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Crowe, James E.
Professor of Pediatrics
Professor of Pathology, Microbiology and Immunology
Ingram Professor of Cancer Research
Director, Vanderbilt Vaccine Center

Research Information

Professor J. Crowe studies focus on the molecular basis for the development of effective T and B cell responses to viruses in humans, and on the cell biology of virus infection in polarized epithelial cells. He also has active programs in biodefense research, vaccine and monoclonal antibody development, nanomedicine, and biotechnology. Scientists in the laboratory are developing virus vaccines based on gold nanoparticle technology.

Selected Publications

Ablation of subcellular structures using laser-induced reactive oxygen species. Stone, JW; Crowe, JE, NANOMEDICINE, 6, 15-15 , (2011)

Combination chemotherapy delivered by a targeted nanoparticle. Stone, JW; Crowe, JE, NANOMEDICINE, 6, 16-16 , (2011)

Folate receptor-targeted silica nanoparticles. Stone, JW; Crowe, JE, NANOMEDICINE, 6, 16-16 , (2011)

Human Metapneumovirus Infection as an Emerging Pathogen Causing Acute Respiratory Distress Syndrome Reply. Williams, JV; Crowe, JE, JOURNAL OF INFECTIOUS DISEASES, 203, 296-296 , (2011)

Imaging of cells using integrin-targeted nanoparticles and multiphoton-absorption-induced-luminescence. Stone, JW; Crowe, JE, NANOMEDICINE, 6, 17-17 , (2011)

Increased control of peptide conjugation to nanoparticles using a heterobifunctional linker strategy. Stone, JW; Crowe, JE, NANOMEDICINE, 6, 15-16 , (2011)

Regulatory T cell expression of CLA or alpha(4)beta(7) and skin or gut acute GVHD outcomes. Engelhardt, BG; Jagasia, M; Savani, BN; Bratcher, NL; Greer, JP; Jiang, A; Kassim, AA; Lu, P; Schuening, F; Yoder, SM; Rock, MT; Crowe, JE, BONE MARROW TRANSPLANTATION, 46, 436-442 , (2011)

Severe pandemic 2009 H1N1 influenza disease due to pathogenic immune complexes. Monsalvo, AC; Batalle, JP; Lopez, MF; Krause, JC; Klemenc, J; Hernandez, JZ; Maskin, B; Bugna, J; Rubinstein, C; Aguilar, L; Dalurzo, L; Libster, R; Savy, V; Baumeister, E; Aguilar, L; Cabral, G; Font, J; Solari, L; Weller, KP; Johnson, J; Echavarria, M; Edwards, KM; Chappell, JD; Crowe, JE; Williams, JV; Melendi, GA; Polack, FP, NATURE MEDICINE, 17, 195-U225 , (2011)

Cloning of Quaternary Specific Antibodies. Hicar, MD; Chen, X; Briney, B; Willis, J; Kalams, S; Spearman, P; Crowe, JE, AIDS RESEARCH AND HUMAN RETROVIRUSES, 26, A54-A55 , (2010)

Emerging studies of human HIV-specific antibody repertoires. Hicar, MD; Kalams, SA; Spearman, PW; Crowe, JE, VACCINE, 28, B18-B23 , (2010)

Homing in on Acute Graft vs. Host Disease: Tissue-Specific T Regulatory and Th17 Cells. Engelhardt, BG; Crowe, JE, CHEMOKINE SYSTEM IN EXPERIMENTAL AND CLINICAL HEMATOLOGY, 341, 121-146 , (2010)

Naturally Occurring Human Monoclonal Antibodies Neutralize both 1918 and 2009 Pandemic Influenza A (H1N1) Viruses. Krause, JC; Tumpey, TM; Huffman, CJ; McGraw, PA; Pearce, MB; Tsibane, T; Hai, R; Basler, CF; Crowe, JE, JOURNAL OF VIROLOGY, 84, 3127-3130 , (2010)

Population-Based Incidence of Human Metapneumovirus Infection among Hospitalized Children. Williams, JV; Edwards, KM; Weinberg, GA; Griffin, MR; Hall, CB; Zhu, YW; Szilagyi, PG; Wang, CYK; Yang, CF; Silva, D; Ye, D; Spaete, RR; Crowe, JE, JOURNAL OF INFECTIOUS DISEASES, 201, 1890-1898 , (2010)

Pseudovirion Particles Bearing Native HIV Envelope Trimers Facilitate a Novel Method for Generating Human Neutralizing Monoclonal Antibodies Against HIV. Hicar, MD; Chen, XM; Briney, B; Hammonds, J; Wang, JJ; Kalams, S; Spearman, PW; Crowe, JE, JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 54, 223-235 , (2010)

Respiratory Syncytial Virus Induces Host RNA Stress Granules To Facilitate Viral Replication. Lindquist, ME; Lifland, AW; Utley, TJ; Santangelo, PJ; Crowe, JE, JOURNAL OF VIROLOGY, 84, 12274-12284 , (2010)

Specificity for Human Hemoglobin Enhances Staphylococcus aureus Infection. Pishchany, G; McCoy, AL; Torres, VJ; Krause, JC; Crowe, JE; Fabry, ME; Skaar, EP, CELL HOST & MICROBE, 8, 544-550 , (2010)

Structural Basis of Preexisting Immunity to the 2009 H1N1 Pandemic Influenza Virus. Xu, R; Ekiert, DC; Krause, JC; Hai, R; Crowe, JE; Wilson, IA, SCIENCE, 328, 357-360 , (2010)

Surfing a genetic association interaction network to identify modulators of antibody response to smallpox vaccine. Davis, NA; Crowe, JE; Pajewski, NM; McKinney, BA, GENES AND IMMUNITY, 11, 630-636 , (2010)

Transforming Growth Factor Beta Is a Major Regulator of Human Neonatal Immune Responses following Respiratory Syncytial Virus Infection. Thornburg, NJ; Shepherd, B; Crowe, JE, JOURNAL OF VIROLOGY, 84, 12895-12902 , (2010)

A Chimeric A2 Strain of Respiratory Syncytial Virus (RSV) with the Fusion Protein of RSV Strain Line 19 Exhibits Enhanced Viral Load, Mucus, and Airway Dysfunction. Moore, ML; Chi, MH; Luongo, C; Lukacs, NW; Polosukhin, VV; Huckabee, MM; Newcomb, DC; Buchholz, UJ; Crowe, JE; Goleniewska, K; Williams, JV; Collins, PL; Peebles, RS, JOURNAL OF VIROLOGY, 83, 4185-4194 , (2009)

Amphiregulin-Deficient Mice Develop Spasmolytic Polypeptide Expressing Metaplasia and Intestinal Metaplasia. Nam, KT; Lee, HJ; Mok, H; Romero-Gallo, J; Crowe, JE; Peek, RM; Goldenring, JR, GASTROENTEROLOGY, 136, 1288-1296 , (2009)

Capturing the Spectrum of Interaction Effects in Genetic Association Studies by Simulated Evaporative Cooling Network Analysis. McKinney, BA; Crowe, JE; Guo, JY; Tian, DH, PLOS GENETICS, 5, e1000432 , (2009)

Coronavirus Infection and Hospitalizations for Acute Respiratory Illness in Young Children. Talbot, HKB; Crowe, JE; Edwards, KM; Griffin, MR; Zhu, YW; Weinberg, GA; Szilagyi, PG; Hall, CB; Podsiad, AB; Iwane, M; Williams, JV, JOURNAL OF MEDICAL VIROLOGY, 81, 853-856 , (2009)

Genetic diversity and evolution of human metapneumovirus fusion protein over twenty years. Yang, CF; Wang, CK; Tollefson, SJ; Piyaratna, R; Lintao, LD; Chu, M; Liem, A; Mark, M; Spaete, RR; Crowe, JE; Williams, JV, VIROLOGY JOURNAL, 6, 138 , (2009)

Integrated analysis of genetic and proteomic data identifies biomarkers associated with adverse events following smallpox vaccination. Reif, DM; Motsinger-Reif, AA; McKinney, BA; Rock, MT; Crowe, JE; Moore, JH, GENES AND IMMUNITY, 10, 112-119 , (2009)

Recent advances in the study of human antibody responses to influenza virus using optimized human hybridoma approaches. Crowe, JE, VACCINE, 27, G47-G51 , (2009)

Single molecule-sensitive probes for imaging RNA in live cells. Santangelo, PJ; Lifland, AW; Curt, P; Sasaki, Y; Bassell, GJ; Lindquist, ME; Crowe, JE, NATURE METHODS, 6, 347-U46 , (2009)

The human neonatal B cell response to respiratory syncytial virus uses a biased antibody variable gene repertoire that lacks somatic mutations. Williams, JV; Weitkamp, JH; Blum, DL; LaFleur, BJ; Crowe, JE, MOLECULAR IMMUNOLOGY, 47, 407-414 , (2009)

The Pediatric Burden of Human Coronaviruses Evaluated for Twenty Years. Talbot, HK; Shepherd, BE; Crowe, JE; Griffin, MR; Edwards, KM; Podsiad, AB; Tollefson, SJ; Wright, PF; Williams, JV, PEDIATRIC INFECTIOUS DISEASE JOURNAL, 28, 682-687 , (2009)

A clinical isolate strain of respiratory syncytial virus (RSV) causes airway obstruction and histopathology in mice similar to severe RSV disease in infants. Moore, ML; Chi, MH; Williams, JV; Wright, PF; Crowe, JE; Edwards, KM; Polosukhin, VV; Goleniewska, K; Peebles, RS, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 121, 1036 , (2008)

An Alphavirus Replicon-Based Human Metapneumovirus Vaccine Is Immunogenic and Protective in Mice and Cotton Rats. Mok, H; Tollefson, SJ; Podsiad, AB; Shepherd, BE; Polosukhin, VV; Johnston, RE; Williams, JV; Crowe, JE, JOURNAL OF VIROLOGY, 82, 11410-11418 , (2008)

An optimized electrofusion-based protocol for generating virus-specific human monoclonal antibodies. Yu, XC; McGraw, PA; House, FS; Crowe, JE, JOURNAL OF IMMUNOLOGICAL METHODS, 336, 142-151 , (2008)

Circulating Gut- or Skin-Homing Regulatory T Cells (Tregs) Predict Whether Acute Graft-Versus-Host Disease (aGVHD) Occurs in Gut or Skin Following Allogeneic Stem Cell Transplantation (ASCT). Engelhardt, B; Jagasia, M; Rock, MT; Bratcher, NL; Greer, JP; Jiang, AX; Kassim, AA; Lu, PC; Schuening, F; Crowe, JE, BLOOD, 112, 266-267 , (2008)

Enhancement of the CD8(+) T cell response to a subdominant epitope of respiratory syncytial virus by deletion of an immunodominant epitope. Mok, H; Lee, S; Wright, DW; Crowe, JE, VACCINE, 26, 4775-4782 , (2008)

Functional maturation of the human antibody response to rotavirus. Kallewaard, NL; McKinney, BA; Gu, Y; Chen, A; Prasad, BVV; Crowe, JE, JOURNAL OF IMMUNOLOGY, 180, 3980-3989 , (2008)

Genetic basis for adverse events after smallpox vaccination. Reif, DM; McKinney, BA; Motsinger, AA; Chanock, SJ; Edwards, KM; Rock, MT; Moore, JH; Crowe, JE, JOURNAL OF INFECTIOUS DISEASES, 198, 16-22 , (2008)

Human metapneumovirus nucleoprotein and phosphoprotein interact and provide the minimal requirements for inclusion body formation. Derdowski, A; Peters, TR; Glover, N; Qian, R; Utley, TJ; Burnett, A; Williams, JV; Spearman, P; Crowe, JE, JOURNAL OF GENERAL VIROLOGY, 89, 2698-2708 , (2008)

Immunodominance of the V(H)1-46 antibody gene segment in the primary repertoire of human rotavirus-specific B cells is reduced in the memory compartment through somatic mutation of nondominant clones. Tian, CX; Luskin, GK; Dischert, KM; Higginbotham, JN; Shepherd, BE; Crowe, JE, JOURNAL OF IMMUNOLOGY, 180, 3279-3288 , (2008)

Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors. Yu, XC; Tsibane, T; McGraw, PA; House, FS; Keefer, CJ; Hicar, MD; Tumpey, TM; Pappas, C; Perrone, LA; Martinez, O; Stevens, J; Wilson, IA; Aguilar, PV; Altschuler, EL; Basler, CF; Crowe, JE, NATURE, 455, 532-U41 , (2008)

Respiratory syncytial virus uses a Vps4-independent budding mechanism controlled by Rab11-FIP2. Utley, TJ; Ducharme, NA; Varthakavi, V; Shepherd, BE; Santangelo, PJ; Lindquist, ME; Goldenring, JR; Crowe, JE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105, 10209-10214 , (2008)

A recombinant human monoclonal antibody to human metapneumovirus fusion protein that neutralizes virus in vitro and is effective therapeutically in vivo. Williams, JV; Chen, ZF; Cseke, G; Wright, DW; Keefer, CJ; Tollefson, SJ; Hessell, A; Podsiad, A; Shepherd, BE; Sanna, PP; Burton, DR; Crowe, JE; Williamson, RA, JOURNAL OF VIROLOGY, 81, 8315-8324 , (2007)

Evaporative cooling feature selection for genotypic data involving interactions. McKinney, BA; Reif, DM; White, BC; Crowe, JE; Moore, JH, BIOINFORMATICS, 23, 2113-2120 , (2007)

Evidence for preferential Ig gene usage and differential TdT and exonuclease activities in human naive and memory B cells. Tian, CX; Luskin, GK; Dischert, KM; Higginbotham, JN; Shepherd, BE; Crowe, JE, MOLECULAR IMMUNOLOGY, 44, 2173-2183 , (2007)

Examination of a fusogenic hexameric core from human metapneumovirus and identification of a potent synthetic peptide inhibitor from the heptad repeat 1 region. Miller, SA; Tollefson, S; Crowe, JE; Williams, JV; Wright, DW, JOURNAL OF VIROLOGY, 81, 141-149 , (2007)

Genetic predisposition for adverse events after vaccination. Crowe, JE, JOURNAL OF INFECTIOUS DISEASES, 196, 176-177 , (2007)

Human metapneumovirus fusion protein vaccines that are immunogenic and protective in cotton rats. Cseke, G; Wright, DW; Tollefson, SJ; Johnson, JE; Crowe, JE; Williams, JV, JOURNAL OF VIROLOGY, 81, 698-707 , (2007)

Tissue-specific regulation of CD8(+) T-lymphocyte immunodominance in respiratory syncytial virus infection. Lee, SJ; Miller, SA; Wright, DW; Rock, MT; Crowe, JE, JOURNAL OF VIROLOGY, 81, 2349-2358 , (2007)

Venezuelan equine encephalitis virus replicon particles encoding respiratory syncytial virus surface glycoproteins induce protective mucosal responses in mice and cotton rats. Mok, H; Lee, S; Utley, TJ; Shepherd, BE; Polosukhin, VV; Collier, ML; Davis, NL; Johnston, RE; Crowe, JE, JOURNAL OF VIROLOGY, 81, 13710-13722 , (2007)

Progression of respiratory syncytial virus infection monitored by fluorescent quantum dot probes. Bentzen, EL; House, F; Utley, TJ; Crowe, JE; Wright, DW, NANO LETTERS, 5, 591-595 , (2005)

Phone: 615-343-8064
Email: james.crowe@Vanderbilt.Edu
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Vanderbilt University