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Piston, David
Louise B. McGavock Chair
Director of Biophotonics Institute
Professor of Molecular Physiology and Biophysics
Professor of Physics
Professor of Chemical and Biomolecular Engineering

Research Information

The diabetes-related research base at Vanderbilt builds on the longstanding, broad-based excellence of basic and clinical research at Vanderbilt and encompasses a wide range of scientific disciplines and specialties related to the physiology of carbohydrate, protein, and fat metabolism, the pathogenesis and treatment of diabetes, the complications of diabetes, and the translation of new knowledge to the clinic and the community. Based on common scientific interests, we group DRTC-affiliated investigators into seven research areas:

  • In Vivo Metabolic Regulation and Obesity
  • Signal transduction and gene regulation
  • Islet Development, Biology, and Immunology
  • Clinical Research
  • Complications of Diabetes
  • Translational Research
  • Oxidative stress


Selected Publications

Fluorescent proteins at a glance. Kremers, GJ; Gilbert, SG; Cranfill, PJ; Davidson, MW; Piston, DW, JOURNAL OF CELL SCIENCE, 124, 157-160 , (2011)

Fluorescence Anisotropy of Protein Complexes in Living Cells. Piston, DW, BIOPHYSICAL JOURNAL, 99, 1685-1686 , (2010)

Glucose Suppression of Glucagon Secretion METABOLIC AND CALCIUM RESPONSES FROM alpha-CELLS IN INTACT MOUSE PANCREATIC ISLETS. Le Marchand, SJ; Piston, DW, JOURNAL OF BIOLOGICAL CHEMISTRY, 285, 14389-14398 , (2010)

Glucose-dependent blood flow dynamics in murine pancreatic islets in vivo. Nyman, LR; Ford, E; Powers, AC; Piston, DW, AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 298, E807-E814 , (2010)

Noninvasive multiphoton fluorescence microscopy resolves retinol and retinal condensation products in mouse eyes. Palczewska, G; Maeda, T; Imanishi, Y; Sun, WY; Chen, Y; Williams, DR; Piston, DW; Maeda, A; Palczewski, K, NATURE MEDICINE, 16, 1444-U130 , (2010)

Rapid Extravasation and Establishment of Breast Cancer Micrometastases in the Liver Microenvironment. Martin, MD; Kremers, GJ; Short, KW; Rocheleau, JV; Xu, L; Piston, DW; Matrisian, LM; Gorden, DL, MOLECULAR CANCER RESEARCH, 8, 1319-1327 , (2010)

Selective Visualization of Cyclooxygenase-2 in Inflammation and Cancer by Targeted Fluorescent Imaging Agents. Uddin, MJ; Crews, BC; Blobaum, AL; Kingsley, PJ; Gorden, DL; McIntyre, JO; Matrisian, LM; Subbaramaiah, K; Dannenberg, AJ; Piston, DW; Marnett, LJ, CANCER RESEARCH, 70, 3618-3627 , (2010)

Breast cancer metastases rapidly extravasate from the vasculature in a murine model of liver metastasis. Martin, MD; Kremers, GJ; Rocheleau, JV; Piston, DW; Matrisian, LM; Gorden, DL, CLINICAL & EXPERIMENTAL METASTASIS, 26, 901-901 , (2009)

Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion. Pound, LD; Sarkar, SA; Benninger, RKP; Wang, YD; Suwanichkul, A; Shadoan, MK; Printz, RL; Oeser, JK; Lee, CE; Piston, DW; McGuinness, OP; Hutton, JC; Powell, DR; O'Brien, RM, BIOCHEMICAL JOURNAL, 421, 371-376 , (2009)

Electron microscopy of whole cells in liquid with nanometer resolution. de Jonge, N; Peckys, DB; Kremers, GJ; Piston, DW, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106, 2159-2164 , (2009)

Flecainide Inhibits Arrhythmogenic Ca2+ Waves by Open State Block of Ryanodine Receptor Ca2+ Release Channels and Reduction of Ca2+ Spark Mass. Hilliard, FA; Laver, D; Le Marchand, SJ; Piston, DW; Knollmann, BG, CIRCULATION, 120, S667-S667 , (2009)

Fluorescence microscopy benefits from advances in single-photon detectors. Benninger, RKP; Piston, DW, LASER FOCUS WORLD, 45, 59-+ , (2009)

Photoconversion in orange and red fluorescent proteins. Kremers, GJ; Hazelwood, KL; Murphy, CS; Davidson, MW; Piston, DW, NATURE METHODS, 6, 355-U55 , (2009)

Rapid and inexpensive fabrication of polymeric microfluidic devices via toner transfer masking. Easley, CJ; Benninger, RKP; Shaver, JH; Head, WS; Piston, DW, LAB ON A CHIP, 9, 1119-1127 , (2009)

Subcutaneous transplantation of embryonic pancreas for correction of type 1 diabetes. Gunawardana, SC; Benninger, RKP; Piston, DW, AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 296, E323-E332 , (2009)

Combining Microfluidics and Quantitative Fluorescence Microscopy to Examine Pancreatic Islet Molecular Physiology. Rocheleau, JV; Piston, DW, BIOPHYSICAL TOOLS FOR BIOLOGISTS, VOL 2: IN VIVO TECHNIQUES, 89, 71-+ , (2008)

Dimethyl amiloride improves glucose homeostasis in mouse models of type 2 diabetes. Gunawardana, SC; Head, WS; Piston, DW, AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 294, E1097-E1108 , (2008)

Establishment and quantitative imaging of a 3D lung organotypic model of mammary tumor outgrowth. Martin, MD; Fingleton, B; Lynch, CC; Wells, S; McIntyre, JO; Piston, DW; Matrisian, LM, CLINICAL & EXPERIMENTAL METASTASIS, 25, 877-885 , (2008)

FRET by fluorescence polarization microscopy. Piston, DW; Rizzo, MA, FLUORESCENT PROTEINS, SECOND EDITION, 85, 415-430 , (2008)

Gap Junction Coupling and Calcium Waves in the Pancreatic Islet. Benninger, RKP; Zhang, M; Head, WS; Satin, LS; Piston, DW, BIOPHYSICAL JOURNAL, 95, 5048-5061 , (2008)

Infrared Scanning Near-Field Optical Microscopy Below the Diffraction Limit. Sanghera, JS; Aggarwal, ID; Cricenti, A; Generosi, R; Luce, M; Perfetti, P; Margaritondo, G; Tolk, NH; Piston, D, IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS, 14, 1343-1352 , (2008)

Infrared scanning near-field optical microscopy investigates order and clusters in model membranes. Generosi, J; Margaritondo, G; Sanghera, JS; Aggarwal, ID; Tolk, NH; Piston, DW; Castellano, AC; Cricenti, A, JOURNAL OF MICROSCOPY-OXFORD, 229, 259-263 , (2008)

Kinetics of a collagen-like polypeptide fragmentation after mid-IR free-electron laser ablation. Zavalin, A; Hachey, DL; Sundaramoorthy, M; Banerjee, S; Morgan, S; Feldman, L; Tolk, N; Piston, DW, BIOPHYSICAL JOURNAL, 95, 1371-1381 , (2008)

Low-frequency electromagnetic field effects on functional groups in human skin keratinocytes cells revealed by IR-SNOM. Cricenti, A; Generosi, R; Luce, M; Perfetti, P; Sanghera, JS; Aggarwa, ID; Tolk, NH; Vobornik, D; Margaritondo, G; Piston, DW; Manni, V; Grimaldi, S; Lisi, A; Rieti, S, JOURNAL OF MICROSCOPY-OXFORD, 229, 551-554 , (2008)

Multi-photon excitation imaging of dynamic processes in living cells and tissues. Benninger, RKP; Hao, M; Piston, DW, REVIEWS OF PHYSIOLOGY, BIOCHEMISTRY AND PHARMACOLOGY, VOL 160, 160, 71-92 , (2008)

Optical lock-in detection of FRET using synthetic and genetically encoded optical switches. Mao, S; Benninger, RKP; Yan, YL; Petchprayoon, C; Jackson, D; Easley, CJ; Piston, DW; Marriott, G, BIOPHYSICAL JOURNAL, 94, 4515-4524 , (2008)

Photobleaching-free infrared near-field microscopy localizes molecules in neurons. Generosi, J; Margaritondo, G; Kropf, M; Hirling, H; Catsicas, S; Johnsson, K; Tolk, NH; Piston, DW; Cricenti, A, JOURNAL OF APPLIED PHYSICS, 104, 106102 , (2008)

Real-time, multidimensional in vivo imaging used to investigate blood flow in mouse pancreatic islets. Nyman, LR; Wells, KS; Head, WS; McCaughey, M; Ford, E; Brissova, M; Piston, DW; Powers, AC, JOURNAL OF CLINICAL INVESTIGATION, 118, 3790-3797 , (2008)

Single-photon-counting detector for increased sensitivity in two-photon laser scanning microscopy. Benninger, RKP; Ashby, WJ; Ring, EA; Piston, DW, OPTICS LETTERS, 33, 2895-2897 , (2008)

Turning fluorescent proteins into energy-saving light bulbs. Kremers, GJ; Piston, DW, NATURE METHODS, 5, 472-473 , (2008)

Direct effect of cholesterol on insulin secretion - A novel mechanism for pancreatic beta-cell dysfunction. Hao, M; Head, WS; Gunawardana, SC; Hasty, AH; Piston, DW, DIABETES, 56, 2328-2338 , (2007)

Fluorescent protein FRET: the good, the bad and the ugly. Piston, DW; Kremers, GJ, TRENDS IN BIOCHEMICAL SCIENCES, 32, 407-414 , (2007)

Infrared scanning near-field optical microscopy observation of low-frequency electromagnetic field effects on functional groups in eukaryotic cells. Cricenti, A; Generosi, R; Luce, M; Ronci, F; Perfetti, P; Vobornik, D; Margaritondo, G; Sanghera, JS; Aggarwal, ID; Tolk, NH; Piston, DW; Grimaldi, S; Lisi, A; Rieti, S, APPLIED PHYSICS LETTERS, 90, 033902 , (2007)

Insulin response patterns of pancreatic islets to microfluidically-controlled glucose waves. Easley, CJ; Rocheleau, JV; Head, WS; Piston, DW, BIOPHYSICAL JOURNAL, , 650A-650A , (2007)

Leptin requires canonical migratory signaling pathways for induction of monocyte and macrophage chemotaxis. Gruen, ML; Hao, MM; Piston, DW; Hasty, AH, AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 293, C1481-C1488 , (2007)

Metabolic regulation of SIRT1 transcription via a HIC1 : CtBP corepressor complex. Zhang, QH; Wang, SY; Fleuriel, C; Leprince, D; Rocheleau, JV; Piston, DW; Goodman, RH, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 104, 829-833 , (2007)

Methods to study gap junction conductance in pancreatic islets. Benninger, RKP; Le Marchand, SJP; Rocheleau, JV; Head, WS; Zhang, M; Satin, LS; Piston, DW, BIOPHYSICAL JOURNAL, , 443A-443A , (2007)

Naked2 acts as a cargo recognition and targeting protein to ensure proper delivery and fusion of TGF-alpha-containing exocytic vesicles at the lower lateral membrane of polarized MDCK cells. Li, CX; Hao, MM; Cao, Z; Ding, W; Graves-Deal, R; Hu, JY; Piston, DW; Coffey, RJ, MOLECULAR BIOLOGY OF THE CELL, 18, 3081-3093 , (2007)

X-ray structure of cerulean GFP: A tryptophan-based chromophore useful for fluorescence lifetime imaging. Malo, GD; Pouwels, LJ; Wang, MT; Weichsel, A; Montfort, WR; Rizzo, MA; Piston, DW; Wachter, RM, BIOCHEMISTRY, 46, 9865-9873 , (2007)

Nano-Raman mapping of porous glass ceramics with a scanning near-field optical microscope in collection mode. Zavalin, A; Cricenti, A; Generosi, R; Luce, M; Morgan, S; Piston, D, APPLIED PHYSICS LETTERS, 88, 133126 , (2006)

Spectroscopic infrared near-field microscopy and x-ray reflectivity studies of order and clustering in lipid membranes. Generosi, J; Margaritondo, G; Sandhera, JS; Aggarwal, ID; Tolk, NH; Piston, DW; Castellano, AC; Cricenti, A, APPLIED PHYSICS LETTERS, 89, 233906 , (2006)

Spectroscopic infrared scanning near-field optical microscopy (IR-SNOM). Vobornik, D; Margaritondo, G; Sanghera, JS; Thielen, P; Aggarwal, ID; Ivanov, B; Tolk, NH; Manni, V; Grimaldi, S; Lisi, A; Rieti, S; Piston, DW; Generosi, R; Luce, M; Perfetti, P; Cricenti, A, JOURNAL OF ALLOYS AND COMPOUNDS, 401, 80-85 , (2005)

Infrared near-field microscopy with the Vanderbilt free electron laser: overview and perspectives. Vobornik, D; Margaritondo, G; Sanghera, JS; Thielen, P; Aggarwal, ID; Ivanov, B; Miller, JK; Haglund, R; Tolk, NH; Congiu-Castellano, A; Rizzo, MA; Piston, DW; Somma, F; Baldacchini, G; Bonfigli, F; Marolo, T; Flora, F; Montereali, RM; Faenov, A; Pikuz, T; Longo, G; Mussi, V; Generosi, R; Luce, M; Perfetti, P; Cricenti, A, INFRARED PHYSICS & TECHNOLOGY, 45, 409-416 , (2004)

Optical nanospectroscopy applications in material science. Cricenti, A; Longo, G; Ustione, A; Mussi, V; Generosi, R; Luce, M; Rinaldi, M; Perfetti, P; Vobornik, D; Margaritondo, G; Sanghera, JS; Thielen, P; Aggarwal, ID; Ivanov, B; Miller, JK; Haglund, R; Tolk, NH; Congiu-Castellano, A; Rizzo, MA; Piston, DW; Somma, F; Baldacchini, G; Bonfigli, F; Marolo, T; Flora, F; Montereali, RM; Faenov, A; Pikuz, T, APPLIED SURFACE SCIENCE, 234, 374-386 , (2004)

Optical nanospectroscopy study of ion-implanted silicon and biological growth medium. Cricenti, A; Marocchi, V; Generosi, R; Luce, M; Perfetti, P; Vobornik, D; Margaritondo, G; Talley, D; Thielen, P; Sanghera, JS; Aggarwal, ID; Miller, JK; Tolk, NH; Piston, DW, JOURNAL OF ALLOYS AND COMPOUNDS, 362, 21-25 , (2004)

AFM and SNOM characterization of carboxylic acid terminated silicon and silicon nitride surfaces. Cricenti, A; Longo, G; Luce, M; Generosi, R; Perfetti, P; Vobornik, D; Margaritondo, G; Thielen, P; Sanghera, JS; Aggarwal, ID; Miller, JK; Tolk, NH; Piston, DW; Cattaruzza, F; Flamini, A; Prosperi, T; Mezzi, A, SURFACE SCIENCE, 544, 51-57 , (2003)

Chemically resolved imaging of biological cells and thin films by infrared scanning near-field optical microscopy. Cricenti, A; Generosi, R; Luce, M; Perfetti, P; Margaritondo, G; Talley, D; Sanghera, JS; Aggarwal, ID; Tolk, NH; Congiu-Castellano, A; Rizzo, MA; Piston, DW, BIOPHYSICAL JOURNAL, 85, 2705-2710 , (2003)


Phone: 615-322-7030
Email: dave.piston@vanderbilt.edu
Website: Click to Visit

 
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