Current Opportunities at Vanderbilt

Highly motivated candidates with a background in immunology are sought for a postdoctoral fellowship position in the lab of Dr. Janet Markle at Vanderbilt University Medical Center. The Markle Lab (www.marklelab.com) works at the interface of human genetics and immunology to understand how genetic mutations shape immune responses. We study monogenic inborn errors of immunity, which are severe diseases of the immune system (typically with onset in childhood) caused by rare, highly deleterious single-gene mutations. This patient-based research allows us to characterize the mechanisms of these patients’ diseases, and it is also a powerful way to understand fundamental principles of how the human immune system fights off pathogens and avoids self-harm. Our research includes i) finding new mutations through genome-wide sequencing of DNA from patients with severe immune-mediated diseases, ii) diverse molecular and cellular experiments to determine how these genetic mutations impact signaling and effector functions of immune cells, and iii) single-cell multi-omics approaches to understand how genetic variation shapes the immune system as a whole. The successful candidate will be self-motivated, work well with others, and enthusiastic about advancing patient-oriented research. Prior experience in the analysis of next-generation sequencing data is not required. The Markle lab will provide opportunities to learn new skills, work with a diverse team of clinicians and scientists, lead exciting projects, and share your work in conferences and publications. Vanderbilt University Medical Center (VUMC) provides an exceptional research environment with myriad seminar series, career development resources, top-notch core facilities, and opportunities for collaboration.

Specific degree and experience requirements include: Ph.D. in Biological Sciences (e.g., Immunology preferred, or Molecular/Cell Biology, Biochemistry, or Genetics). Experience with molecular/cell biology techniques, including cell culture, PCR, cloning, flow cytometry, western blot, ELISA, etc. Strong oral and written communication skills, with a publication record as first author in reputable journals. Ability to organize material for journal publications and grant submissions. Ability to help train graduate and undergraduate students, and work well in a multidisciplinary, collaborative environment. US citizens or residents interested in academic careers and/or desiring to apply for an NIH postdoctoral fellowship will be given special priority.

Salary: In accordance with NIH guidelines.
Schedule: This is a full-time position.
Location: Nashville, Tennessee.

Applications consisting of a cover letter, including a description of research experience, a complete curriculum vitae (including a complete list of publications), and contact information for three references should be submitted to Janet Markle at janet.markle@vumc.org.