Beta Cells
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Beta cell regeneration
Vanderbilt researchers dissected the complex microenvironment of the pancreatic islet to discover the signals that drive beta cell regeneration — as a possible treatment for diabetes. Read MoreMay 20, 2021
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Keeping beta cells “fit”
Vanderbilt cell biologists are defining the factors that help beta cells in the pancreas stay healthy, secrete insulin and prevent diabetes initiation and progression. Read MoreJuly 9, 2020
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Cellular calcium handling in diabetes
Potassium channels in a cellular organelle regulate calcium flux and appear to play a critical role in pancreatic beta cell health. Read MoreSeptember 28, 2017
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Therapeutic targets for diabetes
Vanderbilt investigators have identified novel regulators of insulin-producing beta-cell proliferation and survival, suggesting new targets for the treatment of type 2 diabetes. Read MoreMay 3, 2017
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Making human beta cells reproduce
A new method developed at Vanderbilt will speed the search for potential therapeutics for diabetes: compounds that stimulate the replication of insulin-producing beta cells. Read MoreDecember 8, 2016
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Fighting type 2 diabetes with FGF1
The growth factor FGF1 induces the growth of new insulin-producing beta cells and may help treat type 2 diabetes. Read MoreNovember 18, 2015
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New therapeutic target for diabetes
The factor FoxM1 increases the proliferation and function of insulin-producing beta cells, making it an attractive therapeutic target for diabetes. Read MoreAugust 20, 2015
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Boosting beta cells in diabetes
New findings suggest that it might be possible to treat diabetes by regenerating insulin-producing beta cells in the pancreas. Read MoreApril 20, 2015
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CaMKII enhances insulin secretion
The protein CaMKII acts as a calcium sensor in a positive feedback pathway that enhances glucose-stimulated insulin secretion. Read MoreMay 14, 2014
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Searching for beta cell stimulators
Vanderbilt researchers describe a new technique for identifying factors that stimulate the proliferation of pancreatic beta cells – factors that might offer therapeutic options for diabetes. Read MoreJanuary 13, 2014