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Position Detail

Postdoctoral Position in structural mechanisms of signaling molecules.

School of Medicine Basic Sciences

The Kuriyan lab at Vanderbilt University is seeking a creative, motivated, and highly skilled Postdoctoral Scholar to join a project aimed at understanding tyrosine kinases and signaling pathways in mammalian cells. The proteins involved include, but are not limited to, the tyrosine kinases BCR-Abl, ZAP-70, Syk, BTK and ITK, and proteins involved in Ras signaling. The lab uses high-throughput mutagenesis strategies combined with structure-based reasoning to advance our understanding of these molecules, with a particular emphasis on drug-resistance mutations.

The ideal candidate will demonstrate a high level of expertise in E.coli or mammalian expression and purification of proteins. Experience with reconstitution of proteins in a supported lipid bilayer would be a plus. Deep mutational scanning to analyze protein structure and function will play a major role in the research and experience with DNA library cloning strategies, or at minimum DNA manipulation strategies, along with experience with next generation sequencing would be preferred. Skill in analytical biochemistry and experience with, or strong interest in, protein structure and the dissection of structural mechanisms will be an asset. Experience with CryoEM to determine protein structures would also be a plus.

Vanderbilt University is an Equal Opportunity Employer.

Interested candidates should email a single PDF with a cover letter, CV, and names of three references to anne.b.lara@vanderbilt.edu and include “Kuriyan lab postdoc application” in the subject of the email.

Only correspondence to the designated email address will be considered, and unfortunately, due to the number of applications we receive, we may not be able to reply individually to all inquiries.

Anne Lara
: anne.b.lara@Vanderbilt.Edu
: (615) 322-0907
2022-11-14 20:12:17

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