Vanderbilt Institute of Chemical Biology

 

 

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VICB 2019-2020 Seminar Schedule

 

 

Fall 2019
Seminar Schedule


Jennifer Prescher

UNiversity of California - Irvine

 

"Bioluminescent probes to spy on cellular communication"

 

Wednesday, September 4, 2019

12:15 P.M. — 1:15 P.M.

1220 MRB III

 

Research Summary

Our research team is crafting novel probes to "spy" on cells and decipher their communications in vivo. We are designing and deploying custom tools to visualize cellular networks in real time—and with molecular precision—in physiologically relevant environments. Collectively, our work is decoding cellular communications relevant to infectious disease, cancer metastases, and immune function.

Craig Duvall

Vanderbilt univerity

 

"Intracellular Acting Biologic Nano and Molecular Therapies"

 

Wednesday, September 11, 2019

12:15 P.M. — 1:15 P.M.

1220 MRB III

 

Key Lecture Points

 

Mike Villalobos

Vanderbilt univerity CTTC

 

"Understanding Licensing Revenue Distribution & the Impact of IP Policies"

 

Wednesday, September 25, 2019

12:15 P.M. — 1:15 P.M.

1220 MRB III

 

Key Lecture Points

  • Factors impacting distributions
  • VU's IP policy
  • Who can participate?
  • Documenting revenue sharing
  • Revenue distribution policies
  • Impact of future inventions

 

Bradley Moore

univerity of california - San Diego

 

"Connecting genes to chemistry to empower natural product drug discovery and biocatalysis"

 

Wednesday, October 2, 2019

12:15 P.M. — 1:15 P.M.

1220 MRB III

 

Key Lecture Points

  • Biosynthesis
  • Genome mining
  • Natural products

Jeremy Baskin

Cornell university

 

"Chemical tools that IMPACT lipid signaling"

 

Wednesday, October 9, 2019

12:15 P.M. — 1:15 P.M.

1220 MRB III

 

Key Lecture Points

  • Phospholipid signaling/phosphatidic acid/phospholipase D
  • Bioorthogonal chemistry/click chemistry
  • Imaging of phospholipid transport

Jason Gestwicki

univerity of california - San francisco

 

"Pharmacological Chaperones to Treat Protein Misfolding Diseases"

 

Wednesday, October 16, 2019

12:15 P.M. — 1:15 P.M.

1220 MRB III

 

Key Lecture Points

  • Many diseases, including cataract, are caused by protein misfolding and aggregation.
  • We have developed methods to identify drug-like small molecules that bind and stabilize damaged proteins (termed correctors).
  • New methods in high throughput differential scanning fluorometry (HT-DSF) show promise as a robust way to discover additional correctors.

 

 

Drew Adams

case western University

 

"Accumulation of 8,9-unsaturated Sterols as a Unifying Mechanism for Drug Induced Remyelination"

 

Wednesday, October 30, 2019

12:15 P.M. — 1:15 P.M.

1220 MRB III

 

Key Lecture Points

 

Arjun Raj

university of pennsylvania

 

"Time Machines, CRISPR Screens, and Therapy Resistance in Cancer"

 

Wednesday, November 6, 2019

12:15 P.M. — 1:15 P.M.

1220 MRB III

 

Key Lecture Points

Cancer is a disease that originates from single cells, and the treatment of cancer also is a problem of single cells: anti-cancer therapies can often kill the vast majority of tumor cells but a few rare cells remain and grow despite treatment. Often, it is thought that the underlying basis for the behavior of these rare cells is a genetic difference. However, we and others have shown that non-genetic differences may be a key driver of rare, drug resistant cells, yet the precise molecular nature of these differences often remains mysterious. We describe the development of a cellular "time machine" that allows us to link the ultimate cellular fate to the initial cellular state on a single cell basis, thus revealing markers for pre-resistant cells in the population. Further, we use genetic screening technologies to elucidate the pathways that control the formation of these rare cells and discuss their therapeutic implications.

 

 

Eric Strieter

university of massachusetts

 

"Uncovering the Cryptic Functions of Deubiquitinases"

 

Wednesday, November 13, 2019

12:15 P.M. — 1:15 P.M.

1220 MRB III

 

Key Lecture Points

  • Chemical and analytical tools enable thecharacterization of complex ubiquitin chainarchitectures
  • Deubiquitinases are sensitive to subtle changesin ubiquitin chain architecture
  • Removal of branch points within ubiquitinchains alters the fate of the modified protein

 

Stephen Kent

university of Chicago

 

"Through the Looking Glass – a New World of Proteins Enabled by Chemistry"

 

Wednesday, November 20, 2019

12:15 P.M. — 1:15 P.M.

1220 MRB III

 

 

 

Barbara Imperiali

massachusetts institute of technology

 

"Protein Glycosylation Pathways and Processes"

 

Wednesday, December 11, 2019

12:15 P.M. — 1:15 P.M.

1220 MRB III

 

Key Lecture Points 

  • Many glycan biosynthesis pathways arestrategically located at membrane interfaces
  • Chemical biology approaches provide powerfulopportunities for studying membrane-associatedpathways in model membrane environments.
  • Membrane-bound enzymes have evolved to negotiatesoluble and hydrophobic substrates
Winter-Spring 2020
Seminar Schedule

Nicole Sampson

Stony Brook university

 

"Tuberculosis Drug Discovery and Diagnosis Targeting Cholesterol Pathways"

 

Wednesday, January 15, 2020

12:15 P.M. — 1:15 P.M.

1220 MRB III

 

Key Lecture Points 

  • Cholesterol metabolism is one of the mechanisms bywhich mycobacteria, e.g., Mycobacteriumtuberculosis (Mtb), survive and persist in theirhuman host.
  • An investigation of the entire cholesterolmetabolism pathway in Mtb using a multi-prongedapproach that includes elucidating enzymefunction, establishing metabolite structure andactivity has led to the identification of smallmolecules that interfere with the survival of Mtbin the human host.
  • The lead compounds target a cholesterol-dependentpersistence pathway, and the mechanism isdistinct from current TB drugs on the market orin development. Current work is focused onfurther elucidating the mechanism of action.

 

Eric Brown

McMaster university

 

"A Path of Ceased Resistance: Systems Approaches to Antibiotic Drug Discovery"

 

Wednesday, January 22, 2020

12:15 P.M. — 1:15 P.M.

1220 MRB III

 

Key Lecture Points

  • Modern target-focused antibacterial drug discoveryhas failed to deliver new antibacterial drugs.
  • The Brown lab is developing new technology tochart genetic and chemical interactions on agenome-scale.
  • These approaches are facilitating discoveryefforts targeting the cell surface and nutrientstress in bacteria.

Rachel Haurwitz

caribou biosciences

 

"The Future Is Allogeneic - Translating a CRISPR Platform Into Gene-Edited Cell Therapies"

 

Wednesday, February 5, 2020

12:15 P.M. — 1:15 P.M.

1220 MRB III

 

Key Lecture Points 

  • Caribou has developed CRISPR guides including DNA nucleotides (CRISPR hybrid RNA-DNA, or chRDNA) that significantly improve the specificity of Cas9- and Cas12a-mediated genome editing
  • Caribou has harnessed Cascade complexes from Type I CRISPR systems to edit human cells using either a CRISPR enzyme (Cas3) or a restriction enzyme (FokI)
  • Using the chRDNA technologies, Caribou is developing off-the-shelf gene-edited CAR-T therapies to treat a variety of tumors and has demonstrated in vitro and in vivo efficacy targeting human models of ALL, MCL, and DLBCL

 

Vito Quaranta

vanderbilt university

 

"Systems-Level Approaches to Cancer Heterogeneity: Phenotypic Landscapes, Trajectories and Destabilizers"

 

Wednesday, February 12, 2020

12:15 P.M. — 1:15 P.M.

1220 MRB III

 

Key Lecture Points 

Niyi Fadeyi

merck

 

"Understanding Immune Cell Interactions via Photocatalysis"

 

Wednesday, February 26, 2020

12:15 P.M. — 1:15 P.M.

1220 MRB III

 

Key Lecture Points 

  • Cellular Chemistry
  • Chemical Biology
  • Drug Discovery

Scott Thacher

orphagen pharmaceuticals

 

"TITLE TBA"

 

Wednesday, March 11, 2020

12:15 P.M. — 1:15 P.M.

1220 MRB III

 

Key Lecture Points 

Chuan He

university of chicago

 

"TITLE TBA"

 

Wednesday, March 18, 2020

12:15 P.M. — 1:15 P.M.

1220 MRB III

 

Key Lecture Points 

Victor Darley-Usmar

university of Alabama At BirminghaM

 

"TITLE TBA"

 

Wednesday, April 1, 2020

12:15 P.M. — 1:15 P.M.

1220 MRB III

 

Key Lecture Points 

Joseph Loo

university of california - los angeles

 

"TITLE TBA"

 

Wednesday, April 8, 2020

12:15 P.M. — 1:15 P.M.

1220 MRB III

 

Key Lecture Points 

Justin Du Bois

stanford university

 

"TITLE TBA"

 

Wednesday, April 15, 2020

12:15 P.M. — 1:15 P.M.

1220 MRB III

 

Key Lecture Points 

 

   

 

Other Seminars of Interest

 

 

Chemistry Seminar Schedule

Pharmacology Seminar Schedule

 

Department of Biochemistry Seminar Schedule

 

Student Research Symposia

 

2019 Symposium - Archive

 

2018 Symposium - Archive

 

2017 Symposium - Archive

 

2016 Symposium - Archive

 

2015 Symposium - Archive

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