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Craig L. Duvall

Associate Professor of Biomedical Engineering

Research:

The Duvall Advanced Therapeutics Laboratory specializes in innovative design of smart polymer-based technologies for: (1) intracellular delivery of biological drugs such as peptides and nucleic acids, (2) proximity-activated targeting of drugs to sites of inflammation and matrix remodeling, and (3) long-term, “on-demand” drug release from localized depots. These delivery systems are designed to improve the therapeutic index of existing drugs and/or to serve as enabling technologies for manipulation of intracellular targets currently considered to be “undruggable”. To achieve finely-tuned control of drug delivery, polymers are designed and synthesized that respond to one or more environmental stimuli including pH, matrix metalloproteinases, reactive oxygen species, and temperature. We focus development of these technologies toward regenerative medicine applications such as improving vascular bypass transplants, promoting vascularization and survival of cell and tissue engineering therapies, improving limb survival and recovery following ischemic/oxidative injury, and blocking progression of degenerative diseases such as osteoarthritis.

Awards:

Society for Biomaterials Young Investigator Award, 2015
NSF CAREER Award, 2014
Controlled Release Society Best Paper Award, 2012 and 2014
American Heart Association Scientist Development Award, 2011
NIH Ruth L. Kirschstein National Research Service Award Postdoctoral Fellowship, 2008
National Science Foundation Graduate Research Fellowship, 2003

Selected Publications:

Fluorocoxib A loaded nanoparticles enable targeted visualization of cyclooxygenase-2 in inflammation and cancer. Uddin, MJ; Werfel, TA; Crews, BC; Gupta, MK; Kavanaugh, TE; Kingsley, PJ; Boyd, K; Marnett, LJ; Duvall, CL, BIOMATERIALS, 92, 71-80 , (2016) View Abstract

Porous Silicon and Polymer Nanocomposites for Delivery of Peptide Nucleic Acids as Anti-MicroRNA Therapies. Beavers, Kelsey R.; Werfel, Thomas A.; Shen, Tianwei; Kavanaugh, Taylor E.; Kilchrist, Kameron V.; Mares, Jeremy, W.; Fain, Joshua S.; Wiese, Carrie B.; Vickers, Kasey C.; Weiss, Sharon M.; Duvall, Craig L., Advanced Materials, , , (2016) View Abstract

MK2 inhibitory peptide delivered in nanopolyplexes prevents vascular graft intimal hyperplasia. Evans, BC; Hocking, KM; Osgood, MJ; Voskresensky, I; Dmowska, J; Kilchrist, KV; Brophy, CM; Duvall, CL, SCIENCE TRANSLATIONAL MEDICINE, 7, 291ra95 , (2015) View Abstract

Cell Protective, ABC Triblock Polymer-Based Thermoresponsive Hydrogels with ROS-Triggered Degradation and Drug Release. Gupta, MK; Martin, JR; Werfel, TA; Shen, TW; Page, JM; Duvall, CL, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 136, 14896-14902 , (2014) View Abstract

Balancing Cationic and Hydrophobic Content of PEGylated siRNA Polyplexes Enhances Endosome Escape, Stability, Blood Circulation Time, and Bioactivity in Vivo. Nelson, CE; Kintzing, JR; Hanna, A; Shannon, JM; Gupta, MK; Duvall, CL, ACS NANO, 7, 8870-8880 , (2013) View Abstract