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Cores Facilities

VU Cores:

The Advanced Computing Center for Research and Education is comprised of High Performance Computing services that provide an environment for a wide variety of research projects across Vanderbilt. These services include: High Performance Computing *** Non-cluster Tape Backup Services Logistical Storage (L-Store) The Research and Education Data Depot Network (REDDnet)

Associate Director: Patrick Bembry
E-Mail:patrick.bembry@Vanderbilt.Edu

Website: http://www.accre.vanderbilt.edu/

The principal mission of the Biomolecular NMR Center is to provide instrumentation for, and aid in obtaining data on the structure and dynamics of biological macromolecules. The Facility offers state-of-the-art instrumentation, training, software and assistance in designing experiments. We strive to help the Vanderbilt community realize the potential of biomolecular NMR and to work with NMR spectroscopists to stay current with the most recent experimental approaches.


Director: Markus Voehler
E-Mail: m.voehler@vanderbilt.edu

Website: http://structbio.vanderbilt.edu/nmr/user_info/userInfo.php

The BRET Office of Postdoctoral Affairs (OPA) assists postdoctoral fellows during their training at Vanderbilt University Medical Center (VUMC). Our office makes postdoctoral appointments and reappointments. We meet with postdoctoral candidates upon faculty request and with new postdoctoral fellows focusing on the Compact Between Postdoctoral Appointees and their MentorsIndividual Development Plan and resources available, including resources to aid postdocs in developing writing and presentation skills.  The BRET Office of Postdoctoral Affairs sponsors the Vanderbilt Postdoctoral Association which welcomes all Vanderbilt postdoctoral fellows from all schools to PDA events such as;the PDA and Shared Resources Poster Symposium and Research Day, monthly meetings, holiday events and celebration ofNational Postdoc Appreciation Weekwith the Postdoc Family Picnic. The Scientist'sannual survey has consistently ranked Vanderbilt as one of the best places for postdocs to work in the United States. Whether you are a prospective postdoctoral fellow considering a move to Nashville or a current postdoctoral fellow seeking assistance, we are here to offer our support.

Core Manager: Karen Perry
E-Mail: karen.perry@vanderbilt.edu

Website:  https://medschool.vanderbilt.edu/postdoc/

The Cancer & Immunology Core (CIC) provides access to mass cytometry and other advanced cytometry services for cancer and immunology research. The CIC uses well-established reagent sets and protocols to help researchers get a first mass cytometry figure or to carry out studies in areas where the technology development has been robust, such as monitoring human T cell subsets.

Core Manager:  Caroline Roe
E-Mail: caroline.e.roe@vanderbilt.edu

Scientific Director:  Jonathan Irish, Ph.D.
E-Mail: jonathan.irish@vanderbilt.edu

Website:  https://my.vanderbilt.edu/cancerimmunology/

The Department of Cell and Development BIology maintains this large and diverse set of instruments located throughout MRB3 and MCN. Equipment is pay/per use and available for anyone to use as we strive to provide a collaborative environment to all of Vanderbilt's community of researchers.

Cell & Developmental Biology Equipment Resource

Core Manager: AJ Rastogi
E-Mail: anuj.rastogi@vanderbilt.edu

  Website

Supports the full range of modern microscopy and digital imaging capabilities in order to enable and accelerate research that would otherwise be reduced in quantity and quality. Currently over 200 research groups use the facilities and services of the Resource, which maintains an active development program to keep the instrumentation and systems current, functional, accessible, and easy to use. CISR currently provides facilities for both optical and electron microscopy; there are six confocal microscopes, one line-scanning microscope, two 2-photon-excitation microscopes, and four advanced wide-field microscopes as well as a Phillips CM-12 120keV Transmission Electron microscope system. The laboratory is fully equipped to carry out numerous aspects of "routine" as well as specialized electron microscopy. Included in the specialized services available through the resource are: 1) preparative techniques, such as embedding and sectioning, critical point drying, high-resolution low angle and rotary shadowing, and cryo-EM; 2) research techniques, such as immuno- and enzyme-cytochemistry, autoradiography, and whole-mount microscopy; and 3) analytical techniques, such as on- and off-line microcomputer based systems for image processing, pattern analysis, and 3-D reconstruction.

Scientific Director: Matt Tyska

Director: Jenny Schafer
E-Mail: jenny.c.schafer@vanderbilt.edu

Co-Director – Electron Microscopy: Jay Jerome
E-Mail: jay.jerome@vanderbilt.edu 

Website: https://my.vanderbilt.edu/cisr/

Faculty Advisory Committee Members (2012-2013):
Elisabeth Dykens (Kennedy Center)
Jim Goldenring (Surgical Sciences)
Scott Hiebert (Cancer Center)
David Kosson (Civil and Environmental Engineering)
Mark Magnuson (Stem Cell Biology)
Richard Peek (Digestive Disease Research Center)
Al Powers (Diabetes Center)
Jeffrey Schall (Vision Research Center)
David Wasserman (Mouse Metabolic Phenotyping Center)
Chris Wright (Program in Developmental Biology)

The Vanderbilt Center for Innovative Technology (CIT) shared resource center offers full-service, flexible small molecule omics solutions via cutting-edge global untargeted and targeted ion mobility-mass spectrometry resources. The Center focuses on high-quality and innovative analytics, the development of streamlined workflows, and utilizes a collaborative approach. Potential applications include diagnostics development, nutrient metabolomics, disease mechanism &metabolome, toxicology & exposome, microbiome research, personalized medicine, and drug discovery.

Services include consultations, biostatistics, sample preparation, untargeted and targeted metabolomics, lipidomics, data processing and analysis, grant application and manuscript support and custom method development.

Read more about our services: https://www.vanderbilt.edu/cit/mass-spectrometry-technology-services
Read more about our quality-focused approach: https://www.vanderbilt.edu/cit/quality-metabolomics-research/

Core Associate: Stacy Sherrod
E-Mail: stacy.d.sherrod@vanderbilt.edu

iLab Landing Page

CIT Website

The CSB maintains a variety of instruments for studying the conformation and stability of macromolecules and for measuring the affinity and thermodynamics of biomolecular interactions.


Core Manager: Arina Hadziselimovic
E-Mail: arina.hadzi@Vanderbilt.Edu
Website: http:/structbio.vanderbilt.edu/wetlab/instrumentation.php

The mission of the CSB Shared Resources is to aid Vanderbilt researchers in protein production and biophysical characterization. We provide access to specialized reagents, instrumentation, expertise and training.

Core Manager: Arina Hadziselimovic
E-Mail: arina.hadzi@Vanderbilt.Edu

Chemical Storeroom

Core Manager:  Paulette Lynch
E-Mail:  p.lynch@vanderbilt.edu

Core Manager: Magdalena Paszewsk
E-Mail:  magdalena.k.paszewska@vanderbilt.edu

Chemistry PowerX-Ray Diffraction (XRD) Core

Core Manager:  Janet Macdonald
E-Mail:  janet.macdonald.edu

Core Manager: Magdalena Paszewsk
E-Mail:  magdalena.k.paszewska@vanderbilt.edu

The Computational Structural and Chemical Biology Core brings customized structural biology and chemical biology insights to your research, facilitating hypothesis generation and guiding experimental design. We offer state-of-the-art molecular visualization, structural analysis, ligand-based modeling, and structure/activity predictions that are designed to accelerate discovery.

Operations Director: Jarrod Smith
E-Mail: jarrod.smith@vanderbilt.edu

A new disk storage device called DORS is now mounted on ACCRE via collaboration between the Center for Structural Biology, the VUMC Office of Research, VUIT and ACCRE.

Director: Jarrod Smith, Ph.D.
E-Mail: jarrod.smith@Vanderbilt.Edu
Phone: (615) 554-5681
Website: http://www.accre.vanderbilt.edu/?page_id=1729

Director: Robert Reed 

E-Mail: robert.reed@Vanderbilt.Edu
Phone: 615-343-2702
Website: http://www.accre.vanderbilt.edu/?page_id=1729

Director: Caroline E Roe

E-Mail: caroline.e.roe@Vanderbilt.Edu
Website: https://my.vanderbilt.edu/mcce/

Provides instrumentation for structural analysis of biological molecules and qualitative and quantitative assays of chemotherapeutic agents and metabolites in physiological fluids. The instrumentation facilities consist of a variety of mass spectrometric and high-pressure liquid chromatographic systems.

Learn more about MSRC's core capabilities, educational opportunities, and current research: Watch the video.

Mass Spectrometry Core

Provides instrumentation for structural analysis of biological molecules and qualitative and quantitative assays of chemotherapeutic agents and metabolites in physiological fluids. The instrumentation facilities consist of a variety of mass spectrometric and high-pressure liquid chromatographic systems.

Director: Kevin Schey
Assistant Director: Wade Calcutt
E-Mail: wade.calcutt@Vanderbilt.Edu
Website: http://www.mc.vanderbilt.edu/root/vumc.php?site=msrc/mass_spectrometry_core_lab

Faculty Advisory Committee Members (2012-2013):
Michael Aschner (Molecular Toxicology)
Alan Brash (Clinical Pharmacology) 
Roger Colbran (Molecular Physiology and Biophysics) 
Sean Davis (Clinical Pharmacology) 
Fred Guengerich (Biochemistry) 
Scott Hiebert (VICC) 
Larry Marnett (VICB) 
Claus Schneider (Clinical Pharmacology) 
Eric Skaar (Pathology, Microbiology and Immunology) 


 Proteomics Core

Provides state-of-the-art instrumentation and expertise in analytical proteomics, proteome profiling, and imaging to Vanderbilt researchers. Instrumentation is available for protein and peptide separations by 2D-gel electrophoresis and multidimensional high performance liquid chromatography (LC).

Proteins and peptides of interest are processed and subjected to mass spectral (MS) analysis, and protein identifications are made based on a comparison of MS data with sequence information from genomic, protein, and EST databases. Proteome profiling and imaging in frozen tissue sections are done by matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) MS. Proteomics Laboratory staff provide consultation on experimental design and sample preparation.

Director: Kevin Schey

Co-Associate Director: Hayes McDonald

E-Mail: hayes.mcdonald@vanderbilt.edu

Website: http://www.mc.vanderbilt.edu/root/vumc.php?site=msrc/proteomics_core

Tissue/Serum Proteomics Core Director: Richard Caprioli
Website: http://www.mc.vanderbilt.edu/root/vumc.php?site=msrc/tissuecore

Faculty Advisory Committee Members (2012-2013):
Roger Colbran (Molecular Physiology and Biophysics)
David Cortez (Biochemistry)
Timothy Cover (Infectious Disease)
Scott Hiebert (Cancer Center)
Andrew Link (Pathology, Microbiology and Immunology)
Larry Marnett (Institute for Chemical Biology)
Richard Peek (Digestive Disease Research Center )
 


 

Tissue/Serum Proteomics Core

Offers a variety of services in order to determine the proteomic profiles of tissue, serum, and other biological fluids using MALDI mass spectrometry. Investigators work closely with Core personnel in order to design the experiment that will best answer the scientific questions being posed. The typical study involves examining protein changes between two experimental groups; e.g., control vs. diseased or treated vs. nontreated. The services offered by the Tissue/Serum Proteomics Core include tissue profiling, tissue imaging, 1D and 2D robotic biofluid fractionation and protein profiling, and multidimensional LC-MS/MS “shotgun” proteomics analysis of biofluids and tissue homogenates. In addition, various biocomputational services are offered in conjunction with data acquisition, including biostatistical comparisons of sample groups and image processing.

Director: Richard Caprioli
Website: http://www.mc.vanderbilt.edu/root/vumc.php?site=msrc/tissuecore

The Mouse Metabolic Phenotyping Center provides investigators wishing to address hypotheses related to diabetes and metabolism with a range of animal model systems. Assistance with mouse experimentation falls under the auspices of the Mouse Metabolic Phenotyping Center, which branched off from this core in 2001. Expertise of core personnel reflects the need to assist in both small and large animal experiments. Services provided are surgical, experimental, with limited analytical capacity (blood glucose, serology). Emphasis is on procedures needed to study conscious, unrestrained animals. Equipment available to investigators includes infusion pumps, blood flow meters, blood pressure monitors, gas analyzers, centrifuges, and glucose analyzers. The Animal Resources Core is experienced in developing new procedures and animal models to accommodate evolving research needs. Many of the procedures conducted in this core are novel. For this reason, training of investigators is an important responsibility of the Animal Resources Core.

Director: David Wasserman
E-mail: mmpc@vanderbilt.edu
Website: https://labnodes.vanderbilt.edu/mmpc

We offer UNIX/Linux computer system support, including networking and software support for workstations, printers, and server-class systems. We can also offer limited services for Windows and Macintosh systems, where appropriate. The cost of service per system varies depending on system type, system function, and other factors that relate to the amount of support required to maintain the system.

Core Director: Jarrod SMith
E-Mail: jarrod.smith@vanderbilt.edu

VAPR partners with scientists across the country to design, develop, and evaluate all the molecular tools and assays needed to drive research forward.

Associate Professor: Benjamin Spiller
E-mail: vapr@vanderbilt.edu
Phone: (615) 322-5623
Website: https://medschool.vanderbilt.edu/vapr/

Neurochemistry Core Laboratory

Offers services for neurochemical profiling of brain, peripheral tissues and body fluids. The core provides analytical services for the quantitation of multiple biogenic amine neurotransmitters (e.g. dopamine, norepinephrine, serotonin, acetylcholine), biogenic amine metabolites, amino acids and amino acid neurotransmitters (e.g. glutamate, GABA). Investigators provide primary tissue samples or extracts stabilized for analysis.

Core Director: Ginger Milne
E-Mail: ginger.milne@vanderbilt.edu
Phone: (615) 936-5611
Website:  http://www.mc.vanderbilt.edu/root/vumc.php?site=neurosci&doc=697

Rat and Mouse Neurobehavior Cores

This facility provides infrastructure and guidance to support the assessment of behavior in genetically altered mice. Automated, computer-controlled instrumentation provides for assessment of motor and cognitive behavior as well as drug responses. MNL core personnel consult with investigators on experimental design and train core users in animal handling, data acquisition, and statistical analysis. Core personnel may also assist with writing methods and results sections for manuscripts or grants.


Murine Neurobehavioral Laboratory

This facility provides infrastructure and guidance to support the assessment of behavior in genetically altered mice. Automated, computer-controlled instrumentation provides for assessment of motor and cognitive behavior as well as drug responses. MNL core personnel consult with investigators on experimental design and train core users in animal handling, data acquisition, and statistical analysis. Core personnel may also assist with writing methods and results sections for manuscripts or grants.

Manager: John Allison
E-Mail: john.d.allison@vanderbilt.edu
Phone: (615) 322-0794
Website: http://www.vandymouse.org/

Provides equipment, training and consulting for Vanderbilt personnel who are interested in studying rat models of both neurological and psychiatric disorders. Examples of assays available for research in rats include models of anxiety, depression, drug abuse, learning and memory, cognition, attention, social interaction, pain, motor activity and coordination. Investigators can employ the latest technology in video capture and software-based analysis of behavior.


Rat Neurobehavioral Laboratory

Provides equipment, training and consulting for Vanderbilt personnel who are interested in studying rat models of both neurological and psychiatric disorders. Examples of assays available for research in rats include models of anxiety, depression, drug abuse, learning and memory, cognition, attention, social interaction, pain, motor activity and coordination. Investigators can employ the latest technology in video capture and software-based analysis of behavior.

Contact: Carrie Jones or Lisa Wright
E-Mail: carrie.jones@vanderbilt.edu or lisa.m.wright@vanderbilt.edu
Phone: (615) 343-4337
Website: https://medschool.vanderbilt.edu/rat-core/

VBI Instrument Core

The Vanderbilt Brain Institute maintains this large and diverse set of instruments located throughout MRB3. Equipment is pay/per use and available for anyone to use as we strive to provide a collaborative environment to all of Vanderbilt’s community of researchers.

Manager: AJ Rastogi
E-Mail: anuj.rastogi@vanderbilt.edu
Website: https://lab.vanderbilt.edu/vbi-core-labs/vbi-equipment-resource

Creative Data Solutions is a Vanderbilt Shared that provides bioinformatics and informatics research services. Its vision is to have a measurable impact on the ability of research investigators to both publish their work and obtain new funding. Its core values include:

  • Promote bioinformatics and advanced computation to augment our ability to achieve a solutions-driven approach to life science problems.
  • Maintain a strong informatics skill-set necessary for unraveling and integrating datasets originating from various sources and technologies.
  • Developing visually pleasing and understandable mixed-media and visual solutions, in order to best communicate data and resulting knowledge.

Director: Jean-Philippe Cartailler
E-Mail: jp.cartailler@Vanderbilt.Edu
Website: https://cds.vanderbilt.edu

The Vanderbilt Center for Stem Cell Biology aims to understand the biology of stem cells and the mechanisms for directing their differentiation to specific cell fates.

The Vanderbilt Genome Editing Resource (VGER) assists investigators in generating, maintaining and storing germline-altered mice in an efficient and cost-effective manner. The VGER provides services, consultation, and collaborations to enable the generation, storage and regeneration of genetically altered mice at Vanderbilt. This resource, which was previously called the Transgenic Mouse ESC Shared Resource, has been in existence for over 25 years and has generated 200 unique gene-targeted mice between 1993-2015 and more than 100 genome edited mice using CRISPR-Cas9 since 2014.

The Vanderbilt Cryopreserved Mouse Repository (VCMR) contains unique cryopreserved mouse strains that have been derived and donated by Vanderbilt investigators. These strains are available for rederivation or shipment by investigators.

We have many years of experience in generating novel transgenic mouse models and are happy to discuss your project with you.

     Director: Mark Magnuson

     E-Mail: Mark.Magnuson@Vanderbilt.Edu

     Manager: Jennifer Skelton

     E-Mail: Jennifer.Skelton@Vanderbilt.Edu

     VGER Website: https://labnodes.vanderbilt.edu/vger

     VCMR Website: https://labnodes.vanderbilt.edu/vcmr

We have developed a highly dynamic environment that utilizes industry standard practices and novel technologies for biological screening.

            Director: Joshua Bauer

            E-Mail: joshua.a.bauer@vanderbilt.edu

            Website:  http://www.vanderbilt.edu/hts/

The Vanderbilt MicroFabrication Core specializes in the design, fabrication, and production of custom biological microfluidic mechanotronic (BioMicroMech) instruments, with emphasis on hybrid polymeric microfluidic devices with thin-film and optical sensors and computerized fluidic control.

Our typical products include fluidic networks, cost-effective pumps, various chemotaxis chambers and gradient generators, on-chip valves, multilayer devices, arrays of microfabricated traps and elements for cellular study, implantable devices for in vivo imaging, liquid and gas control systems, biological habitats and environments, 3D scaffolds and microbioreactors, all of which are fully customizable. Consultants are available to discuss your specific needs and produce devices and instruments for your research.

 

Vanderbilt MicroFabrication Core Director:  David Schaffer | d.schaffer@vanderbilt.edu
                                                                                  

Website:   https://www.vanderbilt.edu/vmfc/

 

Vanderbilt MicroFabrication Core Administrative Manager:   Amber Miller | amber.miller@vanderbilt.edu

 

 

Welcome to the website of the Vanderbilt Institute of Nanoscale Science and Engineering –– VINSE!

VINSE is comprised of 45 faculty members from the College of Arts and Science, the School of Engineering, and the School of Medicine.  Created in 2001 with Academic Venture Capital Fund support from Vanderbilt’s endowment, VINSE hit the ground running by quickly building a small suite of laboratories for nanofabrication and nanocharacterization and working cooperatively with many departments to hire a cadre of nanoscience-oriented faculty.  Our primary research areas include nanobio/nanomedicine, nano-energy, nanoscale optics, computational nanoscience, and new nanoscale materials.  We have built graduate, undergraduate, and outreach educational programs while growing our faculty and adding additional experimental capabilities.  VINSE faculty now span 13 academic departments; our graduate educational arm is the Interdisciplinary Program in Materials Science; our undergraduate program is the Minor in Nanoscience and Nanotechnology; we organize classroom visitation and on-site High School Field Trip outreach programs; and we are building an expanded suite of core facilities in the new Engineering and Science Building. 

Every single day, VINSE faculty, staff and students stretch the boundaries of nanoscience to advance our research, education, and outreach missions while fully embracing Vanderbilt University’s values of equality, collegiality, compassion and excellence in all endeavors.

VINSE Cleanroom

VINSE EBL

VINSE MERLIN SEM Center

VINSE Nanocrystal Laboratory

VINSE SEM

VINSE Osiris TEM 

VINSE XPS Center

Core Manager: Alisha McCord
E-Mail:  alisa.d.mccord@vanderbilt.edu

Website:  http://www.vanderbilt.edu/vinse/

Currently the Small Molecule NMR Facility Core is comprised of five Bruker NMR spectrometers ranging from 300-600 MHz. Researchers interested in accessing the Small Molecule NMR Facility Core are encouraged to explore this webpage or contact Facility Director directly (Donald Stec, Ph.D.; donald.f.stec@vanderbilt.edu) with any questions regarding Facility access and/or capabilities.

             Director: Don Stec

            E-Mail: donald.f.stec@Vanderbilt.Edu

            Website:  https://medschool.vanderbilt.edu/annmr/

The Chemical Synthesis Core was established within the Vanderbilt Institute of Chemical Biology to support the organic and medicinal chemistry needs of Vanderbilt investigators. The primary focus of the core is to facilitate biology-oriented projects within the medical center and the university by assisting with the chemistry aspect of the project. The core works independently or in collaboration with the VICB High Throughput Screening Center on the synthesis of literature-cited compounds (including patented ones) as well as full scale lead optimization of a compound.

Director: Gary Sulikowski
E-mail: gary.a.sulikowski@vanderbilt.Edu

Assistant Director: Kwangho Kim
E-mail: kwangho.kim@vanderbilt.Edu
Phone: (615) 322-7324


Website: https://medschool.vanderbilt.edu/syncore/

VUMC Cores:

Please visit https://www.vumc.org/oor/shared-resources-and-core-facilities