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Position Detail

Postdoctoral research fellow will work in cell models and animal models to study the underlying molecular regulators of vascular disease, both in the context of atherosclerosis and aging.

Cardiovascular Medicine

The Brown Laboratory studies how chromatin-dependent signaling controls pathologic gene expression in cardiometabolic diseases. In particular, our group focuses on how BET bromodomain-containing “reader” proteins regulate transcription in response to stress signals in endothelial cells, vascular smooth muscle cells and macrophages. We have discovered that selective inhibition of BETs can reduce atherosclerosis in murine models of disease. These data demonstrate a novel therapeutic approach to drug pathologic transcription by targeting specific chromatin-associated coactivator proteins. More recently, we have used genome-wide maps of chromatin coactivator occupancy coupled with gene expression profiles to predict gene regulatory circuits that drive changes in cell state in cardiovascular disease.

Our group is seeking a highly motivated postdoctoral research fellow who can leverage cell biology approaches and murine models of disease to study how cell-type specific gene activation is controlled during atherosclerosis. Cutting-edge next-generation sequencing (NGS) assays including single-cell RNA-seq, ChIP-seq and ATAC-seq will be used to define the gene regulatory circuits activated during initiation and progression of vascular disease in the context of atherosclerosis and aging. Ultimately, the goal of this work is to discover and experimentally validate previously unidentified transcriptional regulators involved in vascular disease.

Job Requirements:
• Ph.D. or M.D./Ph.D. in gene regulation, molecular biology, vascular biology or related field.
• Working skills in standard laboratory techniques including PCR, cloning and cell culture.
• Experience with Next-Generation Sequencing assays and NGS data analysis is encouraged.
• Experience working with mice is encouraged.
• Ability to work independently.
• Minimum 2-year commitment.

Please send your curriculum vitae to Jonathan D. Brown along with the names and contact information for at least 1 reference.

Jonathan Brown
: jonathan.d.brown@vumc.org
: (615) 936-1556
2021-01-13 12:12:32

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