Simulating Deep Brain Stimulation for Optimal Therapeutic Planning
The use of deep brain stimulation (DBS) for the treatment of neurological motor degenerative disorders involves the precise placement of the stimulating electrode placement and the determination of optimal stimulation parameters that optimally reduce symptoms (e.g. tremor, rigidity, movement difficulties, etc.) while minimizing undesired physiological side-effects. This project is investigating the feasibility of determining the ideal electrode placement and amplitude by performing a patient-specific multivariate optimization using electrophysiological atlases and bioelectric finite element model of the brain.