News
Research Spotlight: Fesik Lab
Jun. 14, 2024—Fesik Lab: BI-0474 Researchers from the lab of Stephen Fesik, Orrin H. Ingram II Chair in Cancer Research, have added BI-0474 as the second molecule co-discovered by Vanderbilt to the open science portal opnMe.com, an initiative being driven by biopharmaceutical company Boehringer Ingelheim. Read more on the Basic Sciences website.
Putting the fun back in antifungals: new insights into Acanthamoeba drug targets
Jun. 7, 2024—Acanthamoeba is a genus of free-living pathogenic protozoa found ubiquitously in the environment. In humans, acanthamoeba can cause diseases such as blinding keratitis, an infection of the eye, or granulomatous amebic encephalitis (GAE), a generally fatal infection of the brain and spinal cord. Antifungals which target the biosynthesis of fungal sterols, such as ergosterol, are...
Iverson named Associate Dean for Faculty
Jun. 4, 2024—Tina Iverson, Louise B. McGavock Professor and professor of pharmacology and biochemistry, has been named School of Medicine Basic Sciences Associate Dean for Faculty to be effective July 1. In addition to her professorships, Iverson is an active member of the Center for Structural Biology and the Vanderbilt Institute for Infection, Immunology, and Inflammation. Her...
STOP the GAP: new cryo-ET package aims to fill in the missing wedge
May. 31, 2024—Traditional cryogenic electron microscopy relies on imaging proteins frozen in a monolayer of vitrified ice. Subsequent single particle analysis compiles images of the protein in different orientations and outputs a 3D reconstruction. Unfortunately, if proteins overlap or favor a specific orientation, a high-resolution structure cannot be determined. Cryogenic electron tomography (cryo-ET) addresses some of these...
Remote Access Crystallography at SSRL workshop
May. 21, 2024—Jamaine Davis, Meharry Medical College, is hosting an in-person workshop on Remote Access Crystallography at Stanford Synchrotron Radiation Lightsource (SSRL) on the campus of Meharry Medical College on Friday, May 24, 2024, 9am–3pm. The Stanford Synchrotron Radiation Lightsource (SSRL) provides state-of-the-art facilities for structural biology research to the academic research community. All SSRL crystallography beam...
Teasing out a role for tepsin in AP-4 mediated trafficking
May. 21, 2024—AP-4 is one complex in a family of coat proteins that mediate vesicle formation at various membranes. Previous work has determined that AP-4 is recruited specifically to the trans-Golgi network, but the exact mechanisms governing AP-4 vesicle budding or distribution are still poorly understood. Further, loss of the AP-4 complex in humans results in a...
Vanderbilt Phenocam goes live
May. 21, 2024—The Phenocam at Vanderbilt monitors changes in tree canopy greenness and updates at thirty-minute intervals. The footage will provide researchers in the Department of Earth and Environmental Sciences with permanent continuous data on the vegetation dynamics on campus under climate change. The Vanderbilt site is part of the PhenoCam Network, a cooperative network of more than...
Vanderbilt launches sustainable lab program
May. 21, 2024—Did you know that laboratory spaces traditionally consume about five times more energy per square foot than standard office spaces? In an effort to help reduce the environmental impact of lab activities, Vanderbilt has launched the Vanderbilt Sustainable Labs program. VSL is an initiative from Environmental Health, Safety and Sustainability in the Division of Administration...
Iverson Lab provides new insights on chemotaxis
May. 3, 2024—The lab of Tina Iverson, Louise B. McGavock Professor and professor of pharmacology, in collaboration with researchers at the University of California, San Francisco; Stanford University; and The Weizmann Institute of Science in Israel have published new work in Nature Microbiology, providing new insights on chemotaxis. Chemotaxis is a key characteristic shared by all infectious...
Chazin to lead biomedical research education and training
Apr. 9, 2024—Congratulations to Walter Chazin, founder and former director of the Center of Structural Biology, on being named senior associate dean of BRET! Walter takes over from Kathleen Gould, who steps down after 14 years of leading the BRET Office to return her focus to her research program. Read the full announcement on the Basic Sciences...
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