The Ayala lab is seeking a post-doctoral fellow interested in mechanisms regulating feeding behavior and body weight. Research in the lab focuses on mechanisms by which the incretin hormone Glucagon-like peptide-1 (Glp1) and Glp1 receptor (Glp1r) agonists target the central nervous system to regulate caloric intake, feeding behavior, and body weight. We approach this using state-of-the-art techniques at the intersection between whole-body physiology, metabolism, and neuroscience in mouse models. Techniques to which you will be exposed include metabolic phenotyping, DREADD/optogenetics, fiber photometry, behavioral analyses. Current projects include: 1. Investigation of molecular mechanisms in the hypothalamus targeted by Glp1r agonists to reduce food intake/body weight. 2. Interrogating how Glp1r agonists and Fibroblast Growth Factor-21 (FGF21) regulate carbohydrate consumption. 3. Investigating the role of Glp1 producing neurons in the brainstem in the regulation of feeding behavior in response to metabolic and psychogenic stressors.
|Molecular Physiology & Biophysics|
We are looking for a highly motivated individual with expertise in metabolism and/or neuroscience. The Ayala is a diverse group and working in the lab provides an opportunity for interactions with a variety of different collaborators.
: (615) 343-7252