Dr. Shepherd is an international thought-leader in HIV/AIDS research, particularly on the use of statistical methods and large multinational databases to advance treatment. He is heavily involved with research enterprises across three continents (Africa, North America, and South America) and sought-after globally as a reviewer and speaker. As disseminated through 260+ peer-reviewed papers, over 60 invited talks, and more than three dozen workshops, Dr. Shepherd’s work has included pioneering methods in causal inference, ordinal / rank-based data analysis, and two-phase sampling / measurement error. Dr. Shepherd's research has raised the quality of the design and analysis of observational studies and clinical trials across multiple subject domains. Dr. Shepherd's research has been funded by multiple R01s, a PCORI award, and the highly selective R37 MERIT award. A seasoned principal investigator and administrator, Dr. Shepherd has long provided invaluable guidance to collaborators in occupying key roles such as Director of the Data Sciences Core at the Tennessee Center for AIDS Research, Statistical Lead for the Latin American IeDEA cohort, and Methodology Committee Chair for the North American IeDEA cohort. Dr. Shepherd also co-directs the Vanderbilt-Nigeria Biostatistics Training Program and has worked with many graduate students and international trainees. His efforts to expand statistical options for biomedical researchers and improve the application of such options have led to accolades such as his being named a Shayle Searle Fellow (New Zealand, 2016) and American Statistical Association Fellow (United States, 2017).