Spring Seminar – Lori Jordan, MD
VISE Spring Seminar
to be led by
Lori Jordan, M.D., Ph.D.,
Associate Professor of Pediatrics and Neurology,
Director, Pediatric Stroke Program,
Vanderbilt University Medical Center
Date: Thursday, March 15, 2018
Location: Stevenson Center 5326
Time: 12:25 p.m. start, 12:15 p.m. lunch
“Sickle Cell Disease, Cerebral Hemodynamics, and Stroke”
Children and adults with sickle cell anemia (SCA) have a higher risk of strokes compared to age- and race-matched peers. Velocity in the middle cerebral or distal internal carotid artery as measured by transcranial Doppler ultrasound is a recognized method to identify children but not adults with SCA at high-risk for first stroke. For both children and adults with SCA that have had a stroke, no methods clearly identify individuals at highest risk of recurrent strokes or an initial silent cerebral infarct, the most common neurological injury. Methods to assess cerebral hemodynamics in SCA have been utilized for decades but often required radiotracers making them not feasible for screening and longitudinal follow-up. MRI approaches that do not require exogenous contrast have been introduced and are appealing in both clinical and research scenarios. Improved neuroimaging strategies hold promise for identifying individuals with SCA at increased risk of initial and recurrent infarcts, justifying more aggressive risk-based therapy. We will discuss the impact of strokes, stroke mechanisms, and potential new cerebral imaging and monitoring strategies including regional and global oxygen extraction fraction, cerebral blood flow, and vessel wall imaging to identify individuals at highest risk of initial stroke and stroke recurrence.
Lori Jordan, MD, PhD is an Associate Professor of Pediatrics and Neurology at Vanderbilt University Medical Center in Nashville, TN. She completed medical school at the University of Oklahoma and residency in Pediatrics and Child Neurology at the Johns Hopkins Hospital in Baltimore. Dr. Jordan became interested in stroke in children and young adults during her child neurology residency. She completed a fellowship in vascular neurology (stroke) at Johns Hopkins as well as a PhD in Clinical Investigation at the Johns Hopkins Bloomberg School of Public Health. At Vanderbilt, Dr. Jordan directs the child neurology residency program and the pediatric stroke program. She developed an acute stroke team for children at Monroe Carell Jr. Children’s Hospital. Dr. Jordan’s research is focused on understanding predictors of recovery after stroke in children and on primary and secondary stroke prevention in children and young adults with sickle cell anemia. She has research funding from the American Heart Association and the National Institutes of Health.