Cholesterol

A new model suggests that a protein involved in the generation of high-density lipoprotein (HDL) works differently than previously thought. Read More

Sean Davies and colleagues are exploring lipid aldehydes produced during oxidative stress and their contribution to HDL dysfunction and atherosclerosis. Read More

A single pill containing low doses of three medications to treat high blood pressure and one to lower cholesterol reduced the estimated risk of cardiovascular disease by 25%, according to a VUMC study. Read More

Lipid molecules that bind to HDL can modify its function — and blocking that modification can protect HDL and potentially lower the risk of atherosclerosis and heart disease. Read More

Vanderbilt investigators have discovered that oxidative damage may play an important role in the development of a rare cholesterol synthesis disease and in the behavioral changes of autism spectrum disorders. Read More

A zebrafish model of a rare genetic disease has revealed an unexpected regulatory pathway for cholesterol absorption and processing. Read More

Chronic kidney disease impairs the protective functions of HDL, Vanderbilt researchers report this month. Read More

A Vanderbilt University-led research team has discovered a “master regulator” for cholesterol production and transport in the liver — a tiny piece of RNA called microRNA-223. Read More

In some cases, HDL, the "good cholesterol," may not function properly and may actually accelerate atherosclerosis. Read More

The antioxidant vitamin E prevented the buildup of toxic products in a model of a rare genetic disorder, suggesting new strategies for therapeutic development. Read More