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Cores Facilities

U Cores:
  • ACCRE – Advanced Computing Center for Research and Education


    The Advanced Computing Center for Research and Education is comprised of High Performance Computing services that provide an environment for a wide variety of research projects across Vanderbilt. These services include: High Performance Computing *** Non-cluster Tape Backup Services Logistical Storage (L-Store) The Research and Education Data Depot Network (REDDnet)

    Director:  Carie Lee Kennedy
    E-Mail:  clk@accre.vanderbilt.edu

    Website: http://www.accre.vanderbilt.edu/

  • Biomolecular NMR Facility

     

    The principal mission of the Biomolecular NMR Center is to provide instrumentation for, and aid in obtaining data on the structure and dynamics of biological macromolecules. The Facility offers state-of-the-art instrumentation, training, software and assistance in designing experiments. We strive to help the Vanderbilt community realize the potential of biomolecular NMR and to work with NMR spectroscopists to stay current with the most recent experimental approaches.


    Director: Markus Voehler
    E-Mail: m.voehler@vanderbilt.edu

    Website: http://structbio.vanderbilt.edu/nmr/user_info/userInfo.php

  • Bret Poster Printing Service


    The BRET Office of Postdoctoral Affairs (OPA) assists postdoctoral fellows during their training at Vanderbilt University Medical Center (VUMC). Our office makes postdoctoral appointments and reappointments. We meet with postdoctoral candidates upon faculty request and with new postdoctoral fellows focusing on the Compact Between Postdoctoral Appointees and their MentorsIndividual Development Plan and resources available, including resources to aid postdocs in developing writing and presentation skills.  The BRET Office of Postdoctoral Affairs sponsors the Vanderbilt Postdoctoral Association which welcomes all Vanderbilt postdoctoral fellows from all schools to PDA events such as;the PDA and Shared Resources Poster Symposium and Research Day, monthly meetings, holiday events and celebration ofNational Postdoc Appreciation Weekwith the Postdoc Family Picnic.The Scientist'sannual survey has consistently ranked Vanderbilt as one of the best places for postdocs to work in the United States. Whether you are a prospective postdoctoral fellow considering a move to Nashville or a current postdoctoral fellow seeking assistance, we are here to offer our support.

    Core Manager: Karen Perry
    E-Mail: karen.perry@vanderbilt.edu

    Website:  https://medschool.vanderbilt.edu/postdoc/

  • Cancer & Immunology Core (CIC)


    The Cancer & Immunology Core (CIC) provides access to mass cytometry and other advanced cytometry services for cancer and immunology research. The CIC uses well-established reagent sets and protocols to help researchers get a first mass cytometry figure or to carry out studies in areas where the technology development has been robust, such as monitoring human T cell subsets.

    Core Manager:  Caroline Roe
    E-Mail: caroline.e.roe@vanderbilt.edu

    Scientific Director:  Jonathan Irish, Ph.D.
    E-Mail: jonathan.irish@vanderbilt.edu

    Website:  https://my.vanderbilt.edu/cancerimmunology/

  • Cell & Development Biology Equipment Resources (CDB)


    The Department of Cell and Development BIology maintains this large and diverse set of instruments located throughout MRB3 and MCN. Equipment is pay/per use and available for anyone to use as we strive to provide a collaborative environment to all of Vanderbilt's community of researchers.

    Cell & Developmental Biology Equipment Resource

    Core Manager: Josh Luffman
    E-Mail: josh.luffman@Vanderbilt.Edu

      Website

  • Cell Imaging Shared Resource (CISR)


    Supports the full range of modern microscopy and digital imaging capabilities in order to enable and accelerate research that would otherwise be reduced in quantity and quality. Currently over 200 research groups use the facilities and services of the Resource, which maintains an active development program to keep the instrumentation and systems current, functional, accessible, and easy to use. CISR currently provides facilities for both optical and electron microscopy; there are six confocal microscopes, one line-scanning microscope, two 2-photon-excitation microscopes, and four advanced wide-field microscopes as well as a Phillips CM-12 120keV Transmission Electron microscope system. The laboratory is fully equipped to carry out numerous aspects of "routine" as well as specialized electron microscopy. Included in the specialized services available through the resource are: 1) preparative techniques, such as embedding and sectioning, critical point drying, high-resolution low angle and rotary shadowing, and cryo-EM; 2) research techniques, such as immuno- and enzyme-cytochemistry, autoradiography, and whole-mount microscopy; and 3) analytical techniques, such as on- and off-line microcomputer based systems for image processing, pattern analysis, and 3-D reconstruction.

    Scientific Director: Matt Tyska

    Director: Jenny Schafer
    E-Mail: jenny.c.schafer@vanderbilt.edu

    Co-Director – Electron Microscopy: Jay Jerome
    E-Mail: jay.jerome@vanderbilt.edu 

    Website: http://cisrweb.mc.vanderbilt.edu/CISR/index.php

    Faculty Advisory Committee Members (2012-2013):
    Elisabeth Dykens (Kennedy Center)
    Jim Goldenring (Surgical Sciences)
    Scott Hiebert (Cancer Center)
    David Kosson (Civil and Environmental Engineering)
    Mark Magnuson (Stem Cell Biology)
    Richard Peek (Digestive Disease Research Center)
    Al Powers (Diabetes Center)
    Jeffrey Schall (Vision Research Center)
    David Wasserman (Mouse Metabolic Phenotyping Center)
    Chris Wright (Program in Developmental Biology)

  • Center for Innovative Technology (CIT)


    The Vanderbilt Center for Innovative Technology (CIT) recharge center will be an analytical facility specializing in a range of cutting edge mass spectrometry (MS) and confocal microscopy techniques. The center will provide the infrastructure and expertise to measure both targeted and broad spectrum untargeted molecules derived from biospecimens (cells, tissues, fluids, etc). There will be an emphasis on the use and development of technologies including ion mobility MS, for analyses of diverse samples ranging from basic cell culture models to effluent of advanced systems such as organ-on-chip microfluidic or 3-dimensional devices. 

    Core Manager: Heather Watkins
    E-Mail: heather.l.watkins@vanderbilt.edu

    Core Associate: Stacy Sherrod
    E-Mail: stacy.d.sherrod@vanderbilt.edu

    iLab Landing Page

  • Center for Structural Biology


    CSB Computing Service Center

    CSB NMR

    CSB Biophysical Instrumentation

    CSB MegaLab

    CSB Modeling

    Core Manager:  Lisa Wright
    E-Mail:  lisa.m.wright@vanderbilt.edu

  • Chemical Storeroom


    Chemical Storeroom

    Core Manager:  Paulette Lynch
    E-Mail:  p.lynch@vanderbilt.edu

    Core Manager: Magdalena Paszewsk
    E-Mail:  magdalena.k.paszewska@vanderbilt.edu

  • Chemistry XRD


    Chemistry PowerX-Ray Diffraction (XRD) Core

    Core Manager:  Janet Macdonald
    E-Mail:  janet.macdonald.edu

    Core Manager: Magdalena Paszewsk
    E-Mail:  magdalena.k.paszewska@vanderbilt.edu

  • Distributed Online Research Storage (DORS)


    A new disk storage device called DORS is now mounted on ACCRE via collaboration between the Center for Structural Biology, the VUMC Office of Research, VUIT and ACCRE.

    Director: Jarrod Smith, Ph.D.
    E-Mail: jarrod.smith@Vanderbilt.Edu
    Phone: (615) 554-5681
    Website: http://www.accre.vanderbilt.edu/?page_id=1729

  • ISDE Radiation Effects Laboratory


    Director: Robert Reed 

    E-Mail: robert.reed@Vanderbilt.Edu
    Phone: 615-343-2702
    Website: http://www.accre.vanderbilt.edu/?page_id=1729

  • MCCE Mass Cytometry Center of Excellence


    Director: Caroline E Roe

    E-Mail: caroline.e.roe@Vanderbilt.Edu
    Website: https://my.vanderbilt.edu/mcce/

  • MSRC - Mass Spectrometry Research Center


    Provides instrumentation for structural analysis of biological molecules and qualitative and quantitative assays of chemotherapeutic agents and metabolites in physiological fluids. The instrumentation facilities consist of a variety of mass spectrometric and high-pressure liquid chromatographic systems.

    Learn more about MSRC's core capabilities, educational opportunities, and current research: Watch the video.

    Mass Spectrometry Core

    Provides instrumentation for structural analysis of biological molecules and qualitative and quantitative assays of chemotherapeutic agents and metabolites in physiological fluids. The instrumentation facilities consist of a variety of mass spectrometric and high-pressure liquid chromatographic systems.

    Director: Kevin Schey
    Assistant Director: Wade Calcutt
    E-Mail: wade.calcutt@Vanderbilt.Edu
    Website: http://www.mc.vanderbilt.edu/root/vumc.php?site=msrc/mass_spectrometry_core_lab

    Faculty Advisory Committee Members (2012-2013):
    Michael Aschner (Molecular Toxicology)
    Alan Brash (Clinical Pharmacology) 
    Roger Colbran (Molecular Physiology and Biophysics) 
    Sean Davis (Clinical Pharmacology) 
    Fred Guengerich (Biochemistry) 
    Scott Hiebert (VICC) 
    Larry Marnett (VICB) 
    Claus Schneider (Clinical Pharmacology) 
    Eric Skaar (Pathology, Microbiology and Immunology) 


     Proteomics Core

    Provides state-of-the-art instrumentation and expertise in analytical proteomics, proteome profiling, and imaging to Vanderbilt researchers. Instrumentation is available for protein and peptide separations by 2D-gel electrophoresis and multidimensional high performance liquid chromatography (LC).

    Proteins and peptides of interest are processed and subjected to mass spectral (MS) analysis, and protein identifications are made based on a comparison of MS data with sequence information from genomic, protein, and EST databases. Proteome profiling and imaging in frozen tissue sections are done by matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) MS. Proteomics Laboratory staff provide consultation on experimental design and sample preparation.

    Director: Kevin Schey

    Co-Associate Director: Hayes McDonald

    E-Mail: hayes.mcdonald@vanderbilt.edu

    Website: http://www.mc.vanderbilt.edu/root/vumc.php?site=msrc/proteomics_core

    Tissue/Serum Proteomics Core Director: Richard Caprioli
    Website: http://www.mc.vanderbilt.edu/root/vumc.php?site=msrc/tissuecore

    Faculty Advisory Committee Members (2012-2013):
    Roger Colbran (Molecular Physiology and Biophysics)
    David Cortez (Biochemistry)
    Timothy Cover (Infectious Disease)
    Scott Hiebert (Cancer Center)
    Andrew Link (Pathology, Microbiology and Immunology)
    Larry Marnett (Institute for Chemical Biology)
    Richard Peek (Digestive Disease Research Center )
     


     

    Tissue/Serum Proteomics Core

    Offers a variety of services in order to determine the proteomic profiles of tissue, serum, and other biological fluids using MALDI mass spectrometry. Investigators work closely with Core personnel in order to design the experiment that will best answer the scientific questions being posed. The typical study involves examining protein changes between two experimental groups; e.g., control vs. diseased or treated vs. nontreated. The services offered by the Tissue/Serum Proteomics Core include tissue profiling, tissue imaging, 1D and 2D robotic biofluid fractionation and protein profiling, and multidimensional LC-MS/MS “shotgun” proteomics analysis of biofluids and tissue homogenates. In addition, various biocomputational services are offered in conjunction with data acquisition, including biostatistical comparisons of sample groups and image processing.

    Director: Richard Caprioli
    Website: http://www.mc.vanderbilt.edu/root/vumc.php?site=msrc/tissuecore

  • Mouse Metabolic Phenotyping Center (MMPC)


    The Mouse Metabolic Phenotyping Center provides investigators wishing to address hypotheses related to diabetes and metabolism with a range of animal model systems. Assistance with mouse experimentation falls under the auspices of the Mouse Metabolic Phenotyping Center, which branched off from this core in 2001. Expertise of core personnel reflects the need to assist in both small and large animal experiments. Services provided are surgical, experimental, with limited analytical capacity (blood glucose, serology). Emphasis is on procedures needed to study conscious, unrestrained animals. Equipment available to investigators includes infusion pumps, blood flow meters, blood pressure monitors, gas analyzers, centrifuges, and glucose analyzers. The Animal Resources Core is experienced in developing new procedures and animal models to accommodate evolving research needs. Many of the procedures conducted in this core are novel. For this reason, training of investigators is an important responsibility of the Animal Resources Core.

    Director: David Wasserman
    E-mail: mmpc@vanderbilt.edu
    Website: https://labnodes.vanderbilt.edu/mmpc

  • Vanderbilt Antibody and Protein Resource (VAPR) Core


    VAPR partners with scientists across the country to design, develop, and evaluate all the molecular tools and assays needed to drive research forward.

    Director: Paige Vinson
    E-mail: vapr@vanderbilt.edu
    Phone: (615) 322-5623
    Website: https://medschool.vanderbilt.edu/vapr/

  • Vanderbilt Brain Institute (VBI) Neurochemistry Core

    Neurochemistry Core Laboratory

    Offers services for neurochemical profiling of brain, peripheral tissues and body fluids. The core provides analytical services for the quantitation of multiple biogenic amine neurotransmitters (e.g. dopamine, norepinephrine, serotonin, acetylcholine), biogenic amine metabolites, amino acids and amino acid neurotransmitters (e.g. glutamate, GABA). Investigators provide primary tissue samples or extracts stabilized for analysis.

    Core Director: Ginger Milne
    E-Mail: ginger.milne@vanderbilt.edu
    Phone: (615) 936-5611
    Website:  http://www.mc.vanderbilt.edu/root/vumc.php?site=neurosci&doc=697

  • Vanderbilt Brain Institute (VBI) Mouse Neurobehavioral Lab (MNL)

    Rat and Mouse Neurobehavior Cores

    This facility provides infrastructure and guidance to support the assessment of behavior in genetically altered mice. Automated, computer-controlled instrumentation provides for assessment of motor and cognitive behavior as well as drug responses. MNL core personnel consult with investigators on experimental design and train core users in animal handling, data acquisition, and statistical analysis. Core personnel may also assist with writing methods and results sections for manuscripts or grants.


    Murine Neurobehavioral Laboratory

    This facility provides infrastructure and guidance to support the assessment of behavior in genetically altered mice. Automated, computer-controlled instrumentation provides for assessment of motor and cognitive behavior as well as drug responses. MNL core personnel consult with investigators on experimental design and train core users in animal handling, data acquisition, and statistical analysis. Core personnel may also assist with writing methods and results sections for manuscripts or grants.

    Manager: John Allison
    E-Mail: john.d.allison@vanderbilt.edu
    Phone: (615) 322-0794
    Website: http://www.vandymouse.org/

    Provides equipment, training and consulting for Vanderbilt personnel who are interested in studying rat models of both neurological and psychiatric disorders. Examples of assays available for research in rats include models of anxiety, depression, drug abuse, learning and memory, cognition, attention, social interaction, pain, motor activity and coordination. Investigators can employ the latest technology in video capture and software-based analysis of behavior.


    Rat Neurobehavioral Laboratory

    Provides equipment, training and consulting for Vanderbilt personnel who are interested in studying rat models of both neurological and psychiatric disorders. Examples of assays available for research in rats include models of anxiety, depression, drug abuse, learning and memory, cognition, attention, social interaction, pain, motor activity and coordination. Investigators can employ the latest technology in video capture and software-based analysis of behavior.

    Contact: Carrie Jones or Lisa Wright
    E-Mail: carrie.jones@vanderbilt.edu or lisa.m.wright@vanderbilt.edu
    Phone: (615) 343-4337
    Website: https://medschool.vanderbilt.edu/rat-core/

  • Vanderbilt Brain Institute (VBI) Instrument Core

    VBI Instrument Core

    The Vanderbilt Brain Institute maintains this large and diverse set of instruments located throughout MRB3. Equipment is pay/per use and available for anyone to use as we strive to provide a collaborative environment to all of Vanderbilt’s community of researchers.

    Manager: Josh Luffman
    E-Mail: josh.luffman@vanderbilt.edu
    Website: https://lab.vanderbilt.edu/vbi-core-labs/vbi-equipment-resource

  • Vanderbilt Creative Date Solutions

     

    The Vanderbilt Center for Stem Cell Biology aims to understand the biology of stem cells and the mechanisms for directing their differentiation to specific cell fates.

    Vanderbilt Creative Data Solutions

    Creative Data Solutions is a Vanderbilt Shared Resource and has extensive experience in providing effective and robust solutions to challenges pertaining to research data using modern informatics and bioinformatics approaches.

    We provide a wide array of services that are essential to support these goals.

                  Director: Jean-Philippe Cartailler

                  E-Mail:  jp.cartailler@Vanderbilt.Edu

                  Website:  https://labnodes.vanderbilt.edu/community/profile/id/2169

  • Vanderbilt Genome Editing Resource

     

    The Vanderbilt Center for Stem Cell Biology aims to understand the biology of stem cells and the mechanisms for directing their differentiation to specific cell fates.

    The Vanderbilt Genome Editing Resource (VGER) assists investigators in generating, maintaining and storing germline-altered mice in an efficient and cost-effective manner. The VGER provides services, consultation, and collaborations to enable the generation, storage and regeneration of genetically altered mice at Vanderbilt.  This resource, which was previously called the Transgenic Mouse ESC Shared Resource, has been in existence for over 25 years and has generated 160 unique gene-targeted mice between 1993-2015 and more than 70 genome edited mice using CRISPR-Cas9 since 2014.

    We have many years of experience in generating novel transgenic mouse models and are happy to discuss your project with you.

                 Director: Mark Magnuson

                E-Mail: Mark.Magnuson@Vanderbilt.Edu

                Manager: Jennifer Skelton

                E-Mail: Jennifer.Skelton@Vanderbilt.Edu

                Website:  http://labnodes.vanderbilt.edu/tmescsr

  • Vanderbilt High Throughput Screening Core Group

     

    We have developed a highly dynamic environment that utilizes industry standard practices and novel technologies for biological screening.

                 Director: Paige Vinson/p>

                E-Mail: paige.n.vinson@Vanderbilt.Edu

                Website:  http://www.vanderbilt.edu/hts/

  • Vanderbilt Institute for Integrative Biosystems Research and Education (VIIBRE)


    VIIBRE, the Vanderbilt Institute for Integrative 
    Biosystems   Research and Education, was created in 2001 with a $5 million, five-year grant from the Vanderbilt Academic Venture Capital Fund to foster and enhance interdisciplinary research in innovative systems biology and systems engineering at Vanderbilt, integrated with a strong focus on undergraduate, graduate, and postdoctoral education.

    VIIBRE's mission is to invent the tools and develop the skills that are required to conduct research in systems biology - in other words, to elucidate the multitude of intracellular metabolic and signaling control mechanisms by which biological systems regulate homeostasis, differentiation, development, growth, repair, and responses to physiological and environmental stimuli. Control of cellular function is ubiquitous among living systems and occurs over spatiotemporal scales that range from rapid local control of transient molecular signaling events to slower regulatory mechanisms governing biological activity throughout an entire organism over its lifespan. This spatiotemporal breadth presents measurement and modeling challenges that require a coordinated, collaborative effort by scientists, engineers, and physicians whose expertise spans multiple disciplines.

    Taking advantage of Vanderbilt's existing strengths in science, medicine, engineering, and education, VIIBRE has instituted a broad program in  BioMicroElectroMechanical systems ( BioMEMS ) and advanced analytical and optical instrumentation and software to address pressing questions in systems biology. VIIBRE's activities are carried out in on- and off-campus collaborations in research areas such as cellular biosensors, bioprocess controllers, mathematical models for wound healing and cancer, infectious disease detection, biomedical imaging, and cellular/tissue engineering. One of VIIBRE's long-term challenges is to design and build hybrid silicon/biological systems (microfluidic cell habitats) that propose and generate models and conduct experiments on themselves to identify the principles (represented by mathematical equations) that describe cellular metabolic and signaling dynamics.

    To date, VIIBRE has helped bring to Vanderbilt over $70 million of new external funding. VIIBRE is now primarily funded by external grants and contracts.

    VIIBRE Automated Micro-Organ Systen

    VIIBRE Microfabrication Core

    Core Manager:  Sarazen Haile
    E-Mail:  sarazen.kokodynsky@vanderbilt.edu

    Website:  http://www.vanderbilt.edu/viibre/

  • Vanderbilt Institute of Nanoscale Science and Engineering (VINSE)


    Welcome to the website of the Vanderbilt Institute of Nanoscale Science and Engineering –– VINSE!

    VINSE is comprised of 45 faculty members from the College of Arts and Science, the School of Engineering, and the School of Medicine.  Created in 2001 with Academic Venture Capital Fund support from Vanderbilt’s endowment, VINSE hit the ground running by quickly building a small suite of laboratories for nanofabrication and nanocharacterization and working cooperatively with many departments to hire a cadre of nanoscience-oriented faculty.  Our primary research areas include nanobio/nanomedicine, nano-energy, nanoscale optics, computational nanoscience, and new nanoscale materials.  We have built graduate, undergraduate, and outreach educational programs while growing our faculty and adding additional experimental capabilities.  VINSE faculty now span 13 academic departments; our graduate educational arm is the Interdisciplinary Program in Materials Science; our undergraduate program is the Minor in Nanoscience and Nanotechnology; we organize classroom visitation and on-site High School Field Trip outreach programs; and we are building an expanded suite of core facilities in the new Engineering and Science Building. 

    Every single day, VINSE faculty, staff and students stretch the boundaries of nanoscience to advance our research, education, and outreach missions while fully embracing Vanderbilt University’s values of equality, collegiality, compassion and excellence in all endeavors.

    VINSE Cleanroom

    VINSE EBL

    VINSE MERLIN SEM Center

    VINSE Nanocrystal Laboratory

    VINSE SEM

    VINSE Osiris TEM 

    VINSE XPS Center

    Core Manager: Alisha McCord
    E-Mail:  alisa.d.mccord@vanderbilt.edu

    Website:  http://www.vanderbilt.edu/vinse/

  • Vanderbilt Small Molecule NMR Facilty

     

    Currently the Small Molecule NMR Facility Core is comprised of five Bruker NMR spectrometers ranging from 300-600 MHz. Researchers interested in accessing the Small Molecule NMR Facility Core are encouraged to explore this webpage or contact Facility Director directly (Donald Stec, Ph.D.; donald.f.stec@vanderbilt.edu) with any questions regarding Facility access and/or capabilities.

                 Director: Don Stec/p>

                E-Mail: donald.f.stec@Vanderbilt.Edu

                Website:  https://medschool.vanderbilt.edu/annmr/

  • Vanderbilt VICB Chemical Synthesis Core


    The Chemical Synthesis Core was established within the Vanderbilt Institute of Chemical Biology to support the organic and medicinal chemistry needs of Vanderbilt investigators. The primary focus of the core is to facilitate biology-oriented projects within the medical center and the university by assisting with the chemistry aspect of the project. The core works independently or in collaboration with the VICB High Throughput Screening Center on the synthesis of literature-cited compounds (including patented ones) as well as full scale lead optimization of a compound.

    Director: Gary Sulikowski
    E-mail: gary.a.sulikowski@vanderbilt.Edu

    Assistant Director: Kwangho Kim
    E-mail: kwangho.kim@vanderbilt.Edu
    Phone: (615) 322-7324


    Website: https://medschool.vanderbilt.edu/vapr/

VUMC Cores:

Please visit https://www.vumc.org/oor/shared-resources-and-core-facilities