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Wikswo Jr., John P
Gordon A. Cain University Professor
A.B. Learned Professor of Living Physics
Professor of Physics and Astronomy, Biomedical Engineering, and Molecular Physiology and Biophyiscs

Research Information

Starting with cardiac and neural measurements on humans and animals in the 1970's, John is shrinking the spatial scale of his research by two orders of magnitude each decade. Presently, his research utilizes biological microelectromechanical systems (BioMEMS).and computer algorithms to instrument and control single cells and small cell populations, emphasizing cell signaling, motility, and metabolism. In his nanoscale decade, his group uses quantum dots to decorate T cells and microcantilevers and is developing instruments to characterize quantum-dot aggregation.

Selected Publications

Modeling the measurements of cellular fluxes in microbioreactor devices using thin enzyme electrodes. Velkovsky, M; Snider, R; Cliffel, DE; Wikswo, JP, JOURNAL OF MATHEMATICAL CHEMISTRY, 49, 251-275 , (2011)

A mathematical model of bone remodeling dynamics for normal bone cell populations and myeloma bone disease. Ayati, BP; Edwards, CM; Webb, GF; Wikswo, JP, BIOLOGY DIRECT, 5, 28 , (2010)

A metering rotary nanopump for microfluidic systems. Darby, SG; Moore, MR; Friedlander, TA; Schaffer, DK; Reiserer, RS; Wikswo, JP; Seale, KT, LAB ON A CHIP, 10, 3218-3226 , (2010)

Chips & Tips: A Method for Periodic Sterile Sample Collection During Continuous Cell Culture in Microfluidic Devices. Markov, DA; Lillie, EM; Samson, PC; Wikswo, JP; McCawley, LJ, LAB CHIP, , , (2010)

Cryogenic Etching of Silicon: An Alternative Method for Fabrication of Vertical Microcantilever Master Molds. Addae-Mensah, KA; Retterer, S; Opalenik, SR; Thomas, D; Lavrik, NV; Wikswo, JP, JOURNAL OF MICROELECTROMECHANICAL SYSTEMS, 19, 64-74 , (2010)

Four focus single particle position determination in cofocal microscope. Davis, LM; Canfield, BK; Germann, JA; King, JK; Robinson, WN; Dukes, AD; Rosenthal, SJ; Samson, PC; Wikswo, JP, PROCEEDINGS - SPIE, 7571, , (2010)

Increased cell migration and plasticity in Nrf2-deficient cancer cell lines. Rachakonda, G; Sekhar, KR; Jowhar, D; Samson, PC; Wikswo, JP; Beauchamp, RD; Datta, PK; Freeman, ML, ONCOGENE, 29, 3703-3714 , (2010)

Macro to nano: a simple method for transporting cultured cells from milliliter scale to nanoliter scale. Seale, KT; Faley, SL; Chamberlain, J; Wikswo, JP, EXPERIMENTAL BIOLOGY AND MEDICINE, 235, 777-783 , (2010)

Measurements of Transmembrane Potential and Magnetic Field at the Apex of the Heart. McBride, KK; Roth, BJ; Sidorov, VY; Wikswo, JP; Baudenbacher, FJ, BIOPHYSICAL JOURNAL, 99, 3113-3118 , (2010)

Open access microfluidic device for the study of cell migration during chemotaxis. Jowhar, D; Wright, G; Samson, PC; Wikswo, JP; Janetopoulos, C, INTEGRATIVE BIOLOGY, 2, 648-658 , (2010)

Tape underlayment rotary-node (TURN) valves for simple on-chip microfluidic flow control. Markov, DA; Manuel, S; Shor, LM; Opalenik, SR; Wikswo, JP; Samson, PC, BIOMEDICAL MICRODEVICES, 12, 135-144 , (2010)

The Effects of Cholera Toxin on Cellular Energy Metabolism. Snider, RM; McKenzie, JR; Kraft, L; Kozlov, E; Wikswo, JP; Cliffel, DE, TOXINS, 2, 632-634 , (2010)

Towards monitoring real-time cellular response using an integrated microfluidics-matrix assisted laser desorption ionisation/nanoelectrospray ionisation-ion mobility-mass spectrometry platform. Enders, JR; Marasco, CC; Kole, A; Nguyen, B; Sevugarajan, S; Seale, KT; Wikswo, JP; McLean, JA, IET SYSTEMS BIOLOGY, 4, 416-427 , (2010)

Window on a Microworld: Simple Microfluidic Systems for Styuding Microbial Transport in Porous Media. Markov, DA; Samson, PC; Schaffer, DK; Dhummakupt, A; Wikswo, JP; Shor, LM, JoVE, 39, 1-4 , (2010)

A model of the tumor microenvironment with scalable complexity. Ashby, WJ; Venkataraman, R; Wikswo, J; Zijlstra, A, CLINICAL & EXPERIMENTAL METASTASIS, 26, 905-905 , (2009)

In vivo analysis of tumor-host interactions within the oxygen and nutrient-deprived microenvironment of primary tumors. Hansen, AG; Zijlstra, A; Schaffer, DK; Olsen, E; Ashby, WJ; Wikswo, JP, CLINICAL & EXPERIMENTAL METASTASIS, 26, 894-894 , (2009)

Metabolic Discrimination of Select List Agents by Monitoring Cellular Responses in a Multianalyte Microphysiometer. Eklund, SE; Thompson, RG; Snider, RM; Carney, CK; Wright, DW; Wikswo, J; Cliffel, DE, SENSORS, 9, 2117-2133 , (2009)

Micro-Mirrors for Nanoscale Three-Dimensional Microscopy. Seale, K; Janetopoulos, C; Wikswo, J, ACS NANO, 3, 493-497 , (2009)

Microfluidic single cell arrays to interrogate signalling dynamics of individual, patient-derived hematopoietic stem cells. Faley, SL; Copland, M; Wlodkowic, D; Kolch, W; Seale, KT; Wikswo, JP; Cooper, JM, LAB ON A CHIP, 9, 2659-2664 , (2009)

Microfluidic Single-Cell Array Cytometry for the Analysis of Tumor Apoptosis. Wlodkowic, D; Faley, S; Zagnoni, M; Wikswo, JP; Cooper, JM, ANALYTICAL CHEMISTRY, 81, 5517-5523 , (2009)

Origin choice and petal loss in the flower garden of spiral wave tip trajectories. Gray, RA; Wikswo, JP; Otani, NF, CHAOS, 19, 033118 , (2009)

Partial independence of bioelectric and biomagnetic fields and its implications for encephalography and cardiography. Irimia, A; Swinney, KR; Wikswo, JP, PHYSICAL REVIEW E, 79, 051908 , (2009)

The Potential of Dual Camera Systems for Multimodal Imaging of Cardiac Electrophysiology and Metabolism. Holcomb, MR; Woods, MC; Uzelac, I; Wikswo, JP; Gilligan, JM; Sidorov, VY, EXPERIMENTAL BIOLOGY AND MEDICINE, 234, 1355-1373 , (2009)

3 '-phosphoinositides regulate the coordination of speed and accuracy during chemotaxis. Gruver, JS; Wikswo, JP; Chung, CY, BIOPHYSICAL JOURNAL, 95, 4057-4067 , (2008)

A microfabricated nanocalorimeter: Design, characterization, and chemical calibration. Xu, J; Reiserer, R; Tellinghuisen, J; Wikswo, JP; Baudenbacher, FJ, ANALYTICAL CHEMISTRY, 80, 2728-2733 , (2008)

A phased-array stimulator system for studying planar and curved cardiac activation wavefronts. Abbas, RA; Lin, SF; Mashbum, D; Xu, JK; Wikswo, JP, IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 55, 222-229 , (2008)

Characterization of transport in microfluidic gradient generators. Gorman, BR; Wikswo, JP, MICROFLUIDICS AND NANOFLUIDICS, 4, 273-285 , (2008)

Effects of unipolar stimulation on voltage and calcium distributions in the isolated rabbit heart. Sidorov, VY; Holcomb, MR; Woods, MC; Gray, RA; Wikswo, JP, BASIC RESEARCH IN CARDIOLOGY, 103, 537-551 , (2008)

Gastrointestinal arrhythmias are associated with statistically significant fluctuations in systemic information dimension. Irimia, A; Wikswo, JP, PHYSIOLOGICAL MEASUREMENT, 29, N33-N40 , (2008)

High-resolution high-speed panoramic cardiac imaging system. Evertson, DW; Holcomb, MR; Eames, MDC; Bray, MA; Sidorov, VY; Xu, J; Wingard, H; Dobrovolny, HM; Woods, MC; Gauthier, DJ; Wikswo, JP, IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 55, 1241-1243 , (2008)

Measurement techniques for cellular biomechanics in vitro. Addae-Mensah, KA; Wikswo, JP, EXPERIMENTAL BIOLOGY AND MEDICINE, 233, 792-809 , (2008)

Microfluidic platform for real-time signaling analysis of multiple single T cells in parallel. Faley, S; Seale, K; Hughey, J; Schaffer, DK; VanCornpernolle, S; McKinney, B; Baudenbacher, F; Unutmaz, D; Wikswo, JP, LAB ON A CHIP, 8, 1700-1712 , (2008)

Microfluidic switching system for analyzing chemotaxis responses of wortmannin-inhibited HL-60 cells. Liu, YX; Sai, JQ; Richmond, A; Wikswo, JP, BIOMEDICAL MICRODEVICES, 10, 499-507 , (2008)

Mirrored pyramidal wells for simultaneous multiple vantage point microscopy. Seale, KT; Reiserer, RS; Markov, DA; Ges, IA; Wright, C; Janetopoulos, C; Wikswo, JP, JOURNAL OF MICROSCOPY-OXFORD, 232, 1-6 , (2008)

Model-controlled hydrodynamic focusing to generate multiple overlapping gradients of surface-immobilized proteins in microfluidic devices. Georgescu, W; Jourquin, J; Estrada, L; Anderson, ARA; Quaranta, V; Wikswo, JP, LAB ON A CHIP, 8, 238-244 , (2008)

Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis. Sai, JQ; Raman, D; Liu, YX; Wikswo, J; Richmond, A, JOURNAL OF BIOLOGICAL CHEMISTRY, 283, 26538-26547 , (2008)

Polarity reversal lowers activation time during diastolic field stimulation of the rabbit ventricles: insights into mechanisms. Maleckar, MM; Woods, MC; Sidorov, VY; Holcomb, MR; Mashburn, DN; Wikswo, JP; Trayanova, NA, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 295, H1626-H1633 , (2008)

Protozoan migration in bent microfluidic channels. Wang, W; Shor, LA; LeBoeuf, EJ; Wikswo, JP; Taghon, GL; Kosson, DS, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 74, 1945-1949 , (2008)

Universal serial bus powered and controlled isolated constant-current physiological stimulator. Holcomb, MR; Bekele, RY; Lima, EA; Wikswo, JP, REVIEW OF SCIENTIFIC INSTRUMENTS, 79, 126103 , (2008)

A flexible, quantum dot-labeled cantilever post array for studying cellular microforces. Addae-Mensah, KA; Kassebaum, NJ; Bowers, MJ; Reiserer, RS; Rosenthal, SJ; Moore, PE; Wikswo, JP, SENSORS AND ACTUATORS A-PHYSICAL, 136, 385-397 , (2007)

A high-voltage cardiac stimulator for field shocks of a whole heart in a bath. Mashburn, DN; Hinkson, SJ; Woods, MC; Gilligan, JM; Holcomb, MR; Wikswo, JP, REVIEW OF SCIENTIFIC INSTRUMENTS, 78, 104302 , (2007)

Cathodal Stimulation in the Recovery Phase of a Propagating Planar Wave in the Rabbit Heart Reveals Four Stimulation Mechanisms. Sidorov, VY; Woods, MC; Baudenbacher, F; Wikswo, JP, J PHYSIOL, 583, 237-250 , (2007)

Dimensions of systems biology. Huang, S; Wikswo, J, REVIEWS OF PHYSIOLOGY BIOCHEMISTRY AND PHARMACOLOGY, VOL 157, 157, 81-104 , (2007)

Poly(vinyl alcohol) as a structure release layer for the microfabrication of polymer composite structures. Addae-Mensah, KA; Reiserer, RS; Wikswo, JP, JOURNAL OF MICROMECHANICS AND MICROENGINEERING, 17, N41-N46 , (2007)

SiO2-coated porous anodic alumina membranes for high flow rate electroosmotic pumping. Vajandar, SK; Xu, DY; Markov, DA; Wikswo, JP; Hofmeister, W; Li, DY, NANOTECHNOLOGY, 18, 275705 , (2007)

Interrogating the signaling synamics of T cell activation with quantum dots

. Warnement, MR; Faley, S; Wikswo, JP; Rosenthal, SJ, PROCEEDINGS - SPIE, 6096, 60T , (2006)

Voltage-Calcium State-Space Dynamics During Initiation of Reentry

. Gray, RA; Iyer, A; Bray MA; Wikswo, JP, HEART RHYTHM, 3, 247-248 , (2006)

Engineering challenges of BioNEMS: the integration of microfluidics, micro- and nanodevices, models and external control for systems biology. Wikswo, JP; Prokop, A; Baudenbacher, F; Cliffel, D; Csukas, B; Velkovsky, M, IEE PROCEEDINGS-NANOBIOTECHNOLOGY, 153, 81-101 , (2006)

Experimental evidence of improved transthoracic defibrillation with electroporation-enhancing pulses. Malkin, RA; Guan, DX; Wikswo, JP, IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 53, 1901-1910 , (2006)

Magnetometric corrosion sensing under hydrodynamic conditions. Juzeliunas, E; Ma; YP; Wikswo, JP, JOURNAL OF SOLID STATE ELECTROCHEMISTRY, 10, 700-707 , (2006)

Multianalyte microphysiometry as a tool in metabolomics and systems biology. Eklund, SE; Snider, RM; Wikswo, J; Baudenbacher, F; Prokop, A; Cliffel, DE, JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 587, 333-339 , (2006)

Quantum dot probes for monitoring dynamic cellular response: Reporters of T cell activation. Warnement, MR; Faley, SL; Wikswo, JP; Rosenthal, SJ, IEEE TRANSACTIONS ON NANOBIOSCIENCE, 5, 268-272 , (2006)

The IL sequence in the LLKIL motif in CXCR2 is required for full ligand-induced activation of ErK, Akt, and chemotaxis in HL60 cells. Sai, JQ; Walker, G; Wikswo, J; Richmond, A, JOURNAL OF BIOLOGICAL CHEMISTRY, 281, 35931-35941 , (2006)

Virtual electrode effects around an artifical heterogeneity during field stimulation of cardiac tissue. Woods, MC; Sidorov, VY; Holcomb, MR; Beaudoin, DL; Roth, RJ; Wikswo, JP, HEART RHYTHM, 3, 751-752 , (2006)

Extracting metabolic fluxes from measurements with a multianalyte Microphysiometer. Velkovsky, M; Cliffel, D; Eklund, S; Eluvathingal, S; Stremler, M; Wikswo, J, BIOPHYSICAL JOURNAL, 88, 521A-522A , (2005)

Mobility of protozoa through narrow channels. Wang, W; Shor, LM; LeBoeuf, EJ; Wikswo, JP; Kosson, DS, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 71, 4628-4637 , (2005)

Rapid Stimulations Causes Electrical Remodeling in Cultured Atrial Myocytes. Yang, Z; Shen, W; Rottman, JN; Wikswo, JP; Murray, KT, J MOLE CELL CARDIOL, 38, 299-308 , (2005)

Vector projection of biomagnetic fields. Bradshaw, LA; Myers, A; Richards, WO; Drake, W; Wikswo, JP, MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, 43, 85-93 , (2005)

A microfluidic device to confine a single cardiac myocyte in a sub-nanoliter volume on planar microelectrodes for extracellular potential recordings. Werdich, AA; Lima, EA; Ivanov, B; Ges, I; Anderson, ME; Wikswo, JP; Baudenbacher, FJ, LAB ON A CHIP, 4, 357-362 , (2004)

Heat conduction calorimeter for massively parallel high throughput measurements with picoliter sample volumes. Chancellor, EB; Wikswo, JP; Baudenbacher, F; Radparvar, M; Osterman, D, APPLIED PHYSICS LETTERS, 85, 2408-2410 , (2004)

High resolution magnetic images of planar wave fronts reveal bidomain properties of cradiac tissue. Holzer, JR; Fong, LE; Sidorov, VY; Wikswo, JP; Baudenbacher, F, BIOPHYSICAL JOURNAL, 87, 4326-4332 , (2004)

NanoLiterBioReactor: Long-term mammalian cell culture at nanofabricated scale. Prokop, A; Prokop, Z; Schaffer, D; Kozlov, E; Wikswo, J; Cliffel, D; Baudenbacher, F, BIOMEDICAL MICRODEVICES, 6, 325-339 , (2004)

Remote sensing of aluminum alloy corrosion by SQUID magnetometry. Juzeliunas, E; Ma, YP; Wikswo, JP, JOURNAL OF SOLID STATE ELECTROCHEMISTRY, 8, 435-441 , (2004)

Simultaneous monitoring of the corrosion activity and moisture inside aircraft lap joints. Cooper, KR; Ma, Y; Wikswo, JP; Kelly, RG, CORROSION ENGINEERING SCIENCE AND TECHNOLOGY, 39, 339-345 , (2004)

A spatio-temporal dipole simulation of gastrointestinal magnetic fields. Bradshaw, LA; Myers, A; Wikswo, JP; Richard, WO, IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 50, 836-847 , (2003)

Examination of optical depth effects on fluorescence imaging of cardiac propagation. Bray, MA; Wikswo, JP, BIOPHYSICAL JOURNAL, 85, 4134-4145 , (2003)

Interaction dynamics of a pair of vortex filament rings. Bray, MA; Wikswo, JP, PHYSICAL REVIEW LETTERS, 90, 238303 , (2003)

Modification of the Cytosensor (TM) microphysiometer to simultaneously measure extracellular acidification and oxygen consumption rates. Eklund, SE; Cliffel, DE; Kozlov, E; Prokop, A; Wikswo, J; Baudenbacher, F, ANALYTICA CHIMICA ACTA, 496, 93-101 , (2003)

Spatiotemporal dynamics of damped propagation in excitable cardiac tissue. Sidorov, VY; Aliev, RR; Woods, MC; Baudenbacher, F; Baudenbacher, P; Wikswo, JP, PHYSICAL REVIEW LETTERS, 91, 208104 , (2003)

High resolution low-temperature superconductivity superconducting quantum interference device microscope for imaging magnetic fields of samples at room temperature. Baudenbacher, F; Peters, NT; Wikswo, JP, REVIEW OF SCIENTIFIC INSTRUMENTS, 73, 1247-1254 , (2002)

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