The Institute for Space and Defense Electronics (ISDE) leads major research programs focused on radiation effects and radiation hardening of microelectronics for space, defense, and commercial applications. While ISDE manages several large-scale initiatives, our impact extends across a diverse network of over 50 partners, including commercial corporations and small businesses through SBIR and STTR collaborations. This broad engagement enables us to conduct fundamental research, apply engineering expertise, and develop radiation-hardened technologies that ensure reliable performance in extreme radiation environments. The following programs are a few of ISDE's largest on-going efforts.