F Guengerich
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Steroid binding to metabolic enzyme
Understanding how a steroid-metabolizing enzyme binds to its substrates may aid in designing drugs to treat sexual dysfunction as well as prostate cancer. Read MoreJune 12, 2019
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Faulty building blocks in DNA
An enzyme that builds DNA is able to insert the wrong building blocks, which could generate mutations. Read MoreJanuary 22, 2016
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Rational design of novel antifungals
Structural and molecular details of an anti-fungal target's interaction with inhibitors suggest ways to design better treatments for fungal infections. Read MoreOctober 7, 2015
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How the cell makes morphine
Vanderbilt investigators have discovered how mammals, including humans, produce the painkiller morphine. Read MoreAugust 25, 2015
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Bypassing DNA damage
Studies of a human polymerase that replicates DNA have provided a complete kinetic and structural framework for understanding how the enzyme accurately bypasses DNA damage. Read MoreMay 9, 2014
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Carcinogenic chemicals cramp DNA
Researchers have determined how a DNA lesion caused by exposure to chemicals may spark cancer formation. Read MoreNovember 21, 2012
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An orphan enzyme’s purpose
“Orphan” enzyme may play role in cancer growth, new research suggests. Read MoreOctober 4, 2012
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DNA: From modification to mutation
Understanding how an environmental hazard damages DNA may shed light on processes of tumor formation. Read MoreJune 8, 2012