Postdoctoral research fellow will work in cell models and animal models to study the underlying molecular regulators of vascular disease, both in the context of atherosclerosis and aging.
| Cardiovascular Medicine | |
The Brown Laboratory studies how chromatin-dependent signaling controls pathologic gene expression in cardiometabolic diseases. In particular, our group focuses on how BET bromodomain-containing “reader” proteins regulate transcription in response to stress signals in endothelial cells, vascular smooth muscle cells and macrophages. We have discovered that selective inhibition of BETs can reduce atherosclerosis in murine models of disease. These data demonstrate a novel therapeutic approach to drug pathologic transcription by targeting specific chromatin-associated coactivator proteins. More recently, we have used genome-wide maps of chromatin coactivator occupancy coupled with gene expression profiles to predict gene regulatory circuits that drive changes in cell state in cardiovascular disease. |
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Please send your curriculum vitae to Jonathan D. Brown along with the names and contact information for at least 1 reference. |
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| Jonathan Brown : jonathan.d.brown@vumc.org : (615) 936-1556 |
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| 2021-01-13 18:12:32 |