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Position Detail

Research in a multiply-funded, multidisciplinary program to investigate the origin and progression of precancerous metaplasia in the stomach. Research is focused on questions of identity and function of pre-cancerous stem cells and the relationship of intrinsic and extrinsic immune cells as well as stromal cells to influence their progressive intestinalization and evolution to cancer.

Section of Surgical Sciences

Projects available:
• Characterization of metaplastic organoids from both mouse models and humans.
• Single cell analysis of stem cell populations with metaplastic populations.
• Evaluation of MEK inhibitor treatment on the behavior of normal and metaplastic stem cell populations.
• Evaluation of markers of metaplastic progression towards cancer.
• Investigation of intracellular regulators of chief cell transdifferentiation into metaplasia.
• Evaluation of the role of intrinsic immune cell populations in the stomach in induction and progression of metaplasia.

These studies include a range of cell biological techniques including 3-dimensional organoid culture, live cell microscopy, confocal fluorescence microscopy, single cell RNA sequencing, and multiplex fluorescence imaging and analysis.

Send CV and references to James Goldenring, MD, PhD, Epithelial Biology Center, MRB4 Rm. 10435G, Vanderbilt University School of Medicine, 2213 Garland Avenue, Nashville, TN 37232.

Jim Goldenring, MD, PhD
2018-10-12 16:49:34

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