VISE Spring Seminar – Muneeb Ahmed, MD – postponed
VISE Spring Seminar has been postponed.
to be led by
Muneeb Ahmed, MD
Chief, Vascular and Interventional Radiology,
Vice Chair for Interventional Services|Radiology,
Beth Israel Deaconess Medical Center
Associate Professor of Radiology|Harvard Medical School
Date: Thursday, March 12, 2020
Time: 12:15 pm lunch, 12:25 pm start
Location: Stevenson 5326
Title: Systemic implications of locoregional therapies: Lessons learned from tumor ablation
Abstract: Minimally-invasive, image-guided tumor ablation (using extreme heat or cold or mechanical injury) is now in widespread clinical use to treat a wide range of focal primary and metastatic tumors in the liver, kidney, and lung. Tumor ablation induces a number of local tissue reactions in and surrounding the ablation zone from changes in tissue perfusion and upregulation of pathways linked to tissue injury and inflammation. Increasingly, there is also evidence that a number of tissue and cellular interactions taking place locally in the ablated tissue also lead to systemic activation of pathways linked to anti-tumor immunity or inflammation-mediated distant tumor stimulation. In this lecture, we will discuss the current state of knowledge with regard to local reactions induced by tumor ablation therapies, how these may vary based on the type of ablation used, the types of downstream systemic effects that occur following local ablation, and how such effects can be modulated through the use of adjuvant targeted drug therapies. Finally, future areas of study, including combining ablation with targeted drug delivery to modulate the tumor microenvironment, will be discussed.
Short Bio: Dr. Muneeb Ahmed, MD FSIR, is Chief of the Division of Interventional Radiology and a Vice-Chair of Radiology at Beth Israel Deaconess Medical Center and an Associate Professor at Harvard Medical School. His primary clinical and research interests are in Interventional Radiology treatments for cancer and in image-guided tumor ablation. Following completion of medical school at the Aga Khan University in Pakistan, he began his career in radiology as an NCI-funded cancer radiology research fellow at BIDMC. Upon completing radiology residency training (also at BIDMC) and a clinical IR fellowship at The Johns Hopkins Hospital, he returned to BIDMC as faculty, where he has continued to pursue his clinical and research interests in image-guided cancer therapies. Dr. Ahmed directs the NIH-funded Minimally-Invasive Tumor Therapy Laboratory, where his team studies tumor ablation biology, targeted drug delivery, and systemic effects of locoregional cancer therapies. On the basis of this work, he received the SIR’s Gary J. Becker Young Investigator Award in 2014, and was named a Fellow of the Society of Interventional Radiology in 2015. To date, he has co-authored over 85 original research articles and over 35 invited reviews and book chapters in interventional radiology, and given numerous invited lectures.