VISE Fall Seminar September 10- Muneeb Ahmed, MD
VISE Fall Seminar
to be led by
Muneeb Ahmed, MD
Chief, Vascular and Interventional Radiology
Vice Chair for Interventional Services|Radiology
Beth Israel Deaconess Medical Center
Associate Professor of Radiology| Harvard Medical School
Date: Thursday, September 10, 2020
Time: 12:15 p.m. room admittance, 12:25 p.m. (Zoom details will go out in the morning of the 10th)
Title: “Systemic implications of locoregional therapies: Lessons learned from tumor ablation”
Abstract: Minimally-invasive, image-guided tumor ablation (using extreme heat or cold or mechanical injury) is now in widespread clinical use to treat a wide range of focal primary and metastatic tumors in the liver, kidney, and lung. Tumor ablation induces a number of local tissue reactions in and surrounding the ablation zone from changes in tissue perfusion and upregulation of pathways linked to tissue injury and inflammation. Increasingly, there is also evidence that a number of tissue and cellular interactions taking place locally in the ablated tissue also lead to systemic activation of pathways linked to anti-tumor immunity or inflammation-mediated distant tumor stimulation. In this lecture, we will discuss the current state of knowledge with regard to local reactions induced by tumor ablation therapies, how these may vary based on the type of ablation used, the types of downstream systemic effects that occur following local ablation, and how such effects can be modulated through the use of adjuvant targeted drug therapies. Finally, future areas of study, including combining ablation with targeted drug delivery to modulate the tumor microenvironment, will be discussed.