Gene Mutation

A transcontinental research effort led by scientists from Vanderbilt University Medical Center and the University of Michigan has upended some long-standing assumptions about mutations — how often they occur, what causes them and what they do. Read More

Charles Sanders, PhD, and colleagues show how a “supertrafficking” mutant potassium channel contributes to heart rhythm abnormalities. Read More

A single mutation in one gene can impair inhibitory signaling in the brain and cause multiple types of seizures and behavioral abnormalities. Read More

The identification of a genetic culprit for hypoplastic left heart syndrome could lead to new treatments for the condition. Read More

A newly identified genetic risk factor for heart block after surgery may help guide the course of postoperative care. Read More

Researchers at Vanderbilt have identified what may be a genetic “smoking gun” for autism spectrum disorder (ASD) — a mutation in the gene for the critical neuronal protein CaMKII. Read More

Vanderbilt researchers developed a new algorithm to find clinically targetable gene rearrangements in cancers. Read More

A new report released this week raises questions about “gene drives,” a biological process that can profoundly and rapidly alter the characteristics of entire species. Read More

Using revolutionary CRISPR technology, Vanderbilt investigators have developed a fast and simple method to simultaneously turn off multiple genes in order to study complex diseases. Read More

Drugs developed at Vanderbilt could provide a new way to treat schizophrenia in a personalized way. Read More