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Angela L. Jefferson, PhD

Director, Vanderbilt Memory & Alzheimer
Professor of Neurology, Psychology, & Psychiatry

Dr. Angela L. Jefferson is Professor of Neurology at Vanderbilt University, Director of the Vanderbilt Memory & Alzheimer’s Center (, and a clinical neuropsychologist with over 15 years of experience studying risk factors associated with unhealthy cognitive aging, including mild cognitive impairment and Alzheimer’s disease. Dr. Jefferson’s research program focuses on understanding relations between cardiovascular and cerebrovascular health, including hemodynamics, and the pathogenesis and clinical manifestation of Alzheimer’s disease and related disorders. Her research activities are based on three specific areas (1) cardiac function and brain aging, (2) alterations in vascular biology and brain aging, and (3) cerebrovascular changes, white matter degradation, and brain aging. The primary focus of Dr. Jefferson’s research program examines relations between cardiac function and blood flow to the brain and the impact of subclinical cardiac dysfunction on brain aging and Alzheimer’s disease pathophysiology. Dr. Jefferson’s clinical interests include general medical neuropsychology and geriatric neuropsychology with expertise in differentiating mild cognitive impairment and early Alzheimer’s disease from normal cognitive aging. For more information, please visit the Vanderbilt Memory & Alzheimer’s Center website at

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