Duvall, Craig Research Information
Assistant Professor of Biomedical Engineering
The advanced therapeutics laboratory applies “smart”, environmentally-responsive polymers to develop novel approaches for overcoming pharmacological barriers. A variety of projects are currently under way for development of polymeric systems that respond to one or more stimuli such as pH, temperature, oxidative stress, and enzymatic activity in order trigger advanced polymer functionalities. Approaches currently under development are aimed at enhanced drug and nanoparticle targeting, intracellular biomacromolecular delivery, and systems for controlled release of growth factors and other extracellular-acting molecules. Medical application areas include cancer, wound healing and tissue regeneration, and improvement of long-term patency in vascular bypass grafts. For more specific project information please reference the ‘Research’ tab.
The Duvall lab is housed within an approximately 2000 ft2 Biomaterials Laboratory shared with Professor Hak-Joon Sung in the Stevenson Center. This collaborative research environment contains the multidisciplinary expertise and equipment necessary to carry out cutting edge research that covers the full spectrum of synthesis, characterization, and biological testing of advanced therapeutic biomaterials.
Intracellular delivery of a proapoptotic peptide via conjugation to a RAFT synthesized endosomolytic polymer. Duvall, CL; Convertine, AJ; Benoit, DSW; Hoffman, AS, Stayton, PS, MOLECULAR PHARMACEUTICS, 7, 468-476 , (2010)
Intracellular delivery of a protein antigen with an edosomal-releasing polymer enhances CD8 T-cell production and prophylactic vaccine efficacy. Foster, S; Duvall, CL; Crownover, EF; Hoffman, AS; Stayton, PS, BIOCONJUGATE CHEMISTRY, 21, 2205-2212 , (2010)
Sustained VEGF delivery via PLGA nanoparticles promotes vascular growth. Golub, JS; Kim YT; Duvall, CL; Bellamkonda, RV; Gupta, D; Lin, AS; Weiss, D; Taylor, WR; Guldberg, RE, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 298, H1959-H1965 , (2010)
Developement of a novel endosomolytic diblock copolymer for siRNA deliver. Convertine, AJ; Benoit, DSW; Duvall, CL; Hoffman, AS; Stayton, PS, JOURNAL OF CONTROLLED RELEASE, 133, 211-229 , (2009)
Prolyl hydroxylase inhibitors increase neoangiogensis and callus formation following femur fracture in mice. Shen, X; Wan, C; Ramaswamy G; Mavalli, M; Wang, Y; Duvall, CL; Deng, LF; Guldberg, RE; Eberhart, A; Clemens, TL; Gilbert SR, JOURNAL OF ORTHOPAEDIC RESEARCH, 27, 1298-1305 , (2009)
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