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Manning, Charles
Assisant Profesor of Radiology & Radiological Sciences

Research Information

Our multi-disciplinary research program involves the development, validation, and translation of non-invasive molecular imaging metrics to assess disease progression and response to therapy. Projects within our program emphasize molecular imaging of cancer, and notably imaging-based assessment of response to anti-cancer pharmaceuticals in colorectal and breast cancer. We are actively engaged in advancing novel methods to image molecular events in both humans and animal models that include receptor expression, proliferation, angiogenesis, and apoptosis. Among these methods include validation of imaging probes for novel applications, as well as high-throughput small-molecule discovery to develop novel imaging compounds.


Selected Publications

A Novel In Vitro Assay to Assess Phosphorylation of 3 '-[F-18]fluoro-3 '-Deoxythymidine. Guo, N; Xie, JP; Manning, HC; Deane, NG; Ansari, MS; Coffey, RJ; Gore, J; Price, RR; Baldwin, RM; McIntyre, JO, MOLECULAR IMAGING AND BIOLOGY, 13, 257-264 , (2011)

Microwave-assisted organic synthesis of a high-affinity pyrazolo-pyrimidinyl TSPO ligand. Tang, DW; Buck, JR; Hight, MR, Manning, HC, TETRAHEDRON LETTERS, 51, 4595-4598 , (2010)

Molecular imaging of the translocator protein (TSPO) in a pre-clinical model of breast cancer. Wyakk, SK; Manning, HC; Bai, MF; Bailey, SN; Gallant, P; Ma, GB; McIntosh, L; Bornhop, DJ, MOLECULAR IMAGING AND BIOLOGY, 12, 349-358 , (2010)

Volume of preclinical xenograft tumors is more accurately assessed by ultrasound imaging than manual caliper measurements. Ayers, GD; McKinley, ET; Zhao, P, Fritz, JM; Metry, RE; Deal, BC, Adlers, KM; Coffey, RJ; Manning, HC, JOURNAL OF ULTRASOUND IN MEDICINE, 29, 891-901 , (2010)

A molecular imaging paradigm to rapidly profile response to angiogenesis-directed therapy in small animals. Virostko, J; Xie, JP; Hallahan, DE; Arteaga, CL; Gore, JC; Manning, HC, MOLECULAR IMAGING AND BIOLOGY, 11, 204-212 , (2009)

Binding of NIR-conPK and NIR-6T to astrocytomas and microglial cells: evidence for protein related to TSPO. Sexton, M; Woodruff, G; Cudaback, E; Kreitzer, FR; Xu, C; Lin, YH; Moller, T; Bai, MF; Manning, HC; Bornhop, D; Stella, N, PLOS ONE, 4, e8271 , (2009)

Imaging biomarkers predict response to Anti-HER2 (ErbB2) therapy in preclinical models of breat cancer. Shah, C; Miller, TW; Wyatt, SK; McKinley, ET; Olivares, MG; Sanchez, V; Nolting, DD; Buck, JR; Zhao, P; Ansari, MS; Baldwin, RM; Gore, JC; Schiff, R; Arteaga, CL; Mannings, HC, CLINICAL CANCER RESEARCH, 15, 4712-4721 , (2009)

Inhibition of mammalian target of rapamycin is required for optimal antitumor effect of HER2 inhibitors against HER2-overexpressing cancer cells. Miller, TW; Forbes, JT; Shah, C; Wyatt, SK; Manning, HC; Olivares, MG; Sanchez, V; Dugger, TC; Granja, ND; Narasanna, A; Cook, RS; Kennedy, JP; Lindsley, CW; Arteaga, CL, CLINICAL CANCER RESEARCH, 15, 7266-7276 , (2009)

Multispectral molecular imaging of capillary endothelium to facilitate preoperative endovascular brain mapping. Manning, HC; Shay, SD; Mericle, RA, JOURNAL OF NEUROSURGERY, 110, 975-980 , (2009)

PHOSPHORYLATION AND UPTAKE OF 3-DEOXY-3-[18F]FLUOROTHYMIDINE IN COLON CANCER CELL LYSATES. Guo, N; Xie, J; Manning, HC; Deane, NG; Ansari, MS; Coffey, RJ; Gore, J; Price, RR; Baldwin, RM; McIntyre, JO, JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 52, S414-S414 , (2009)


Phone: 615-322-3793
Email: henry.c.manning@vanderbilt.edu
Website: Click to Visit

 
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