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Postdoctoral fellow/research associate positions available in epithelial cell biology and pathobiology

Epithelial Biology Center

Research in a multiply NIH-funded program to investigate the roles of Rab11 interacting proteins and class V myosin motors (MYO5B) in regulating membrane trafficking in polarized intestinal epithelial cells. Investigations also seek to characterize trafficking deficits in congenital diarrhea syndromes and develop to develop therapeutic strategies for overcoming deficits in apical membrane trafficking.

Projects available include:
• Trafficking defects in MYO5B KO mice and enteroids and therapeutic approaches to ameliorating diarrhea in Microvillus Inclusion Disease (MVID). 
• Identification of trafficking pathways responsible for diarrhea in infants with loss of DGAT1.
• Characterization of apical bulk endocytosis in MYO5B KO neonatal enterocytes.
• Identification of the roles Rab11-FIP1 and Rab11-FIP2 as regulators of junctions and polarity, including the characterization of novel KO mouse models and the evaluation of recently identified biding proteins. 
• Characterization of apical trafficking deficits in the intestines of patients with congenital diarrhea of unknown origin with genomic analysis and development of enteroids from patients.

These studies include a range of cell biological techniques including 3-dimensional and 2-dimensional enteroid cultures, live cell microscopy, confocal fluorescence microscopy, high throughput chemical library and siRNA library screening, whole exome sequencing analysis, and single cell RNA sequencing analysis. 

Candidates should have a MD and/or PhD degree with experience in cellular physiology and/or cellular biology.

Applicants should send CV and references to James Goldenring, MD, PhD, Epithelial Biology Center, MRB4 Rm. 10435G, Vanderbilt University School of Medicine, 2213 Garland Avenue, Nashville, TN 37232.

James Goldenring, MD, PhD
: jim.goldenring@vumc.org
: (615) 936-3726
2020-09-01 11:27:40

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