{"id":5933,"date":"2025-03-07T07:35:13","date_gmt":"2025-03-07T13:35:13","guid":{"rendered":"https:\/\/www.vanderbilt.edu\/csb\/?p=5933"},"modified":"2025-03-07T07:35:13","modified_gmt":"2025-03-07T13:35:13","slug":"csb-research-spotlight-x-ray-crystallography-paving-the-way-for-hypoallergen-treatments-against-peanut-allergies","status":"publish","type":"post","link":"https:\/\/www.vanderbilt.edu\/csb\/2025\/03\/07\/csb-research-spotlight-x-ray-crystallography-paving-the-way-for-hypoallergen-treatments-against-peanut-allergies\/","title":{"rendered":"CSB Research Spotlight: X-ray Crystallography – Paving the way for \u2018hypoallergen\u2019 treatments against peanut allergies"},"content":{"rendered":"

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The chart on the left shows the panel of peanut-reacting antibodies that the Smith lab isolated from food-allergic patients, indicating that most of the antibodies bound two peanut proteins, Ara h 2 and Ara h 6. The chart in the middle shows a subset of those antibodies separated into six color-coded categories of antibodies that all bind to specific sites within Ara h 2 and Ara h 6. The structures on the right show Ara h 6 with the binding sites identified in the second chart color coded onto its structure. (Images adapted from Smith et al., Journal of Allergy and Clinical Immunology, Jan. 11, 2025, and Smith et al., Journal of Allergy and Clinical Immunology, Jan. 12, 2025, and shared in accordance with a CC BY 4.0 license.)<\/figcaption><\/figure>\n

Ben Spiller<\/strong><\/a>, associate professor of pharmacology, and collaborators recently published two papers that dig into how peanut allergies are provoked and providing support for the use of a potential treatment option: hypoallergens. Both papers were published in February in the Journal of Allergy and Clinical Immunology<\/em>.<\/p>\n

Read more<\/a> about how the IgE antibodies\u2019 structural, immunological and functional properties interact with peanut allergens.<\/p>\n

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Ben Spiller, associate professor of pharmacology, and collaborators recently published two papers that dig into how peanut allergies are provoked and providing support for the use of a potential treatment option: hypoallergens. Both papers were published in February in the Journal of Allergy and Clinical Immunology. Read more about how the IgE antibodies\u2019 structural, immunological…<\/p>\n","protected":false},"author":1185,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"spay_email":"","jetpack_publicize_message":"","jetpack_is_tweetstorm":false,"jetpack_publicize_feature_enabled":true},"categories":[1],"tags":[],"acf":[],"jetpack_featured_media_url":"","jetpack_publicize_connections":[],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/posts\/5933"}],"collection":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/users\/1185"}],"replies":[{"embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/comments?post=5933"}],"version-history":[{"count":6,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/posts\/5933\/revisions"}],"predecessor-version":[{"id":5940,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/posts\/5933\/revisions\/5940"}],"wp:attachment":[{"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/media?parent=5933"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/categories?post=5933"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.vanderbilt.edu\/csb\/wp-json\/wp\/v2\/tags?post=5933"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}