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Antonia Kaczkurkin

Assistant Professor of Psychology

Antonia Kaczkurkin is an Assistant Professor in Psychology at Vanderbilt University. She received her Master of Arts and Ph.D. degrees in clinical psychology from the University of Minnesota. She completed her APA-accredited clinical internship at Hennepin County Medical Center in Minneapolis, Minnesota. As a postdoctoral fellow at the University of Pennsylvania, Dr. Kaczkurkin was funded by a National Institute of Mental Health (NIMH) Research Supplement to Promote Diversity in Health-Related Research. Dr. Kaczkurkin is currently funded by a K99/R00 Pathway to Independence Award from the NIMH.

Dr. Kaczkurkin’s research focuses on understanding the neurobiological mechanisms that contribute to the etiology of internalizing disorders. She integrates multimodal measures such as functional magnetic resonance imaging (fMRI), cerebral blood flow, brain anatomy, psychophysiology (e.g., electroencephalography (EEG), startle blink, skin conductance), and behavior to develop a comprehensive understanding of the basic mechanisms underlying anxiety and depressive disorders. Her research aims to:

1) Investigate abnormal brain anatomy and functioning in anxiety and depressive disorders.

2) Understand the neurobiological heterogeneity that exists within internalizing symptoms.

3) Apply our knowledge about these neurobiological differences to improve treatment outcomes.

 

Representative Publications

39) Zugman, A., Harrewijn, A., Cardinale, E. M., Zwiebel, H., Freitag, G. F… Kaczkurkin, A. N., et al. (in press). Mega-analysis methods in ENIGMA: The experience of the Generalized Anxiety Disorder Working Group. Human Brain Mapping. https://doi.org/10.1002/hbm.25096

 

38) Moore, T. M., Kaczkurkin, A. N., Durham, E. L., Jeong, H. J., McDowell, M. G., Dupont, R. M., Applegate, B., Tackett, J. L., Cardenas-Iniguez, C., Kardan, O., Akcelik, G. N., Stier, A. J., Rosenberg, M. D., Hedeker, D., Berman, M. G., & Lahey. B. B. (in press). Criterion validity and relationships between alternative hierarchical dimensional models of general and specific psychopathology. Journal of Abnormal Psychology.

 

37) Kaczkurkin, A. N., Tyler, J., Turk-Karan, E., Belli, G., & Asnaani, A. (in press). The association between insomnia and anxiety symptoms in a naturalistic treatment setting. Behavioral Sleep Medicine. https://doi.org/10.1080/15402002.2020.1714624

 

36) Berg, H., Ma., Y., Rueter, A., Kaczkurkin, A. N., Burton, P. C., DeYoung., C. G., MacDonald, A. W., Sponheim, S., & Lissek, S. (in press). Salience and central executive networks track overgeneralization of conditioned fear in post-traumatic stress disorder. Psychological Medicine. https://doi.org/10.1017/S0033291720001166

 

35) Lahey, B. B., Moore, T. M., Kaczkurkin, A. N., & Zald, D. H. (in press). Hierarchical models of psychopathology: empirical support, implications, and remaining issues. World Psychiatry.

 

34) Kaczkurkin, A. N., Moore, T. M., Sotiras, A., Xia, C. H., Shinohara, R. T., & Satterthwaite, T. D. (2020). Approaches to defining common and dissociable neurobiological deficits associated with psychopathology in youth. Biological Psychiatry, 88(1), 51-62. https://doi.org/10.1016/j.biopsych.2019.12.015

 

33) Satterthwaite, T. D., Feczko, E., Kaczkurkin, A. N., & Fair, D. A. (2020). Parsing psychiatric heterogeneity through common and unique circuit-level deficits. Biological Psychiatry, 88(1), 4-5. https://doi.org/10.1016/j.biopsych.2020.04.012

 

32) Neufeld, N. H., Kaczkurkin, A. N., Sotiras, A., Mulsant, B. H., Dickie, E. W., Flint, A. J., Meyers, B. S., Alexopoulos, G. S., Rothschild, A. J., Whyte, E. M., Mah, L., Nierenberg, J., Hoptman, M. J., Davatzikos, C., Satterthwaite, T. D., Voineskos, A. N. (2020). Structural brain networks in remitted psychotic depression. Neuropsychopharmacology, 45(7), 1223-1231. https://doi.org/10.1038/s41386-020-0646-7

 

31) Asnaani, A., Benhamou, K., Kaczkurkin, A. N., Turk-Karan, E., & Foa., E. B. (2020). Beyond the constraints of an RCT: Naturalistic treatment outcomes for anxiety-related disorders. Behavior Therapy, 51(3), 434-446. https://doi.org/10.1016/j.beth.2019.07.007

 

30) Kaczkurkin, A. N. (2020). Advances in mapping the startle eye-blink response onto neural circuits. Biological Psychiatry, 87(6), E9-E11. https://doi.org/10.1016/j.biopsych.2019.12.019

 

29) Kaczkurkin, A. N., Sotiras, A., Baller, E. B., Calkins, M. E., Chand, G. B., Cui, Z., Erus, G., Fan, Y., Gur, R. E., Gur, R. C., Moore, T. M., Roalf, D. R., Rosen, A. F. G., Ruparel, K., Shinohara, R. T., Varol, E., Wolf, D. H., Davatzikos, C., & Satterthwaite, T. D. (2020). Neurostructural heterogeneity in youth with internalizing symptoms. Biological Psychiatry, 87(5), 473-482. https://doi.org/10.1016/j.biopsych.2019.09.005

 

28) Asnaani, A., Kaczkurkin, A. N., Fitzgerald, H., Jerud, A., & Foa., E. B. (2020). The association between cognitive coping strategies and treatment outcomes in smokers with PTSD. Psychological Trauma: Theory, Research, Practice, and Policy, 12(1), 92-100. https://doi.org/10.1037/tra0000473

 

27) Hammell, A. E., Helwig, N. E., Kaczkurkin, A. N., Sponheim, S. R., & Lissek S. M. (2020). The temporal course of over-generalized conditioned threat expectancies in posttraumatic stress disorder. Behaviour Research and Therapy, 124, 103513. https://doi.org/10.1016/j.brat.2019.103513

 

26) Jirsaraie, R. J., Kaczkurkin, A. N., Rush, S., Piiwia, K., Adebimpe, A., Bassett, D. S., Bourque, J., Calkins, M. E., Cieslak, M., Ciric, R., Cook, P. A., Davila, D., Elliott, M. A., Leibenluft, E., Murtha, K., Roalf, D. R., Rosen, A. F. G., Ruparel, K., Shinohara, R. T., Sotiras, A., Wolf, D. H., Davatzikos, C., & Satterthwaite, T. D. (2019). Accelerated cortical thinning within structural brain networks is associated with irritability in youth. Neuropsychopharmacology, 44(13), 2254-2262. https://doi.org/10.1038/s41386-019-0508-3

 

25) Kaczkurkin, A. N.,† Park, S. S.,† Sotiras, A., Moore, T. M., Calkins, M. E., Cieslak, M., Rosen, A. F. G., Ciric, R., Xia, C. H., Cui, Z., Sharma, A., Wolf, D. H., Ruparel, K., Pine, D. S., Shinohara, R. T., Roalf, D. R., Gur, R. C., Davatzikos, C., Gur, R. E., & Satterthwaite, T. D. (2019). Evidence for dissociable linkage of dimensions of psychopathology to brain structure in youths. American Journal of Psychiatry, 176(12), 1000-1009. https://doi.org/10.1176/appi.ajp.2019.18070835 †Denotes equal contribution and first authorship

 

24) Nassar,† R., Kaczkurkin, A. N., Xia, C., Sotiras, A., Pehlivanova, M., Moore, T. M., Garcia de La Garza, A., Roalf, D. R., Rosen, A., Lorch, S., Ruparel, K., Shinohara, R. T., Davatzikos, C., Gur, R. C., Gur, R. E., & Satterthwaite, T. D. (2019). Gestational age is dimensionally associated with structural brain network abnormalities across development. Cerebral Cortex, 29(5), 2102-2114. https://doi.org/10.1093/cercor/bhy091 †Denotes equal contribution and first authorship

 

23) Kaczkurkin, A. N., Raznahan, A., & Satterthwaite, T. D. (2019). Sex differences in the developing brain: Insights from multimodal neuroimaging. Neuropsychopharmacological Reviews, 44, 71-85. https://doi.org/10.1038/s41386-018-0111-z

 

22) Zang, Y., Gay, N., Kaczkurkin, A. N., McLean, C. P., Schuster Wachen, J., Yarvis, J. S., Foa, E. B., & Resick, P. A., for the STRONG STAR Consortium. (2018). Factor structures and psychometric properties of the peritraumatic and posttraumatic emotions questionnaires among active duty military personnel with posttraumatic stress disorder. Journal of Traumatic Stress, 31, 826-836. https://doi.org/10.1002/jts.22350

 

21) Kaczkurkin, A. N., Moore, T. M., Calkins, M. E., Ciric, R., Detre, J. A., Elliott, M. A., Foa, E. B., Garcia de La Garza, A., Roalf, D. R., Rosen, A., Ruparel, K., Shinohara, R. T., Xia, C. H., Wolf, D. H., Gur, R. E., Gur, R. C., & Satterthwaite, T. D. (2018). Common and dissociable regional cerebral blood flow differences associate with dimensions of psychopathology across categorical diagnoses. Molecular Psychiatry, 23(10), 1981-1989. http://dx.doi.org/10.1038/mp.2017.174

 

20) Xia, C. H., Ma, Z., Ciric, R., Gu, S., Betzel, R. F., Kaczkurkin, A. N., Calkins, M. E., Cook, P. A., Garcia de la Garza, A., Vandekar, S., Moore, T. M., Roalf, D. R., Ruparel, K., Wolf, D. H., Davatzikos, C., Gur, R. C., Gur, R. E., Shinohara, R. T., Bassett, D. S., & Satterthwaite, T. D. (2018). Linked dimensions of psychopathology and connectivity in functional brain networks. Nature Communications, 9(3003), 1-14. https://doi.org/10.1038/s41467-018-05317-y †Denotes shared first authorship and equal contribution

 

19) Chang, C., Kaczkurkin, A. N., McLean, C. P., & Foa, E. B. (2018). Emotion regulation is associated with PTSD and depression among female adolescent survivors of childhood sexual abuse. Psychological Trauma, 10, 319-326. http://dx.doi.org/10.1037/tra0000306

 

18) Asnaani, A., Kaczkurkin, A. N., Benhamou, K., Yarvis, J. S., Peterson, A. L., Young-McCaughan, S., & Foa, E. B, for the STRONG STAR Consortium. (2018). The influence of posttraumatic stress disorder on health functioning in active duty military service members. Journal of Traumatic Stress, 31, 307-316. http://dx.doi.org/10.1002/jts.22274

 

17) Pehlivanova, M., Wolf, D. H., Sotiras, A., Kaczkurkin, A. N., Moore, T. M., Ciric, R., Cook, P. A., Garcia de La Garza, A., Rosen, A., Ruparel, K., Sharma, A., Shinohara, R. T., Roalf, D. R., Gur, R. C., Davatzikos, C., Gur, R. E., Kable,^ J. W., & Satterthwaite,^ T. D. (2018). Diminished cortical thickness is associated with impulsive choice in adolescence. Journal of Neuroscience, 38(10), 2471-2481. https://doi.org/10.1523/JNEUROSCI.2200-17.2018 ^ Denotes shared last authorship

 

16) Kaczkurkin, A. N., Fitzgerald, H., Tyler, J., & Asnaani, A. (2018). The contribution of anxiety sensitivity to obsessive-compulsive and anxiety symptoms in a naturalistic treatment setting. Cognitive Therapy and Research, 42, 661-673. https://doi.org/10.1007/s10608-018-9909-6

 

15) Hall-Clark, B., Kaczkurkin, A. N., Asnaani, A., Zhong, J., Peterson, A. L., Yarvis, J. S., Borah, E.V., Dondanville, K.A., Hembree, E. A., Litz, B. T. Mintz, J., Young-McCaughan, S. & Foa, E. B (2017). Ethnoracial differences in PTSD symptoms and trauma-related cognitions in treatment-seeking active duty military personnel with PTSD. Psychological Trauma: Theory, Research, Practice, and Policy, 9, 741-745. http://dx.doi.org/10.1037/tra0000242

 

14) Kaczkurkin, A. N., Zang, Y., Gay, N. G., Peterson, A. L., Yarvis, J. S., Borah, E. V., Dondanville, K. A., Hembree, E. A., Litz, B. T., Mintz, J., Young-McCaughan, S., & Foa, E. B; for the STRONG STAR Consortium. (2017). Cognitive emotion regulation strategies associated with the DSM-5 posttraumatic stress disorder criteria. Journal of Traumatic Stress, 30, 343-350. http://dx.doi.org/10.1002/jts.22202

 

13) Asnaani, A., Kaczkurkin, A. N., Alpert, E., McLean, C. P., Simpson, H. B., & Foa, E. B. (2017). The effect of treatment on quality of life and functioning in OCD. Comprehensive Psychiatry, 73, 7-14. http://dx.doi.org/10.1016/j.comppsych.2016.10.004

 

12) Kaczkurkin, A.N., Burton, P.C., Chazin, S.M., Manbeck, A.B., Espensen-Sturges, T., Cooper, S.E., Sponheim, S.R., & Lissek, S. (2017). Neural substrates of overgeneralized conditioned fear in PTSD. American Journal of Psychiatry, 174, 125-134. http://dx.doi.org/10.1176/appi.ajp.2016.15121549

 

11) Zandberg, L., Kaczkurkin, A. N., McLean, C. P., Rescorla, L., Yadin, E., & Foa, E. B. (2016). Treatment of adolescent PTSD: The impact of prolonged exposure versus client centered therapy on co-occurring emotional and behavioral problems. Journal of Traumatic Stress, 29, 507-514. http://dx.doi.org/10.1002/jts.22138

 

10) Kaczkurkin, A. N., Moore, T. M., Ruparel, K., Ciric, R., Calkins, M. E., Shinohara, R. T., Elliott, M. A., Hopson, R., Roalf, D.R., Vandekar, S. N., Gennatas, E. D., Wolf, D. H., Scott, J. C., Pine, D. S., Leibenluft, E., Detre, J. A., Foa, E. B., Gur, R. E., Gur, R. C., & Satterthwaite, T. D. (2016). Elevated amygdala perfusion mediates developmental sex differences in trait anxiety. Biological Psychiatry, 80, 775-785. http://dx.doi.org/10.1016/j.biopsych.2016.04.021

 

9) Kaczkurkin, A. N., Asnaani, A., Hall-Clark, B., Peterson, A. L., Yarvis, J. S., Foa, E. B., & the STRONG STAR Consortium. (2016). Ethnic and racial differences in clinically relevant symptoms in active duty military personnel with posttraumatic stress disorder. Journal of Anxiety Disorders, 43, 90-98. http://dx.doi.org/10.1016/j.janxdis.2016.09.004

 

8) Kaczkurkin, A. N., Asnaani, A., Zhong, J., & Foa, E. B. (2016). The moderating effect of state anger on treatment outcome in female adolescents with PTSD. Journal of Traumatic Stress, 29, 325-331. http://dx.doi.org/10.1002/jts.22116

 

7) Kaczkurkin, A. N., Asnaani, A., Alpert, E., & Foa, E. B. (2016). The impact of treatment condition and the lagged effects of PTSD symptom severity and alcohol use on changes in alcohol craving. Behaviour Research and Therapy, 79, 7-14. http://dx.doi.org/10.1016/j.brat.2016.02.001

 

6) Asnaani, A., Kaczkurkin, A.N., Tannahill, H., & Fitzgerald, H. (2016). Moderators of change in social anxiety during CBT in a transdiagnostic, naturalistic treatment-seeking sample. Journal of Experimental Psychopathology, 7, 655-670. http://dx.doi.org/10.5127/jep.055416

 

5) Kaczkurkin, A. N., & Foa, E. B. (2015). Cognitive-behavioral therapy for anxiety disorders: an update on the empirical evidence. Dialogues in Clinical Neuroscience, 17(3), 337-346.

 

4) Lissek, S., Kaczkurkin, A. N., Rabin, S., Geraci, M., Pine, D. S., & Grillon, C. (2014). Generalized anxiety disorder is associated with overgeneralization of classically conditioned-fear. Biological Psychiatry, 75(11), 909-915. http://dx.doi.org/10.1016/j.biopsych.2013.07.025

 

3) Kaczkurkin, A. N. (2013). The effect of manipulating task difficulty on error-related negativity in individuals with obsessive-compulsive symptoms. Biological Psychology, 93, 122-131. http://dx.doi.org/10.1016/j.biopsycho.2013.01.001

 

2) Kaczkurkin, A. N., & Lissek, S. M. (2014). Generalization of conditioned fear and obsessive-compulsive traits. Journal of Psychology and Psychotherapy: Cognitive and Experimental Psychology, S7(003), 1-7.

 

1) Scheres, A., Tontsch, C., Thoeny, A. L., & Kaczkurkin, A. (2010). Temporal reward discounting in Attention-Deficit/Hyperactivity Disorder: The contribution of symptom domains, reward magnitude, and session length. Biological Psychiatry, 67, 641-648. http://dx.doi.org/10.1016/j.biopsych.2009.10.033


Honors

2020  Sloan Research Fellow, Alfred P. Sloan Foundation

2020  APS Rising Star, Association for Psychological Science (APS)

2020  Alies Muskin Career Development Leadership Program (CDLP) Awardee, Anxiety and Depression Association of America (ADAA)

2019  Society of Biological Psychiatry Domestic Travel Fellowship Award, SoBP

2018-2022  NIMH K99/R00 Pathway to Independence Award (PI; grant number R00MH117274)

2018-2019  Career Development Institute Awardee, Career Development Institute for Psychiatry, University of Pittsburgh

2017-2018  NIH Research Supplement to Promote Diversity in Health-Related Research, Brain Behavior Laboratory, Perelman School of Medicine, University of Pennsylvania

2017-2019  Distinguished Young Scientists in the Field of Neuropsychopharmacology Travel Award Program, American College of Neuropsychopharmacology

2017  Outstanding Poster Award, Penn Promotes Retreat 2017: Sex Differences and the Microbiome, University of Pennsylvania

2017  Merit Abstract Award for Top-Ranking Submissions, Organization for Human Brain Mapping

2014-2017  Postdoctoral Fellowship for Academic Diversity, University of Pennsylvania