Thomas Scott

Crowdsourced Ligand Design for Selective Inhibition of the KNa1.2 (Slick) Potassium Channel implicated in Developmental Epileptic Encephalopathies

A hybrid strategy of small molecule drug design that combined evolutionary and crowd sourced designs yielded novel synthetically accessible candidate inhibitors of the Kna1.2 channel implicated in developmental epileptic encephalopathies.