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Position Detail

Postdoctoral Position in the Laboratory of Dr. Sergey Dikalov in the Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN. Dr. Sergey Dikalov laboratory is seeking a postdoctoral fellow to perform research related to the role of vascular cyclophilin D (CypD) and therapeutic potential of targeting CypD in vascular dysfunction and hypertension. The position offers a highly competitive NIH Postdoctoral level salary, benefits, an outstanding research environment here at Vanderbilt University Medical Center (VUMC). The candidate must hold a Ph.D. or equivalent in molecular biology, physiology or related fields, and have first author publications in peer reviewed journals. Qualified applicants will be motivated individuals with a background in vascular biology and hypertension, and able to work independently. Prospective candidates will be trained in areas including oxidative stress, mitochondrial biology, Electron Spin Resonance spectroscopy, redox and metabolic signaling pathways. The position will initially be for two year funded by a NIH RO1 grant with the potential for extending it up to 4 years.

Medicine

Postdoctoral Position in the Laboratory of Dr. Sergey Dikalov in the Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN. 

Dr. Sergey Dikalov laboratory is seeking a postdoctoral fellow to perform research related to the role of vascular cyclophilin D (CypD) and therapeutic potential of targeting CypD in vascular dysfunction and hypertension. 

The position offers a highly competitive NIH Postdoctoral level salary, benefits, an outstanding research environment here at Vanderbilt University Medical Center (VUMC). The candidate must hold a Ph.D. or equivalent in molecular biology, physiology or related fields, and have first author publications in peer reviewed journals. Qualified applicants will be motivated individuals with a background in vascular biology and hypertension, and able to work independently.
Prospective candidates will be trained in areas including oxidative stress, mitochondrial biology, Electron Spin Resonance spectroscopy, redox and metabolic signaling pathways.
The position will initially be for two year funded by a NIH RO1 grant with the potential for extending it up to 4 years.

Key responsibilities include:
• Designing and conducting mouse studies using DOCA-salt and angiotensin II models of hypertension, performing mouse surgeries for telemetry placement and osmotic minipumps, telemetry studies in animal models, isolation of aortas and mesenteric arteries, analysis of endothelial dependent and endothelium-independent relaxation.
• Cell and tissue culture, cell isolation/purification, flow cytometry and immunohistochemistry. Analysis of vascular hypertrophy, vascular oxidative stress and cell signaling pathways. 
• Studies of mitochondrial function and mPTP opening in intact cells, vascular tissue and isolated mitochondria. Analysis of CypD post-translational modifications in mouse and human vascular tissue using Western blot and mass spectrometry to define specific role of CypD acetylation in endothelial and smooth muscle cells using mouse and cellular models.
• Contribution to ongoing clinical collaborative project to target CypD in human vascular tissues isolated from normotensive and hypertensive subjects.
• Preparation of research manuscripts (original manuscripts with research data or reviews) and research reports related to your projects.
• Preparation and submission of abstracts and participation in conferences in the area of biomedical sciences (one conference per year will be covered by your supervisor).
• Participating in the preparation and submission of research and fellowship grant applications.
• Work with mentor and other lab personnel in project implementation, data collection and analyses, writing manuscripts and grant applications.

Please send CV and contact information of three references to Dr. Sergey Dikalov at sergey.dikalov@vumc.org. VUMC is an equal opportunity employer.

Sergey Dikalov, PhD, FAHA
Associate Professor
Division of Clinical Pharmacology
Department of Medicine
Vanderbilt University Medical Center
Nashville, TN

https://pubmed.ncbi.nlm.nih.gov/?term=Dikalov+S&sort=date

Please send CV and contact information of three references to Dr. Sergey Dikalov at sergey.dikalov@vumc.org. VUMC is an equal opportunity employer.

Sergey Dikalov, PhD, FAHA
Associate Professor
Division of Clinical Pharmacology
Department of Medicine
Vanderbilt University Medical Center
Nashville, TN

Sergey Dikalov
: sergey.dikalov@vumc.org
: (615) 936-3694
2021-04-16 13:00:35

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