Postdoctoral position in a Cancer Biology Laboratory working in cell signaling, transcriptional regulation, host-tumor interactions, and inflammatory regulation in GI tract cancers.
Surgical Sciences | |
A postdoctoral research position is available in the laboratory jointly led by Drs. Anna Means and R. Daniel Beauchamp. The lab is focused on the biology of GI tract cancers, primarily colorectal cancer and the molecular events and host-tumor interactions that result in tumor initiation, tumor progression and metastasis. Our most recent work has identified an important role for TGF-beta canonical signaling through SMAD4 in controlling intestinal epithelial cell inflammatory responses, linking the tumor suppressor role of SMAD4 to its anti-inflammatory function. Ongoing work in this project seeks to determine the biochemical and molecular mechanisms involved in this regulation with the goal of identifying potential biomarkers and therapeutic targets to improve the treatment of GI tract malignancies. The lab utilizes multiple complementary approaches to these biological questions that include organoid cell culture, mouse models of cancer, human tissue studies, immunophenotyping, biochemical analyses, comprehensive NGS omics analyses including single cell analyses, ChIPseq, ATACseq and computational biology. Our research is generously supported by endowment funds and NIH grant funding. |
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Please contact Robert Daniel Beauchamp, MD, and/or Anna L. Means, PhD, to apply for this position.
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R. Daniel Beauchamp, MD : daniel.beauchamp@vumc.org : (615) 322-2363 |
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2019-03-19 17:54:33 |