.2019.07.007
30) Kaczkurkin, A. N. (2020). Advances in mapping the startle eye-blink response onto neural circuits. Biological Psychiatry, 87, E9-E11. https://doi.org/10.1016/j.biopsych.2019.12.019
29) Kaczkurkin, A. N., Sotiras, A., Baller, E. B., Barzilay, R., Calkins, M. E., Chand, G. B., Cui, Z., Erus, G., Fan, Y., Gur, R. E., Gur, R. C., Moore, T. M., Roalf, D. R., Rosen, A. F. G., Ruparel, K., Shinohara, R. T., Varol, E., Wolf, D. H., Davatzikos, C., & Satterthwaite, T. D. (2020). Neurostructural heterogeneity in youths with internalizing symptoms. Biological Psychiatry, 87, 473-482. https://doi.org/10.1016/j.biopsych.2019.09.005
28) Asnaani, A., Kaczkurkin, A. N., Fitzgerald, H. E., Jerud, A., & Foa., E. B. (2020). The association between cognitive coping strategies and treatment outcomes in smokers with PTSD. Psychological Trauma: Theory, Research, Practice, and Policy, 12(1), 92-100. https://doi.org/10.1037/tra0000473
27) Hammell, A. E., Helwig, N. E., Kaczkurkin, A. N., Sponheim, S. R., & Lissek S. M. (2020). The temporal course of over-generalized conditioned threat expectancies in posttraumatic stress disorder. Behaviour Research and Therapy, 124, 1-9. https://doi.org/10.1016/j.brat.2019.103513
26) Jirsaraie, R. J., Kaczkurkin, A. N., Rush, S., Piiwia, K., Adebimpe, A., Bassett, D. S., Bourque, J., Calkins, M. E., Cieslak, M., Ciric, R., Cook, P. A., Davila, D., Elliott, M. A., Leibenluft, E., Murtha, K., Roalf, D. R., Rosen, A. F. G., Ruparel, K., Shinohara, R. T., Sotiras, A., Wolf, D. H., Davatzikos, C., & Satterthwaite, T. D. (2019). Accelerated cortical thinning within structural brain networks is associated with irritability in youth. Neuropsychopharmacology, 44, 2254-2262. https://doi.org/10.1038/s41386-019-0508-3
25) Kaczkurkin, A. N.,† Park, S. S.,† Sotiras, A., Moore, T. M., Calkins, M. E., Cieslak, M., Rosen, A. F. G., Ciric, R., Xia, C. H., Cui, Z., Sharma, A., Wolf, D. H., Ruparel, K., Pine, D. S., Shinohara, R. T., Roalf, D. R., Gur, R. C., Davatzikos, C., Gur, R. E., & Satterthwaite, T. D. (2019). Evidence for dissociable linkage of dimensions of psychopathology to brain structure in youths. American Journal of Psychiatry, 176, 1000-1009. https://doi.org/10.1176/appi.ajp.2019.18070835
†Denotes equal contribution and first authorship
24) Nassar,† R., Kaczkurkin,† A. N., Xia, C. H., Sotiras, A., Pehlivanova, M., Moore, T. M., Garcia de La Garza, A., Roalf, D. R., Rosen, A. F. G., Lorch, S. A., Ruparel, K., Shinohara, R. T., Davatzikos, C., Gur, R. C., Gur, R. E., & Satterthwaite, T. D. (2019). Gestational age is dimensionally associated with structural brain network abnormalities across development. Cerebral Cortex, 29, 2102-2114. https://doi.org/10.1093/cercor/bhy091
†Denotes equal contribution and first authorship
23) Kaczkurkin, A. N., Raznahan, A., & Satterthwaite, T. D. (2019). Sex differences in the developing brain: Insights from multimodal neuroimaging. Neuropsychopharmacology, 44, 71-85. https://doi.org/10.1038/s41386-018-0111-z
22) Zang, Y., Gay, N. G., Kaczkurkin, A. N., McLean, C. P., Schuster Wachen, J., Yarvis, J. S., Litz, B. T., Yadin, E., Mintz, J., Roache, J. D., Young-McCaughan, S., Peterson, A. L., Foa, E. B., & Resick, P. A., for the STRONG STAR Consortium. (2018). Factor structure and psychometric properties of the peritraumatic and posttraumatic emotions questionnaires among active duty military personnel with posttraumatic stress disorder. Journal of Traumatic Stress, 31, 826-836. https://doi.org/10.1002/jts.22350
21) Kaczkurkin, A. N., Fitzgerald, H., Tyler, J., & Asnaani, A. (2018). The contribution of anxiety sensitivity to obsessive-compulsive and anxiety symptoms in a naturalistic treatment setting. Cognitive Therapy and Research, 42, 661-673. https://doi.org/10.1007/s10608-018-9909-6
20) Kaczkurkin, A. N., Moore, T. M., Calkins, M. E., Ciric, R., Detre, J. A., Elliott, M. A., Foa, E. B., Garcia de La Garza, A., Roalf, D. R., Rosen, A., Ruparel, K., Shinohara, R. T., Xia, C. H., Wolf, D. H., Gur, R. E., Gur, R. C., & Satterthwaite, T. D. (2018). Common and dissociable regional cerebral blood flow differences associate with dimensions of psychopathology across categorical diagnoses. Molecular Psychiatry, 23, 1981-1989. http://dx.doi.org/10.1038/mp.2017.174
19) Xia, C. H., Ma, Z., Ciric, R., Gu, S., Betzel, R. F., Kaczkurkin, A. N., Calkins, M. E., Cook, P. A., Garcia de la Garza, A., Vandekar, S. N., Moore, T. M., Roalf, D. R., Ruparel, K., Wolf, D. H., Davatzikos, C., Gur, R. C., Gur, R. E., Shinohara, R. T., Bassett, D. S., & Satterthwaite, T. D. (2018). Linked dimensions of psychopathology and connectivity in functional brain networks. Nature Communications, 9(3003), 1-14. https://doi.org/10.1038/s41467-018-05317-y
18) Chang, C., Kaczkurkin, A. N., McLean, C. P., & Foa, E. B. (2018). Emotion regulation is associated with PTSD and depression among female adolescent survivors of childhood sexual abuse. Psychological Trauma: Theory, Research, Practice, and Policy, 10(3), 319-326. http://dx.doi.org/10.1037/tra0000306
17) Asnaani, A., Kaczkurkin, A. N., Benhamou, K., Yarvis, J. S., Peterson, A. L., Young-McCaughan, S., Borah, E. V., Dondanville, K. A., Hembree, E. A., Litz, B. T., Mintz, J., & Foa, E. B, for the STRONG STAR Consortium. (2018). The influence of posttraumatic stress disorder on health functioning in active-duty military service members. Journal of Traumatic Stress, 31, 307-316. http://dx.doi.org/10.1002/jts.22274
16) Pehlivanova, M., Wolf, D. H., Sotiras, A., Kaczkurkin, A. N., Moore, T. M., Ciric, R., Cook, P. A., Garcia de La Garza, A., Rosen, A. F. G., Ruparel, K., Sharma, A., Shinohara, R. T., Roalf, D. R., Gur, R. C., Davatzikos, C., Gur, R. E., Kable,^ J. W., & Satterthwaite,^ T. D. (2018). Diminished cortical thickness is associated with impulsive choice in adolescence. The Journal of Neuroscience, 38(10), 2471-2481. https://doi.org/10.1523/JNEUROSCI.2200-17.2018
^ Denotes shared last authorship
15) Hall-Clark, B. N., Kaczkurkin, A. N., Asnaani, A., Zhong, J., Peterson, A. L., Yarvis, J. S., Borah, E. V., Dondanville, K. A., Hembree, E. A., Litz, B. T. Mintz, J., Young-McCaughan, S. & Foa, E. B (2017). Ethnoracial differences in PTSD symptoms and trauma-related cognitions in treatment-seeking active-duty military personnel with PTSD. Psychological Trauma: Theory, Research, Practice, and Policy, 9, 741-745. http://dx.doi.org/10.1037/tra0000242
14) Kaczkurkin, A. N., Zang, Y., Gay, N. G., Peterson, A. L., Yarvis, J. S., Borah, E. V., Dondanville, K. A., Hembree, E. A., Litz, B. T., Mintz, J., Young-McCaughan, S., & Foa, E. B; for the STRONG STAR Consortium. (2017). Cognitive emotion regulation strategies associated with the DSM-5 posttraumatic stress disorder criteria. Journal of Traumatic Stress, 30, 343-350. http://dx.doi.org/10.1002/jts.22202
13) Asnaani, A., Kaczkurkin, A. N., Alpert, E., McLean, C. P., Simpson, H. B., & Foa, E. B. (2017). The effect of treatment on quality of life and functioning in OCD. Comprehensive Psychiatry, 73, 7-14. http://dx.doi.org/10.1016/j.comppsych.2016.10.004
12) Kaczkurkin, A.N., Burton, P. C., Chazin, S. M., Manbeck, A. B., Espensen-Sturges, T., Cooper, S. E., Sponheim, S. R., & Lissek, S. (2017). Neural substrates of overgeneralized conditioned fear in PTSD. American Journal of Psychiatry, 174, 125-134. http://dx.doi.org/10.1176/appi.ajp.2016.15121549
11) Zandberg, L., Kaczkurkin, A. N., McLean, C. P., Rescorla, L., Yadin, E., & Foa, E. B. (2016). Treatment of adolescent PTSD: The impact of prolonged exposure versus client centered therapy on co-occurring emotional and behavioral problems. Journal of Traumatic Stress, 29, 507-514. http://dx.doi.org/10.1002/jts.22138
10) Kaczkurkin, A. N., Moore, T. M., Ruparel, K., Ciric, R., Calkins, M. E., Shinohara, R. T., Elliott, M. A., Hopson, R., Roalf, D. R., Vandekar, S. N., Gennatas, E. D., Wolf, D. H., Scott, J. C., Pine, D. S., Leibenluft, E., Detre, J. A., Foa, E. B., Gur, R. E., Gur, R. C., & Satterthwaite, T. D. (2016). Elevated amygdala perfusion mediates developmental sex differences in trait anxiety. Biological Psychiatry, 80, 775-785. http://dx.doi.org/10.1016/j.biopsych.2016.04.021
9) Kaczkurkin, A. N., Asnaani, A., Hall-Clark, B., Peterson, A. L., Yarvis, J. S., & Foa, E. B.; for the STRONG STAR Consortium. (2016). Ethnic and racial differences in clinically relevant symptoms in active duty military personnel with posttraumatic stress disorder. Journal of Anxiety Disorders, 43, 90-98. http://dx.doi.org/10.1016/j.janxdis.2016.09.004
8) Kaczkurkin, A. N., Asnaani, A., Zhong, J., & Foa, E. B. (2016). The moderating effect of state anger on treatment outcome in female adolescents with PTSD. Journal of Traumatic Stress, 29, 325-331. http://dx.doi.org/10.1002/jts.22116
7) Kaczkurkin, A. N., Asnaani, A., Alpert, E., & Foa, E. B. (2016). The impact of treatment condition and the lagged effects of PTSD symptom severity and alcohol use on changes in alcohol craving. Behaviour Research and Therapy, 79, 7-14. http://dx.doi.org/10.1016/j.brat.2016.02.001
6) Asnaani, A., Kaczkurkin, A. N., Tannahill, H., & Fitzgerald, H. (2016). Moderators of change in social anxiety during CBT in a transdiagnostic, naturalistic treatment-seeking sample. Journal of Experimental Psychopathology, 7, 655-670. http://dx.doi.org/10.5127/jep.055416
5) Kaczkurkin, A. N., & Foa, E. B. (2015). Cognitive-behavioral therapy for anxiety disorders: An update on the empirical evidence. Dialogues in Clinical Neuroscience, 17, 337-346. http://dx.doi.org/10.31887/DCNS.2015.17.3/akaczkurkin
4) Lissek, S., Kaczkurkin, A. N., Rabin, S., Geraci, M., Pine, D. S., & Grillon, C. (2014). Generalized anxiety disorder is associated with overgeneralization of classically conditioned fear. Biological Psychiatry, 75, 909-915. http://dx.doi.org/10.1016/j.biopsych.2013.07.025
3) Kaczkurkin, A. N. (2013). The effect of manipulating task difficulty on error-related negativity in individuals with obsessive-compulsive symptoms. Biological Psychology, 93, 122-131. http://dx.doi.org/10.1016/j.biopsycho.2013.01.001
2) Kaczkurkin, A. N., & Lissek, S. M. (2013). Generalization of conditioned fear and obsessive-compulsive traits. Journal of Psychology and Psychotherapy: Cognitive and Experimental Psychology, S7(003), 1-7.
1) Scheres, A., Tontsch, C., Thoeny, A. L., & Kaczkurkin, A. (2010). Temporal reward discounting in Attention-Deficit/Hyperactivity Disorder: The contribution of symptom domains, reward magnitude, and session length. Biological Psychiatry, 67, 641-648. http://dx.doi.org/10.1016/j.biopsych.2009.10.033
Honors
2022 APS Janet Taylor Spence Award, Association for Psychological Science (APS)
2021 Junior Faculty Teaching Fellowship, Center for Teaching, Vanderbilt University
2020 Sloan Research Fellow, Alfred P. Sloan Foundation
2020 APS Rising Star, Association for Psychological Science (APS)
2020 Alies Muskin Career Development Leadership Program (CDLP) Awardee, Anxiety and Depression Association of America (ADAA)
2019 Society of Biological Psychiatry Domestic Travel Fellowship Award, SoBP
2018-2022 NIMH K99/R00 Pathway to Independence Award (PI; grant number R00MH117274)
2018-2019 Career Development Institute Awardee, Career Development Institute for Psychiatry, University of Pittsburgh