May 2015 Issue
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Analyzing the Role of RIF1 in DNA Double-Strand Break Repair
This work uncovers that the function of RIF1 in DNA Double-Strand Break repair is likely mediated through the Single-Strand Annealing form of Homology-Directed RepairKatherine Friedman, Yae Eun Yang | May 1, 2015
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A Hybrid Photometric and Spectral Algorithm for Efficient Detection of Gravitationally Lensed Quasars
A novel method was developed to identify gravitationally lensed quasars, consisting of a morphological algorithm directed at finding wide-separation lens candidates and a point spread function (PSF)-difference-based algorithm aimed at identifying close-separation lens candidates.Janani N. Sivakumar, Pranav R. Sivakumar | May 1, 2015
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Investigating the Lymphotoxic Activity of an Ancient Fungal Pathogen of Amphibians
This research looked at how Batrachochytrium dendrobatidis, a fungal pathogen that infects amphibians, is able to suppress immune function.Camron Shirkhodaie, Laura K. Reinert, Louise A. Rollins-Smith | May 1, 2015
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Carbon and Oxygen Isotope Analysis to Document Childhood Diet and Local vs. Non-Local Status among African Slave Burials from the Grassmere Plantation, Nashville, Tennessee
Carbon and oxygen isotope analyses of human teeth from a captive slave population from the Grassmere Plantation in Nashville, Tennessee.Larisa DeSantis, Lindsey T. Yann, Molly K. Shea, Tiffiny A. Tung | April 30, 2015
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Development of a Two-Photon Lithography System
Development of a Two-Photon Lithography SystemJason Valentine, Susannah E. Price, Wei Li | April 29, 2015
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Experimental Validation of an Ion Simulation Model for Traveling Wave Ion Mobility Spectrometry
Experimental validation of theoretical results from a previously proposed traveling wave ion mobility model.Dheeraj S. Namburu, Jody C. May, John A. McLean | April 29, 2015
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Evaluation of Bigby Cannon Limestone’s Contributions to Pedogenesis Using Element Mass Flux Calculations
Bigby Cannon Limestone was analyzed to see if it contributes to soil development in Middle Tennessee.Dan Morgan, Jenna Nam, John Ayers, Nathan Katsiaficas, Xiaomei Wang | April 29, 2015
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Investigation of the Structure-Activity Relationship of a Dopamine Receptor 4 Antagonist to Treat Cocaine Addiction
This study demonstrates the successful synthesis of drug candidates for potential use as PET tracers and in vivo tool compounds to study and potentially treat cocaine addiction.Craig W. Lindsley, Cynthia G. Berry, Maylan D. Mehus | April 29, 2015
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Cell Shape Changes During Drosophila Germ Band Retraction: To-wards Model Validation by Experimental Comparison
This project seeks to experimentally validate simulated predictions of forces in a Drosophila embryo during germ band retraction.M. Shane Hutson, Monica E. Lacy, Xena McDonald | April 29, 2015
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The Effect of Trastuzumab, Paclitaxel, and XL147 Treatment on Aerobic Glycolysis in Breast Cancer Cells
This study evaluated the impact of select cancer treatments on the metabolic glucose consumption and lactate production of breast cancer cells.Joe T. Sharick, Melissa C. Skala, Re O. McClendon | April 29, 2015
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Development of an Enhanced Microfluidic Platform for Three-Dimensional Neuron Cell Culture
Here the development of a novel microfluidic device is described that enhanced media perfusion that can benefit neurons cultured in a three-dimensional matrix, attempting to model the in vivo microenvironment in the brain.Bryson M. Brewer, Deyu Li, John C.S. McCaw, Lijie Yang | April 29, 2015
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Analyzing Specific Health Hazards in Perfumes by Identifying Ingredients using Gas Chromatography- Mass Spectrometry
The ingredients in perfumes were identified using Gas Chromatography-Mass Spectrometry then analyzed for health hazards based on data provided on publically available Safety Data Sheets as well as standards set by the United Nations Globally Harmonized System of Classification and Labelling of Chemicals.Sarita D. Lee | April 29, 2015
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Activation of Silent Biosynthetic Pathways in Cave Microorganisms for Drug Discovery
Cave microorganisms were exposed to a variety of stimuli for the purpose of secondary metabolic pathway activation and potential acceleration of techniques for drug discovery.Alex S. Jolly, Brett C. Covington, Brian O. Bachmann, Dagmara K. Derewacz | April 29, 2015
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The Development of a Robot-Assisted Joint Attention Training System for Children with Autism
This research aims to help children with autism develop their social skills.Isaac Ige, Nilanjan Sarkar, Zhi Zheng | April 29, 2015
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Utilization of LEDs in a Communication Protocol for Endoscopic Submarine Capsules
A protocol for communication among a swarm of endoscopic submarine capsules was developed using light emitting diodes and color sensors.Charreau S. Bell, Nhung T. Hoang, Pietro Valdastri | April 29, 2015
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Characterization of Novel Drugs that Target the Hedgehog Signaling Pathway in Tumor Induced Bone Disease
This research presents information about optimized transfection conditions for MDA-MB- 231 cells, as well as cell viability data on known antagonists.Fenan Debesai, Julie Sterling, Ushashi Dadwal | April 29, 2015
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Investigating the Function of CTGF in β-Cell Mass and Glucose Tolerance During Pregnancy
CTGF is necessary for glucose tolerance during pregnancy, but overall β-cell mass is unchanged at the measured time-point.Maureen Gannon, Mounika Aramandla, Raymond C. Pasek | April 27, 2015