VUMC Postdoc position (starting January 2019) to investigate the significance of cardiac ion channel variants to the individuals who carry them
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The Kroncke laboratory aims to address the challenge of variants of uncertain significance (VUSs) in cardiac ion channels by blending experimental and computational strategies: 1) determine structure and flexibility-induced changes from selected ion channel variants using a combination of Rosetta modeling, molecular dynamics in AMBER, and nuclear magnetic resonance (NMR). 2) generate experimental deep mutational scanning data sensitive to trafficking/functionally defective ion channel variants. 3) functionally characterize variants in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). These technologies enable us to construct predictive models of ion channel phenotypes and validate the resulting predictions. Job Duties: 75% Pursue an independent research project to investigate the significance of cardiac ion channel variants to the individuals who carry them. 25% Assist with training staff and laboratory maintenance (Nanion patchliner and publicly available datasets and websites). Minimum Qualifications: PhD in Biology/Chemistry/Biochemistry, Genomics/Genetics, Bioinformatics or related field. Previous experience working with ion channels, especially planar patch clamp methodologies, human induced pluripotent stem cell differentiation to cardiomyocytes or high-throughput cell-based assays is desired. Strong verbal and written communication skills are essential. Salary will be set commensurate with experience and accomplishments as well as NIH guidelines. Working at Vanderbilt: Vanderbilt is a renowned private institution founded in 1873 located a little more than a mile from downtown Nashville, TN. |
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To apply, candidates must submit a letter of application, along with a CV including list of publications and three letters of recommendation, to Brett Kroncke. |
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| Brett Kroncke, PhD : brett.kroncke@gmail.com : (608) 658-8372 |
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| 2018-09-14 20:07:15 |