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Past Projects

The following is a list of some of the research projects students have completed in past summers:

Biochemistry
  • PKA-induced phosphorylation of p65 is necessary for NF-kB activation in Schwann cells
  • Crystallization of the cyanobacteria circadian clock protein
  • Inhibition and Analysis of COX-1 and COX-2A in Zebrafish
Biological Sciences
  • MonoUbiqitin mediated Drs2p sorting into the MVB pathway
  • Role of G-proteins in Dictyostelium discoideum slug phototaxis
  • The development of primers to detect sewage pollution in recreational water
  • Investigating the roles of Apelin in zebrafish development by using the Gal4/UAS system
Biomedical Engineering
  • Surface modification of HTR to increase porosity and cell adhesion
Cancer Biology
  • RGS2 Protein Expression in Myeloid Cells in Response to Cell Stress
Cell and Developmental Biology
  • Determining the cytoarchitecture of the left lateral plate mesoderm in Xenopus laevis
  • Genetic analysis of UNC-4 suppressor mutants
  • Diet modulates egg production in dFOXO-independent manner
  • Notch signaling pathway's role in hepatogenesis
  • Phosphorylation interactions of clp1
Center for Human Genetic Research
  • Determining the effects of citrulline on the regulation of urea cycle enzymes and nitric oxide cycle synthases
  • Potential role for PYY in appetite suppression associated with UCD patients
  • Evidence for oxidant injury from hyperoxia during cardiac surgery
Chemical Engineering
  • Polyurethane-mineralized bone powder composites
Chemistry
  • Assessing the capabilities of fragment-independent encoding of drug-like molecules using radial distribution functions and artificial neural networks
  • Novel molecular transporter for the delivery of bioactive cargo
  • Computational de novo folding of the leucine transporter membrane protein
Earth and Environmental Sciences
  • Hydrothermal zircon growth at high pressures and temperatures
  • Testing for the provenance differences in aquifer sands from arsenic infected regions of Nepal using rare earth elements and zircon geochronology
  • The layering of calcium carbonate as it relates to changes in climate
Electrical Engineering and Computer Science
  • Acoustical properties of speech as indicators of depression and suicidal risk
  • Validating a perceptual concept of locus
Hearing and Speech Sciences
  • Preschoolers' production of complement clauses in an elicited language task
Mechanical Engineering
  • Electro-osmotic pumping flow rate optimization via annealing
Medicine
  • The effect of resveratrol on renal sodium excretion in mice fed with high sodium diet
  • Effect of Rev M10 on SIV RRE-mediated expression of HIV Gag-Pol
  • Effect of Rev M10 on CTE-mediated expression of HIV Gag-Pol
  • The role of MTG8 in intestinal and colonic biology
  • The disruption of embryonic signaling pathways as a result of exposure to small molecule compounds
  • Developing an fMRI capable neck suction device for carotid sinus stimulation
  • Chemotherapy agent enhances citrullination in murine fibrotic lung tissue
Microbiology and Immunology
  • HIV uncoating perturbed by TRIM5α
  • Antimicrobial peptides that inhibit HIV and protect beneficial lactobacilli
Molecular Physiology and Biophysics
  • Analysis of CaMKII signaling complexes in mouse and rat striatum and hippocampus
  • MIP-1α’s role in the inflammatory response to fatty acids
  • Investigation of the endocytic pathway traversed by cholera toxin using fluorescence microscopy and image analysis
Pathology
  • Reactive oxygen species contribute to the tumorigenicity of polyploidy cells
  • Decrease in CCS from dithiocarbamates results from increase in bioavailability of copper in brain
Pediatrics
  • Manganese exposure induces neuronal injury
  • Gfi-1b interacts with the intracellular domain of Notch
Pharmacology
  • Strain-specific postnatal lethality in mutant mice solely expressing the fully-edited isoform of the serotonin 2C receptor
  • D1 and D2 dopamine receptor expression in corticostriatal neurons of the rat
  • MET protein expression in the cortex of uPAR -/- mice
  • Role of dopamine receptors in neuronal development
Physics and Astronomy
  • Calibration of an optical tweezer setup
  • The process of isotropic to anisotropic transformation from the nanocrystal to the nanospindle
  • Germ band retraction and dorsal closure of fruit fly embryo development image analyzing and processing
  • Optical properties in arrays of gold trimers

View the full abstracts from previous years of the Research Experience for High School Students: