DNA Replication

Vanderbilt investigators have generated a “parts list” for the molecular machinery that duplicates DNA each time a cell divides. The research has implications for cancer therapies that target components of this machinery. Read More

Vanderbilt and Stanford investigators have discovered how a protein that's part of the DNA replication "machinery" helps cells tolerate DNA damage. Read More

Insights into the workings of DNA damage response proteins such as SMARCAL1 could suggest new ways to improve genome integrity and prevent cancer. Read More

Studies of a human polymerase that replicates DNA have provided a complete kinetic and structural framework for understanding how the enzyme accurately bypasses DNA damage. Read More

David Cortez, Ph.D., and his Vanderbilt colleagues report new findings that shed light on fundamental processes involved in DNA replication and have implications for cancer therapies that target these processes. Read More

Structural studies reveal a new framework for understanding a central player in DNA processing. Read More

A new tool will allow researchers to identify proteins involved in DNA replication and damage repair, processes that go awry in cancer. Read More

I’ve always been fascinated, and occasionally frustrated, by the tendency of string, yarn, rope and wire – any thing that is long, thin and flexible – to knot and tangle. Fields Medal winner Vaughan F.R. Jones Clearly, I’m not the only one. Mathematicians have been studying knots… Read More