Mass Spectrometry Center for Innovative Technology at Vanderbilt University

We enable innovative research using LC-MS/MS LC-IM-MS/MS LC-QQQ/MS High-Content Confocal Microscopy

The Center for Innovative Technology at Vanderbilt is a collaborative shared resource facility for mass spectrometry research and has an array of cutting-edge instrumentation for numerous types of mass spec analyses available. We specialize in global, untargeted metabolomics and as s a result, our Center offers support in numerous phases of the analytical pipeline to our clients. We provide several routine and/or advanced services that can be tailored to the goals of individual research projects and a wide range of biospecimens. If needed, new workflows can be established for method development, targeted biomolecule measurement acquisition, and/or metabolite validation.

The goal of metabolomics is to measure the complex collection of small molecule metabolites present within a fluid, cell, or tissue. Unlike an organism’s genome, metabolomic measurements are dynamic and thus the analysis results are context dependent. Consequently, data either identifies reproducible steady state, and/or temporal changes associated with disease state, toxicant exposure, or drug administration. Metabolite identifications are assigned based on high mass accuracy measurements, isotope distributions, tandem MS fragmentation patterns, and comparisons with spectral libraries and standards. Data analysis results can reveal unique biochemical fingerprints of cellular processes specific to each sample. For this reason, results can be exploited as a discovery-based approach for generating novel hypotheses or used for a better understanding of physiological processes mediated by genetic or environmental perturbations.

MISSION

To provide innovative and tailored solutions to analytical challenges using cutting-edge instrumentation and methodologies for academia and industry.

VISION

To transform human health by being a trusted leader in emerging omics approaches and setting the standard for quality research.

The CIT is also committed to the training, education, and research for next generation scholars, and is a participating member of several outreach and training programs at Vanderbilt University, including the Vanderbilt Center for Science Outreach (VCSO, high school students), the Systems Biology and Bioengineering Undergraduate Research Experience (SyBBURE, undergraduate students), the Chemical-Biology Interface Training Program (CBI, graduate students), the Quantitative and Chemical Biology Graduate Program (QCB, graduate students), and the Interdisciplinary Graduate Program in the Biomedical Sciences (IGP, graduate students).

  • Cutting Edge Technology

    We are able to accommodate intensive metabolomic research, data analytics, and data mining with our extensive lineup of state-of-the-art mass spectrometry instrumentation and software.

  • Dedicated Service

    We have an experienced team with over 30 years of combined experience in mass spectrometry, data analysis, and informatic pipelines. In addition, our shared resource center offers a highly flexible and tailored approach for a wide range of applications, while our team is ready to guide the best fit-for-purpose for your project.