predoctoral training
Average Years to Phd: 4.4
Average # Publications/pHd: 4.6
 

William “Will” Walker 2003-2008


BS: Michigan State University (2001)

Thesis Project: “On The Nature Of The Sensory Arrestins Of The Dipteran Insects Anopheles gambiae And Drosophila melanogaster”

Support: Department of Biological Sciences

Current Position: Postdoctoral Fellow, Swedish Agricultural University, Alnarp SWEDEN


Thesis Publication:

A Functional Role for Anopheles gambiae Arrestin 1 in Olfactory Signal Transduction.  William B. Walker, Elaine M. Smith and L.J. Zwiebel. J. Insect Physiology (2008) April; 54(4): 680-690.

Tan Lu             2003-2008


BS: Nanjing University, PRC (2001)

Thesis Project: Mapping of Odor and Temperature Receptors in the Malaria Vector Mosquito Anopheles gambiae

Current Position: Associate, Vinson and Ekins LLP, Houston TX


Publications:

Novel Olfactory Responses in a Gustatory Organ of the Malaria Vector Mosquito, Anopheles gambiae Hyung-Wook Kwon, Tan Lu, Michael Rützler, and L. J. Zwiebel, Proceedings of the National Academy of Sciences (2006) 103: 13526-13531.


The G Encoding Gene Family Of The Malaria Vector Mosquito Anopheles gambiae: Expression Analysis And Immunolocalization Of Gq, Gs And Go In Female Antennae M. Rützler, Tan Lu and L.J. Zwiebel, The Journal of Comparative Neurology (2006), 499:533-545.


Odor Coding in the Maxillary Palp of the Malaria Vector Mosquito Anopheles gambiae.  T. Lu*, G. Wang*, YT. Qiu,* J.Y. Young*, M. Rutzler, H.W. Kwon, R. J. Pitts, J. J.A. van Loon, J. R. Carlson, W. Takken, and L. J. Zwiebel.  Current Biology (2007) Sept. 18; 17(18): 1533-1544. Epub 2007 Aug 30.


Anopheles gambiae TRPA1 is a heat-activated channel expressed in thermosensitive sensilla of female antennae. Guirong Wang*, Yu Tong Qiu*, Tan Lu, HW Kwon, R. Jason Pitts, Joop J.A. van Loon, Willem Takken and L. J. Zwiebel. European Journal of Neuroscience (2009) 30: 967-974.

Yuanfeng Xia       2003-2008


BS: Beijing University, PRC (2003)

Thesis Project: Molecular and cellular studies of mosquito odorant receptors and olfactory-driven larval behavior

Current Position: Director of Assay Development, HD Biosciences, Shanghai, PRC


Publications:

Identification and Characterization of an Odorant Receptor from the West Nile Virus Mosquito, Culex quinquefasciatus Yuanfeng Xia and Laurence J. Zwiebel Insect Molecular Biology and Biochemistry (2006) 36: 169-176.

The Molecular and Cellular Basis of Olfactory Behavior in Anopheles gambiae Larvae. Yuanfeng Xia*, Guirong Wang*, Daniela Buscariollo, R. Jason Pitts, Heidi Wegner and L. J. Zwiebel. Proceedings of the National Academy of Sciences, (2008) Apr 29;105(17):6433-8. Epub 2008 Apr 21.

Patrick Jones      2007-2011


BS: College of the Holy Cross (2006)

Thesis Project: Structure/Function Relationships in the Olfactory System of Anopheles gambiae

Current Position: Postdoctoral Fellow, Harvard School of Public Health/Genzyme, Boston MA


Publications:

Distinct Olfactory Signaling Mechanisms in the Malaria Vector Mosquito Anopheles gambiae. Chao Liu*, R. Jason Pitts*, Jonathan Bohbot, Patrick L. Jones, Guirong Wang and Laurence J. Zwiebel.  PLoS Biology (2010) 8(8): e1000467 doi:10.1371/ journal.pbio.1000467.


Functional Agonism of Insect Odorant Receptor Ion Channels.  Patrick L. Jones*, Gregory M. Pask*, David Rinker and Laurence J. Zwiebel. Proceedings of the National Academy of Sciences USA, (2011) May 24, 108 (21): 8821-8825 published ahead of print May 9, 2011, doi:10.1073/pnas.1102425108.


Transcriptome Profiling of Chemosensory Appendages in the Malaria Vector Anopheles gambiae Reveals Tissue- and Sex-Specific Signatures of Gene Expression. R. Jason Pitts*, David C. Rinker*, Patrick L. Jones*, Antonis Rokas and Laurence J. Zwiebel. BMC Genomics  (2011) 12:271.


Conservation of Indole Responsive Odorant Receptors in Mosquitoes Reveals an Ancient Olfactory Trait.  Jonathan D. Bohbot*, Patrick L. Jones*, Guirong Wang*, R. Jason Pitts, Gregory M. Pask, and Laurence J. Zwiebel.  Chemical Senses (2011) Jan; 36(2): 149-60. Epub 2010 Oct 18.


Functional Antagonism of Insect Odorant Receptor Ion Channels.  Patrick L. Jones, Gregory M. Pask, Ian M. Romaine, Robert W. Taylor, Paul R. Reid, Alex G. Waterson, Gary A. Sulikowski and Laurence J. Zwiebel. PLoS ONE (2012) 7(1): e30304. doi:10.1371/ journal.pone.0030304.


Novel high-throughput screens of Anopheles gambiae odourant receptors reveal candidate behaviour-modifying chemicals for mosquitoes. David C. Rinker*, Patrick L. Jones*, R. Jason Pitts, Michael Rützler, J. Gray Camp, Lujuan Sun, Pingxi Xu, Daniel Dorset, David Weaver and Laurence J. Zwiebel, Physiological Entomology (2012) 37, 33-41.

  1. R.Jason Pitts        2007-2011


BS: Ball State University (1993)

MA: Indiana University (1998)

Thesis Project: Novel Chemoreceptors and Gene Expression Profiling in Antennae and Maxillary Palps of Anopheles gambiae

Current Position: Assistant Professor, Department of Biological Sciences, Vanderbilt University


Publications:

Distinct Olfactory Signaling Mechanisms in the Malaria Vector Mosquito Anopheles gambiae. Chao Liu*, R. Jason Pitts*, Jonathan Bohbot, Patrick L. Jones, Guirong Wang and Laurence J. Zwiebel.  PLoS Biology (2010) 8(8): e1000467 doi:10.1371/ journal.pbio.1000467.


Transcriptome Profiling of Chemosensory Appendages in the Malaria Vector Anopheles gambiae Reveals Tissue- and Sex-Specific Signatures of Gene Expression. R. Jason Pitts*, David C. Rinker*, Patrick L. Jones*, Antonis Rokas and Laurence J. Zwiebel. BMC Genomics  (2011) 12:271.


Conservation of Indole Responsive Odorant Receptors in Mosquitoes Reveals an Ancient Olfactory Trait.  Jonathan D. Bohbot*, Patrick L. Jones*, Guirong Wang*, R. Jason Pitts, Gregory M. Pask, and Laurence J. Zwiebel.  Chemical Senses (2011) Jan; 36(2): 149-60. Epub 2010 Oct 18.


Novel high-throughput screens of Anopheles gambiae odourant receptors reveal candidate behaviour-modifying chemicals for mosquitoes. David C. Rinker*, Patrick l. Jones*, R. Jason Pitts, Michael Rützler, J. Gray Camp, Lujuan Sun, Pingxi Xu, Daniel Dorset, David Weaver and Laurence J. Zwiebel, Physiological Entomology (2012) 37, 33-41.

Chao Liu            2009-2013


BS: Nanjing University, PRC (2008)

Thesis Project: Behavioral Analysis of Olfaction in Anopheles gambiae Larvae

Current Position: Postdoctoral Fellow, University of California, Santa Barbara.


Publications:

Distinct Olfactory Signaling Mechanisms in the Malaria Vector Mosquito Anopheles gambiae. Chao Liu*, R. Jason Pitts*, Jonathan Bohbot, Patrick L. Jones, Guirong Wang and Laurence J. Zwiebel.  PLoS Biology (2010) 8(8): e1000467 doi:10.1371/ journal.pbio.1000467.


Structure-Activity Relationship of a Broad-Spectrum Insect Odorant Receptor AgonistRobert W. Taylor, Ian M. Romaine, Chao Liu, Poornima Murthi, Patrick L. Jones, Alex G. Waterson, Gary A. Sulikowski and Laurence J. Zwiebel, ACS Chemical Biology (2012) August 27, (Letters) doi:10.1021/cb300331z.


Molecular Characterization of Larval Peripheral Thermosensory Responses of the Malaria Vector Mosquito Anopheles gambiae. Chao Liu and Laurence J. Zwiebel, PLoS ONE, published 07 Aug 2013 | PLOS ONE 10.1371/journal.pone.00725.


Odorant Receptor-Mediated Sperm Activation in Disease Vector Mosquitoes R. Jason Pitts*, Chao Liu*, Xiaofan Zhou* and Laurence J Zwiebel, Proceedings of the National Academy of Sciences USA (2014) ) 111 (7) 2566-2571, doi: 10.1073/pnas.1322923111. Epub 2014 Jan 29



Greg Pask            2009-2013


BS: Muhlenberg College (2008)

Thesis Project: Structure/Function of Anopheles gambiae Odorant Receptors

Support: NIDCD 1F31DC011989

Current Position: Postdoctoral Fellow, University of California, Riverside.


Publications:

Conservation of Indole Responsive Odorant Receptors in Mosquitoes Reveals an Ancient Olfactory Trait.  Jonathan D. Bohbot*, Patrick L. Jones*, Guirong Wang*, R. Jason Pitts, Gregory M. Pask, and Laurence J. Zwiebel.  Chemical Senses (2011) Jan; 36(2): 149-60. Epub 2010 Oct 18.


Functional Agonism of Insect Odorant Receptor Ion Channels.  Patrick L. Jones*, Gregory M. Pask*, David Rinker and Laurence J. Zwiebel. Proceedings of the National Academy of Sciences USA, (2011) May 24, 108 (21): 8821-8825 published ahead of print May 9, 2011, doi:10.1073/pnas.1102425108.


Heteromeric Anopheline Odorant Receptors Exhibit Distinct Channel Properties. Gregory M. Pask, Patrick L. Jones, Michael Rützler, David Rinker and Laurence J. Zwiebel. PLoS ONE (2011) 6(12): e28774. doi:10.1371/journal.pone.0028774.


Functional Antagonism of Insect Odorant Receptor Ion Channels.  Patrick L. Jones, Gregory M. Pask, Ian M. Romaine, Robert W. Taylor, Paul R. Reid, Alex G. Waterson, Gary A. Sulikowski and Laurence J. Zwiebel. PLoS ONE (2012) 7(1): e30304. doi:10.1371/ journal.pone.0030304.


The Molecular Receptive Range of an Enantio-selective Lactone Receptor in Anopheles gambiae. Gregory M. Pask, Ian M. Romaine and Laurence J. Zwiebel, Chemical Senses (2013) doi:10.1093/chemse/bjs074. Epub 2012 Sep 2.


Blockade of Insect Odorant Receptors with Amiloride Derivatives. Gregory M. Pask, Yuriy V. Bobkov, Elizabeth A. Corey, Barry W. Ache and Laurence J. Zwiebel, Chemical Senses (2013) first published online January 2, doi:10.1093/chemse/bjs100.


A Conserved Aspartic Acid Regulates Gating of the Insect Odorant Co-Receptor Orco. Brijesh N. Kumar, Robert W. Taylor, Gregory M. Pask, Laurence  J. Zwiebel, Richard D. Newcomb and David L. Christie, PLoS ONE, published 23 Jul 2013 | PLOS ONE 10.1371/journal.pone.0070218.


David Rinker         2010-present


BA: College of William and Mary (1994)

Thesis Project: Comparative Transcriptomics of Disease Vector Mosquitoes

Support: Center for Human Genetics Research /NIDCD 1F31DC012991


Publications:

Functional Agonism of Insect Odorant Receptor Ion Channels.  Patrick L. Jones*, Gregory M. Pask*, David Rinker and Laurence J. Zwiebel. Proceedings of the National Academy of Sciences USA, (2011) May 24, 108 (21): 8821-8825 published ahead of print May 9, 2011, doi:10.1073/pnas.1102425108.


Transcriptome Profiling of Chemosensory Appendages in the Malaria Vector Anopheles gambiae Reveals Tissue- and Sex-Specific Signatures of Gene Expression. R. Jason Pitts*, David C. Rinker*, Patrick L. Jones*, Antonis Rokas and Laurence J. Zwiebel. BMC Genomics  (2011) 12:271.


Heteromeric Anopheline Odorant Receptors Exhibit Distinct Channel Properties. Gregory M. Pask, Patrick L. Jones, Michael Rützler, David Rinker and Laurence J. Zwiebel. PLoS ONE (2011) 6(12): e28774. doi:10.1371/journal.pone.0028774.


Novel high-throughput screens of Anopheles gambiae odourant receptors reveal candidate behaviour-modifying chemicals for mosquitoes. David C. Rinker*, Patrick l. Jones*, R. Jason Pitts, Michael Rützler, J. Gray Camp, Lujuan Sun, Pingxi Xu, Daniel Dorset, David Weaver and Laurence J. Zwiebel, Physiological Entomology (2012) 37, 33-41.


Blood Meal-Induced Changes to Antennal Transcriptome Profiles Reveal Shifts In Odor Sensitivities in Anopheles gambiae.  David C Rinker, Ronald Jason Pitts, Xiaofan Zhou, Eunho Suh, Antonis Rokas and Laurence J. Zwiebel, Proceedings of the National Academy of Sciences USA (2013) published ahead of print April 29, 2013, doi:10.1073/pnas.1302562110


Antennal transcriptome profiles of anopheline mosquitoes reveal human host olfactory specialization in Anopheles gambiae. David Rinker, Xiaofan Zhou, R. Jason Pitts, Antonis Rokas and Laurence J Zwiebel, BMC Genomics, 2013, 14:749. doi:10.1186/1471-2164-14-749. Epub 2013 Nov 1.





A. Nicole “Nicky” Fox  1999-2002

BS. Southern Methodist University (1998)
Thesis Project: “Odorant Receptors in the Malaria Vector Mosquito Anopheles gambiae”
Support: Program in Developmental Biology /NIDCD 1F31DC05264
Current Position: Senior Research Scientist, Department of Neurobiology, University of Massachusetts Worcester, MA.

Thesis Publications:
Candidate Odorant Receptors from the Malaria Vector Mosquito Anopheles gambiae and Evidence of Downregulation in Response to Blood Feeding. Fox, A.N.*, Pitts, R.J.*, Robertson, H.M., Carlson, J. and Zwiebel, L.J. Proceedings of the National Academy of Science, USA (2001) 98: 14693-14697.

A Cluster of Candidate Odorant Receptors from the Malaria Vector Mosquito, Anopheles gambiae. Fox, A.N.*, Pitts, R.J.*, and Zwiebel, L.J. Chemical Senses (2002) Jun; 27 (5): 453-459.

G-protein Coupled Receptors in the Malaria Anopheles gambiae. Hill, C.H.*, Fox, A.N.*, Pitts, R.J.*, Hunt, L.H., Collins, F.C., Robertson, H.M. and L.J. Zwiebel, Science (2002) 298:176-178. 

A Mosquito Odor Receptor for a Component of Human Sweat. Hallem, E., Fox, A. N., Zwiebel, L.J. and J. R. Carlson, Nature, (2004) 427:212-213.

A Highly Conserved Candidate Chemosensory Receptor Expressed in Both Olfactory and Gustatory Tissues in the Malaria Vector Mosquito, Anopheles gambiae. R. J. Pitts, A. N. Fox and L.J. Zwiebel, Proceedings of the National Academy of Sciences, (2004) 101: 5058-5063.

Catherine Elaine Merrill 1999-2004


BS. Wake Forest University (1998)

Thesis Project: “Molecular, physiological, and behavioral characterization of sensory arrestins in insect olfaction”

Support: Program in Neuroscience/NIDCD 1F31DC05365

Current Position: Postdoctoral Fellow, Neuroscience, Northwestern University School of Medicine


Thesis Publications:

Visual Arrestins in Olfactory Pathways of Drosophila and the Malaria Vector Mosquito Anopheles gambiae. Merrill, C.E., Riesgo-Escovar,J., Pitts, R.J., Kafatos, F.C., Carlson, J.R. and Zwiebel, L.J. (2002) Proceedings of the National Academy of Science, USA 99: 1633-1638.


Molecular Characterization of Arrestin Family Members in the Malaria Vector Mosquito Anopheles gambiae. C. Elaine Merrill, R. Jason Pitts and L. J. Zwiebel, Insect Molecular Biology (2003) 12 (6) 641-650.


Odorant-Specific Requirements for Arrestin Function in Drosophila Olfaction.  Merrill, E.C., Sherertz, T. Walker, W. B. and L.J. Zwiebel, J. Neurobiology (2005) 63(1) 15-28.


A Functional Role for Anopheles gambiae Arrestin 1 in Olfactory Signal Transduction.  William B. Walker, Elaine M. Smith and L.J. Zwiebel. J. Insect Physiology (2008) April; 54(4): 680-690.